DegronMD

Uniprot ID: Q8N1G0

Source protein: Zinc finger protein 687

Source gene: ZNF687

Class: DEG_SPOP_SBC_1

Location: 639:643

E3 ligase: SPOP

DEGRON score: 0.9699

ASA_SCORE: 73.82

COIL: 0.774

CONS_SCORE: 0.3591

DSS_SCORE: 0.3011

HELIX: 0.1082

FCONS_SCORE: 0.8215

RIG_SCORE: 0.7318

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P631S	TCGA-BH-A18G	BRCA	TCGA	AITSS	DEG_SPOP_SBC_1	0.1111
p.P631S	TCGA-RW-A8AZ	PCPG	TCGA	AITSS	DEG_SPOP_SBC_1	0.1111
p.P631S	DO3686	BRCA	ICGC	AITSS	DEG_SPOP_SBC_1	0.1111
p.S643Y	DO222874	COCA	ICGC	AITSS	DEG_SPOP_SBC_1	0.712
p.A629S	DO229015	LICA	ICGC	AITSS	DEG_SPOP_SBC_1	0.0556
p.A650T	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	AITSS	DEG_SPOP_SBC_1	0.1389
p.T641P	ACH-001331	Head and Neck Cancer	CCLE	AITSS	DEG_SPOP_SBC_1	0.7031

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8CG34	Nuclear envelope pore membrane protein POM 121C	DEG_SPOP_SBC_1	389:393	AITSS	SPOP	0.9987	More...
Q5RL73	RNA-binding protein 48	DEG_SPOP_SBC_1	264:268	AITSS	SPOP	0.6026	More...
Q8N1G0	Zinc finger protein 687	DEG_SPOP_SBC_1	639:643	AITSS	SPOP	0.9699	More...
Q96HA1	Nuclear envelope pore membrane protein POM 121	DEG_SPOP_SBC_1	412:416	AITSS	SPOP	0.9984	More...
Q9Y2F5	Little elongation complex subunit 1	DEG_SPOP_SBC_1	236:240	AITSS	SPOP	0.9901	More...
Q6ZVF9	G protein-regulated inducer of neurite outgrowth 3	DEG_SPOP_SBC_1	145:149	AITSS	SPOP	0.9606	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons