DegronMD

Uniprot ID: Q8N1G0

Source protein: Zinc finger protein 687

Source gene: ZNF687

Class: DEG_SCF_FBW7_2

Location: 375:381

E3 ligase: FBXW7

DEGRON score: 0.9614

ASA_SCORE: 96.7429

COIL: 0.9053

CONS_SCORE: 0.456

DSS_SCORE: 0.436

HELIX: 0.0209

FCONS_SCORE: 1.0805

RIG_SCORE: 0.636

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S387N	TCGA-AX-A1CE	UCEC	TCGA	PATPTSE	DEG_SCF_FBW7_2	0.1667
p.S387N	DO42280	UCEC	ICGC	PATPTSE	DEG_SCF_FBW7_2	0.1667
p.V386L	TCGA-CG-5721	STAD	TCGA	PATPTSE	DEG_SCF_FBW7_2	0.1944
p.V386L	DO38192	STAD	ICGC	PATPTSE	DEG_SCF_FBW7_2	0.1944
p.Q389H	TCGA-EO-A22U	UCEC	TCGA	PATPTSE	DEG_SCF_FBW7_2	0.1111
p.Q389H	DO43755	UCEC	ICGC	PATPTSE	DEG_SCF_FBW7_2	0.1111
p.E381K	DO230529	LUSC	ICGC	PATPTSE	DEG_SCF_FBW7_2	0.7022
p.E381K	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	PATPTSE	DEG_SCF_FBW7_2	0.7022
p.E381K	ACH-000951	Lung Cancer	CCLE	PATPTSE	DEG_SCF_FBW7_2	0.7022
p.E381K	NCI-H2342	lung	COSMIC	PATPTSE	DEG_SCF_FBW7_2	0.7022
p.A376V	DO232761	PBCA	ICGC	PATPTSE	DEG_SCF_FBW7_2	0.5825
p.A368T	SIDM00216	Colorectal Carcinoma	GDSC	PATPTSE	DEG_SCF_FBW7_2	0.1389
p.A368T	ACH-000989	Colon/Colorectal Cancer	CCLE	PATPTSE	DEG_SCF_FBW7_2	0.1389
p.P383A	SIDM00191	Kidney Carcinoma	GDSC	PATPTSE	DEG_SCF_FBW7_2	0.2778
p.P383A	ACH-002090	Kidney Cancer	CCLE	PATPTSE	DEG_SCF_FBW7_2	0.2778
p.P383A	BB65-RCC	kidney	COSMIC	PATPTSE	DEG_SCF_FBW7_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N1G0	Zinc finger protein 687	DEG_SCF_FBW7_2	375:381	PATPTSE	FBXW7	0.9614	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons