DegronMD - A8CG34(POM121C)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G727C	TCGA-28-5211	GBM	TCGA	APSSS	DEG_SPOP_SBC_1	731:735	Mutation rewiring degron network	0.2222
p.P403A	TCGA-44-8117	LUAD	TCGA	AITSS	DEG_SPOP_SBC_1	389:393	Mutation rewiring degron network	0.0556
p.L383I	TCGA-BR-8591	STAD	TCGA	AITSS	DEG_SPOP_SBC_1	389:393	Mutation rewiring degron network	0.1667
p.T882A	TCGA-CD-A48C	STAD	TCGA	PTTTT	DEG_SPOP_SBC_1	868:872	Mutation rewiring degron network	0.0556
p.T882A	TCGA-CD-A48C	STAD	TCGA	ATSSS	DEG_SPOP_SBC_1	887:891	Mutation rewiring degron network	0.1944
p.S872R	TCGA-CD-A4MG	STAD	TCGA	PTTTT	DEG_SPOP_SBC_1	868:872	Mutation altering degron motif	0.7427
p.A783T	TCGA-CM-6171	COAD	TCGA	APTTT	DEG_SPOP_SBC_1	777:781	Mutation rewiring degron network	0.2778
p.A783T	SIDM01113	Other Sarcomas	GDSC	APTTT	DEG_SPOP_SBC_1	777:781	Mutation rewiring degron network	0.2778
p.T836M	TCGA-CM-6674	COAD	TCGA	VSTTT	DEG_SPOP_SBC_1	825:829	Mutation rewiring degron network	0.1389
p.T814I	TCGA-CM-6674	COAD	TCGA	VSSSS	DEG_SPOP_SBC_1	820:824	Mutation rewiring degron network	0.1667
p.T771M	TCGA-CM-6674	COAD	TCGA	APTTT	DEG_SPOP_SBC_1	777:781	Mutation rewiring degron network	0.1667
p.T771M	TCGA-EO-A3AZ	UCEC	TCGA	APTTT	DEG_SPOP_SBC_1	777:781	Mutation rewiring degron network	0.1667
p.P880T	TCGA-CV-7091	HNSC	TCGA	PTTTT	DEG_SPOP_SBC_1	868:872	Mutation rewiring degron network	0.1111
p.P880T	TCGA-CV-7091	HNSC	TCGA	ATSSS	DEG_SPOP_SBC_1	887:891	Mutation rewiring degron network	0.1389
p.T862I	TCGA-EE-A20H	SKCM	TCGA	PTTTT	DEG_SPOP_SBC_1	868:872	Mutation rewiring degron network	0.1667
p.P448L	TCGA-EE-A2MS	SKCM	TCGA	AADTTPRK	DEG_SCF_SKP2-CKS1_1	458:465	Mutation rewiring degron network	0.0556
p.G894S	TCGA-EY-A1GU	UCEC	TCGA	ATSSS	DEG_SPOP_SBC_1	887:891	Mutation rewiring degron network	0.25
p.A402V	TCGA-F4-6856	COAD	TCGA	AITSS	DEG_SPOP_SBC_1	389:393	Mutation rewiring degron network	0.0833
p.S387F	TCGA-FR-A8YC	SKCM	TCGA	AITSS	DEG_SPOP_SBC_1	389:393	Mutation rewiring degron network	0.2778
p.F901L	TCGA-G4-6302	COAD	TCGA	ATSSS	DEG_SPOP_SBC_1	887:891	Mutation rewiring degron network	0.0556
p.F901L	TCGA-G4-6302	COAD	TCGA	PATSS	DEG_SPOP_SBC_1	907:911	Mutation rewiring degron network	0.1667
p.P724L	TCGA-GN-A266	SKCM	TCGA	APSSS	DEG_SPOP_SBC_1	731:735	Mutation rewiring degron network	0.1389
p.I752N	TCGA-HF-A5NB	STAD	TCGA	PTTTS	DEG_SPOP_SBC_1	738:742	Mutation rewiring degron network	0.0556
p.T904P	DO48400	BLCA	ICGC	PATSS	DEG_SPOP_SBC_1	907:911	Mutation rewiring degron network	0.25
p.A906T	DO7828	COAD	ICGC	PATSS	DEG_SPOP_SBC_1	907:911	Mutation rewiring degron network	0.3056
p.F1141C	DO7801	COAD	ICGC	VGSTT	DEG_SPOP_SBC_1	1145:1149	Mutation rewiring degron network	0.2222
p.F1143L	DO8778	COAD	ICGC	VGSTT	DEG_SPOP_SBC_1	1145:1149	Mutation rewiring degron network	0.2778
p.S453F	DO222450	ESCA	ICGC	AADTTPRK	DEG_SCF_SKP2-CKS1_1	458:465	Mutation blocking phosphorylation signal	0.6389
p.G1092W	DO51551	KIRP	ICGC	VATPGSS	DEG_SCF_FBW7_1	1095:1101	Mutation rewiring degron network	0.25
p.I858V	DO228941	LICA	ICGC	PTTTT	DEG_SPOP_SBC_1	868:872	Mutation rewiring degron network	0.0556
p.S1090R	DO229026	LICA	ICGC	VATPGSS	DEG_SCF_FBW7_1	1095:1101	Mutation rewiring degron network	0.1944
p.T728S	DO224615	LUSC	ICGC	APSSS	DEG_SPOP_SBC_1	731:735	Mutation rewiring degron network	0.25
p.T728S	DO224615	LUSC	ICGC	PTTTS	DEG_SPOP_SBC_1	738:742	Mutation rewiring degron network	0.0556
p.S536L	DO231075	LUSC	ICGC	VTETPPTT	DEG_SCF_FBW7_1	539:546	Mutation rewiring degron network	0.25
p.A556T	DO220876	MELA	ICGC	VTETPPTT	DEG_SCF_FBW7_1	539:546	Mutation rewiring degron network	0.0556
p.S393F	DO37871	SKCM	ICGC	AITSS	DEG_SPOP_SBC_1	389:393	Mutation altering degron motif	0.9093
p.T1104I	DO37986	SKCM	ICGC	VATPGSS	DEG_SCF_FBW7_1	1095:1101	Mutation rewiring degron network	0.25
p.P907R	DO229227	THCA	ICGC	PATSS	DEG_SPOP_SBC_1	907:911	Mutation altering degron motif	0.7512
p.G1146V	DO229250	THCA	ICGC	VGSTT	DEG_SPOP_SBC_1	1145:1149	Mutation altering degron motif	0.6421
p.D894N	DO41572	UCEC	ICGC	ATSSS	DEG_SPOP_SBC_1	887:891	Mutation rewiring degron network	0.25
p.P555S	DO41542	UCEC	ICGC	VTETPPTT	DEG_SCF_FBW7_1	539:546	Mutation rewiring degron network	0.0833
p.A448V	DO41235	UCEC	ICGC	AADTTPRK	DEG_SCF_SKP2-CKS1_1	458:465	Mutation rewiring degron network	0.0556
p.G1136S	DO41518	UCEC	ICGC	VGSTT	DEG_SPOP_SBC_1	1145:1149	Mutation rewiring degron network	0.0833
p.I382T	DO42673	UCEC	ICGC	AITSS	DEG_SPOP_SBC_1	389:393	Mutation rewiring degron network	0.1389
p.A534D	DO42673	UCEC	ICGC	VTETPPTT	DEG_SCF_FBW7_1	539:546	Mutation rewiring degron network	0.1944
p.P834S	SIDM02026	Colorectal Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	820:824	Mutation rewiring degron network	0.0556
p.P834S	SIDM02026	Colorectal Carcinoma	GDSC	VSTTT	DEG_SPOP_SBC_1	825:829	Mutation rewiring degron network	0.1944
p.A739P	SIDM00074	Burkitt's Lymphoma	GDSC	PTTTS	DEG_SPOP_SBC_1	738:742	Mutation altering degron motif	0.7503
p.A739P	BL-70	haematopoietic and lymphoid tissue	COSMIC	PTTTS	DEG_SPOP_SBC_1	738:742	Mutation altering degron motif	0.7503
p.K472T	SIDM01126	Small Cell Lung Carcinoma	GDSC	AADTTPRK	DEG_SCF_SKP2-CKS1_1	458:465	Mutation rewiring degron network	0.1389
p.K472T	SIDM00694	Other Solid Cancers	GDSC	AADTTPRK	DEG_SCF_SKP2-CKS1_1	458:465	Mutation rewiring degron network	0.1389
p.K472T	SIDM00954	Breast Carcinoma	GDSC	AADTTPRK	DEG_SCF_SKP2-CKS1_1	458:465	Mutation rewiring degron network	0.1389
p.K472T	HUTU-80	small intestine	COSMIC	AADTTPRK	DEG_SCF_SKP2-CKS1_1	458:465	Mutation rewiring degron network	0.1389
p.T918N	SIDM00496	Thyroid Gland Carcinoma	GDSC	PATSS	DEG_SPOP_SBC_1	907:911	Mutation rewiring degron network	0.1389
p.T918N	SIDM00296	Small Cell Lung Carcinoma	GDSC	PATSS	DEG_SPOP_SBC_1	907:911	Mutation rewiring degron network	0.1389
p.T918N	SIDM00040	Gastric Carcinoma	GDSC	PATSS	DEG_SPOP_SBC_1	907:911	Mutation rewiring degron network	0.1389
p.T918N	HTC-C3	thyroid	COSMIC	PATSS	DEG_SPOP_SBC_1	907:911	Mutation rewiring degron network	0.1389
p.T918N	LU-134-A	lung	COSMIC	PATSS	DEG_SPOP_SBC_1	907:911	Mutation rewiring degron network	0.1389
p.T918N	TMK-1	stomach	COSMIC	PATSS	DEG_SPOP_SBC_1	907:911	Mutation rewiring degron network	0.1389
p.T918N	HCC-56	large intestine	COSMIC	PATSS	DEG_SPOP_SBC_1	907:911	Mutation rewiring degron network	0.1389
p.G884R	SIDM00230	Small Cell Lung Carcinoma	GDSC	ATSSS	DEG_SPOP_SBC_1	887:891	Mutation rewiring degron network	0.25
p.G884R	IST-SL2	lung	COSMIC	ATSSS	DEG_SPOP_SBC_1	887:891	Mutation rewiring degron network	0.25
p.F767V	SIDM00194	Colorectal Carcinoma	GDSC	APTTT	DEG_SPOP_SBC_1	777:781	Mutation rewiring degron network	0.0556
p.G769S	SIDM00151	Ovarian Carcinoma	GDSC	APTTT	DEG_SPOP_SBC_1	777:781	Mutation substituting flanking lysine	0.2222
p.G891C	SIDM00739	Non-Small Cell Lung Carcinoma	GDSC	ATSSS	DEG_SPOP_SBC_1	887:891	Mutation altering degron motif	0.76
p.G891C	NCI-H1734	lung	COSMIC	ATSSS	DEG_SPOP_SBC_1	887:891	Mutation altering degron motif	0.76
p.S874G	SIDM01045	Endometrial Carcinoma	GDSC	PTTTT	DEG_SPOP_SBC_1	868:872	Mutation rewiring degron network	0.2778
p.S874G	EN	endometrium	COSMIC	PTTTT	DEG_SPOP_SBC_1	868:872	Mutation rewiring degron network	0.2778
p.H772Q	SIDM00208	Glioblastoma	GDSC	APTTT	DEG_SPOP_SBC_1	777:781	Mutation rewiring degron network	0.1944
p.H772Q	D-502MG	central nervous system	COSMIC	APTTT	DEG_SPOP_SBC_1	777:781	Mutation rewiring degron network	0.1944
p.S790L	SIDM00740	Squamous Cell Lung Carcinoma	GDSC	APTTT	DEG_SPOP_SBC_1	777:781	Mutation rewiring degron network	0.0833
p.S790L	NCI-H1703	lung	COSMIC	APTTT	DEG_SPOP_SBC_1	777:781	Mutation rewiring degron network	0.0833
p.A917T	SIDM00217	Colorectal Carcinoma	GDSC	PATSS	DEG_SPOP_SBC_1	907:911	Mutation rewiring degron network	0.1667
p.A917T	ACH-000999	Colon/Colorectal Cancer	CCLE	PATSS	DEG_SPOP_SBC_1	907:911	Mutation rewiring degron network	0.1667
p.A917T	SNU-1040	large intestine	COSMIC	PATSS	DEG_SPOP_SBC_1	907:911	Mutation rewiring degron network	0.1667
p.A786T	SIDM00289	B-Lymphoblastic Leukemia	GDSC	APTTT	DEG_SPOP_SBC_1	777:781	Mutation rewiring degron network	0.1944
p.A786T	HAL-01	haematopoietic and lymphoid tissue	COSMIC	APTTT	DEG_SPOP_SBC_1	777:781	Mutation rewiring degron network	0.1944
p.P748L	SIDM00531	Pancreatic Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	738:742	Mutation rewiring degron network	0.1667
p.P748L	ACH-000213	Pancreatic Cancer	CCLE	PTTTS	DEG_SPOP_SBC_1	738:742	Mutation rewiring degron network	0.1667
p.P748L	HuP-T4	pancreas	COSMIC	PTTTS	DEG_SPOP_SBC_1	738:742	Mutation rewiring degron network	0.1667
p.G810S	SIDM01685	B-Lymphoblastic Leukemia	GDSC	VSSSS	DEG_SPOP_SBC_1	820:824	Mutation substituting flanking lysine	0.1667
p.T831A	SIDM01424	B-Lymphoblastic Leukemia	GDSC	VSSSS	DEG_SPOP_SBC_1	820:824	Mutation rewiring degron network	0.1389
p.T831A	SIDM01424	B-Lymphoblastic Leukemia	GDSC	VSTTT	DEG_SPOP_SBC_1	825:829	Mutation rewiring degron network	0.2778
p.A906S	ACH-000059	Leukemia	CCLE	PATSS	DEG_SPOP_SBC_1	907:911	Mutation rewiring degron network	0.3056
p.E541G	ACH-000141	Gallbladder Cancer	CCLE	VTETPPTT	DEG_SCF_FBW7_1	539:546	Mutation altering degron motif	0.6087
p.P811A	ACH-000217	Liver Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	820:824	Mutation rewiring degron network	0.0833
p.P811A	ACH-000543	Brain Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	820:824	Mutation rewiring degron network	0.0833
p.P746L	ACH-000224	Non-Cancerous	CCLE	PTTTS	DEG_SPOP_SBC_1	738:742	Mutation rewiring degron network	0.2222
p.P722L	ACH-000253	Colon/Colorectal Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	731:735	Mutation rewiring degron network	0.0833
p.P1085L	ACH-000331	Lung Cancer	CCLE	VATPGSS	DEG_SCF_FBW7_1	1095:1101	Mutation rewiring degron network	0.0556
p.D894G	ACH-000475	Liver Cancer	CCLE	ATSSS	DEG_SPOP_SBC_1	887:891	Mutation rewiring degron network	0.25
p.D530E	ACH-000494	Non-Cancerous	CCLE	VTETPPTT	DEG_SCF_FBW7_1	539:546	Mutation rewiring degron network	0.0833
p.Q770E	ACH-000515	Lung Cancer	CCLE	APTTT	DEG_SPOP_SBC_1	777:781	Mutation rewiring degron network	0.1389
p.Q770E	ACH-000612	Lymphoma	CCLE	APTTT	DEG_SPOP_SBC_1	777:781	Mutation rewiring degron network	0.1389
p.R387C	ACH-000634	Brain Cancer	CCLE	AITSS	DEG_SPOP_SBC_1	389:393	Mutation rewiring degron network	0.2778
p.E1150Q	ACH-000685	Pancreatic Cancer	CCLE	VGSTT	DEG_SPOP_SBC_1	1145:1149	Mutation rewiring degron network	0.3056
p.T916M	ACH-000835	Sarcoma	CCLE	PATSS	DEG_SPOP_SBC_1	907:911	Mutation rewiring degron network	0.1944
p.L915V	ACH-000835	Sarcoma	CCLE	PATSS	DEG_SPOP_SBC_1	907:911	Mutation rewiring degron network	0.2222
p.P778S	ACH-000943	Colon/Colorectal Cancer	CCLE	APTTT	DEG_SPOP_SBC_1	777:781	Mutation altering degron motif	0.5641
p.P750S	ACH-000961	Endometrial/Uterine Cancer	CCLE	PTTTS	DEG_SPOP_SBC_1	738:742	Mutation rewiring degron network	0.1111
p.S1108G	ACH-000988	Endometrial/Uterine Cancer	CCLE	VATPGSS	DEG_SCF_FBW7_1	1095:1101	Mutation rewiring degron network	0.1389
p.S1108G	MFE-319	endometrium	COSMIC	VATPGSS	DEG_SCF_FBW7_1	1095:1101	Mutation rewiring degron network	0.1389
p.S385F	ACH-002236	Lymphoma	CCLE	AITSS	DEG_SPOP_SBC_1	389:393	Mutation blocking phosphorylation signal	0.6667
p.S385F	EB-3	haematopoietic and lymphoid tissue	COSMIC	AITSS	DEG_SPOP_SBC_1	389:393	Mutation blocking phosphorylation signal	0.6667
p.P738Q	ACH-002287	Colon/Colorectal Cancer	CCLE	PTTTS	DEG_SPOP_SBC_1	738:742	Mutation altering degron motif	0.7035
p.P738Q	NCI-H630	large intestine	COSMIC	PTTTS	DEG_SPOP_SBC_1	738:742	Mutation altering degron motif	0.7035
p.A864V	ES8	bone	COSMIC	PTTTT	DEG_SPOP_SBC_1	868:872	Mutation rewiring degron network	0.2222
p.A1106V	ES8	bone	COSMIC	VATPGSS	DEG_SCF_FBW7_1	1095:1101	Mutation rewiring degron network	0.1944
p.S866G	MFE-319	endometrium	COSMIC	PTTTT	DEG_SPOP_SBC_1	868:872	Mutation rewiring degron network	0.2778
p.P401H	GR-ST	haematopoietic and lymphoid tissue	COSMIC	AITSS	DEG_SPOP_SBC_1	389:393	Mutation blocking phosphorylation signal	0.5556
p.A1159T	SNU-1040	large intestine	COSMIC	VGSTT	DEG_SPOP_SBC_1	1145:1149	Mutation rewiring degron network	0.0556
p.S823T	RPMI-8226	haematopoietic and lymphoid tissue	COSMIC	VSSSS	DEG_SPOP_SBC_1	820:824	Mutation altering degron motif	0.6005
p.P470S	COLO-792	skin	COSMIC	AADTTPRK	DEG_SCF_SKP2-CKS1_1	458:465	Mutation rewiring degron network	0.1944
p.T397A	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	AITSS	DEG_SPOP_SBC_1	389:393	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

POM121C

UniProt ID: A8CG34

Entrez ID:

Protein name: Nuclear envelope pore membrane protein POM 121C (Nuclear pore membrane protein 121-2) (POM121-2) (Pore membrane protein of 121 kDa C)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for POM121C in