DegronMD

Uniprot ID: Q9Y2F5

Source protein: Little elongation complex subunit 1

Source gene: ICE1

Class: DEG_SPOP_SBC_1

Location: 236:240

E3 ligase: SPOP

DEGRON score: 0.9901

ASA_SCORE: 77.64

COIL: 0.8688

CONS_SCORE: 0.2812

DSS_SCORE: 0.6065

HELIX: 0.0332

FCONS_SCORE: 0.8905

RIG_SCORE: 0.6744

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I237T	GP5d	large_intestine	COSMIC	AITSS	DEG_SPOP_SBC_1	0.5966

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8CG34	Nuclear envelope pore membrane protein POM 121C	DEG_SPOP_SBC_1	389:393	AITSS	SPOP	0.9987	More...
Q5RL73	RNA-binding protein 48	DEG_SPOP_SBC_1	264:268	AITSS	SPOP	0.6026	More...
Q8N1G0	Zinc finger protein 687	DEG_SPOP_SBC_1	639:643	AITSS	SPOP	0.9699	More...
Q96HA1	Nuclear envelope pore membrane protein POM 121	DEG_SPOP_SBC_1	412:416	AITSS	SPOP	0.9984	More...
Q9Y2F5	Little elongation complex subunit 1	DEG_SPOP_SBC_1	236:240	AITSS	SPOP	0.9901	More...
Q6ZVF9	G protein-regulated inducer of neurite outgrowth 3	DEG_SPOP_SBC_1	145:149	AITSS	SPOP	0.9606	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons