DegronMD

Uniprot ID: Q6ZVF9

Source protein: G protein-regulated inducer of neurite outgrowth 3

Source gene: GPRIN3

Class: DEG_SPOP_SBC_1

Location: 145:149

E3 ligase: SPOP

DEGRON score: 0.9606

ASA_SCORE: 78.2

COIL: 0.8888

CONS_SCORE: 0.4656

DSS_SCORE: 0.7566

HELIX: 0.0334

FCONS_SCORE: 0.9597

RIG_SCORE: 0.6353

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S158L	TCGA-78-7150	LUAD	TCGA	AITSS	DEG_SPOP_SBC_1	0.0833
p.S158L	DO24411	LUAD	ICGC	AITSS	DEG_SPOP_SBC_1	0.0833
p.S137F	TCGA-AX-A1CE	UCEC	TCGA	AITSS	DEG_SPOP_SBC_1	0.1111
p.S137F	DO42280	UCEC	ICGC	AITSS	DEG_SPOP_SBC_1	0.1111
p.S154F	TCGA-D3-A5GU	SKCM	TCGA	AITSS	DEG_SPOP_SBC_1	0.1944
p.S154F	TCGA-IB-7651	PAAD	TCGA	AITSS	DEG_SPOP_SBC_1	0.1944
p.S154F	DO46657	PAAD	ICGC	AITSS	DEG_SPOP_SBC_1	0.1944
p.S154F	DO47584	SKCM	ICGC	AITSS	DEG_SPOP_SBC_1	0.1944
p.D153H	TCGA-FD-A43P	BLCA	TCGA	AITSS	DEG_SPOP_SBC_1	0.2222
p.D153H	DO44049	BLCA	ICGC	AITSS	DEG_SPOP_SBC_1	0.2222
p.M156I	TCGA-G2-A2EC	BLCA	TCGA	AITSS	DEG_SPOP_SBC_1	0.1389
p.M156I	DO651	BLCA	ICGC	AITSS	DEG_SPOP_SBC_1	0.1389
p.Q159H	DO48431	BLCA	ICGC	AITSS	DEG_SPOP_SBC_1	0.0556
p.N144D	DO230323	COCA	ICGC	AITSS	DEG_SPOP_SBC_1	0.3056
p.I146V	SIDM01559	Melanoma	GDSC	AITSS	DEG_SPOP_SBC_1	0.5965
p.I146V	ACH-000274	Skin Cancer	CCLE	AITSS	DEG_SPOP_SBC_1	0.5965

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8CG34	Nuclear envelope pore membrane protein POM 121C	DEG_SPOP_SBC_1	389:393	AITSS	SPOP	0.9987	More...
Q5RL73	RNA-binding protein 48	DEG_SPOP_SBC_1	264:268	AITSS	SPOP	0.6026	More...
Q8N1G0	Zinc finger protein 687	DEG_SPOP_SBC_1	639:643	AITSS	SPOP	0.9699	More...
Q96HA1	Nuclear envelope pore membrane protein POM 121	DEG_SPOP_SBC_1	412:416	AITSS	SPOP	0.9984	More...
Q9Y2F5	Little elongation complex subunit 1	DEG_SPOP_SBC_1	236:240	AITSS	SPOP	0.9901	More...
Q6ZVF9	G protein-regulated inducer of neurite outgrowth 3	DEG_SPOP_SBC_1	145:149	AITSS	SPOP	0.9606	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons