DegronMD

Uniprot ID: A8CG34

Source protein: Nuclear envelope pore membrane protein POM 121C

Source gene: POM121C

Class: DEG_SPOP_SBC_1

Location: 389:393

E3 ligase: SPOP

DEGRON score: 0.9987

ASA_SCORE: 70.94

COIL: 0.834

CONS_SCORE: 0.8653

DSS_SCORE: 0.5109

HELIX: 0.0296

FCONS_SCORE: 1.0951

RIG_SCORE: 0.6963

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P403A	TCGA-44-8117	LUAD	TCGA	AITSS	DEG_SPOP_SBC_1	0.0556
p.L383I	TCGA-BR-8591	STAD	TCGA	AITSS	DEG_SPOP_SBC_1	0.1667
p.A402V	TCGA-F4-6856	COAD	TCGA	AITSS	DEG_SPOP_SBC_1	0.0833
p.S387F	TCGA-FR-A8YC	SKCM	TCGA	AITSS	DEG_SPOP_SBC_1	0.2778
p.S393F	DO37871	SKCM	ICGC	AITSS	DEG_SPOP_SBC_1	0.9093
p.I382T	DO42673	UCEC	ICGC	AITSS	DEG_SPOP_SBC_1	0.1389
p.R387C	ACH-000634	Brain Cancer	CCLE	AITSS	DEG_SPOP_SBC_1	0.2778
p.S385F	ACH-002236	Lymphoma	CCLE	AITSS	DEG_SPOP_SBC_1	0.6667
p.S385F	EB-3	haematopoietic_and_lymphoid_tissue	COSMIC	AITSS	DEG_SPOP_SBC_1	0.6667
p.P401H	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	AITSS	DEG_SPOP_SBC_1	0.5556
p.T397A	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	AITSS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8CG34	Nuclear envelope pore membrane protein POM 121C	DEG_SPOP_SBC_1	389:393	AITSS	SPOP	0.9987	More...
Q5RL73	RNA-binding protein 48	DEG_SPOP_SBC_1	264:268	AITSS	SPOP	0.6026	More...
Q8N1G0	Zinc finger protein 687	DEG_SPOP_SBC_1	639:643	AITSS	SPOP	0.9699	More...
Q96HA1	Nuclear envelope pore membrane protein POM 121	DEG_SPOP_SBC_1	412:416	AITSS	SPOP	0.9984	More...
Q9Y2F5	Little elongation complex subunit 1	DEG_SPOP_SBC_1	236:240	AITSS	SPOP	0.9901	More...
Q6ZVF9	G protein-regulated inducer of neurite outgrowth 3	DEG_SPOP_SBC_1	145:149	AITSS	SPOP	0.9606	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons