DegronMD

Uniprot ID: A8CG34

Source protein: Nuclear envelope pore membrane protein POM 121C

Source gene: POM121C

Class: DEG_SPOP_SBC_1

Location: 738:742

E3 ligase: SPOP

DEGRON score: 0.9721

ASA_SCORE: 85.6

COIL: 0.95

CONS_SCORE: 0.6193

DSS_SCORE: 0.6174

HELIX: 0.018

FCONS_SCORE: 1.0158

RIG_SCORE: 0.6126

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I752N	TCGA-HF-A5NB	STAD	TCGA	PTTTS	DEG_SPOP_SBC_1	0.0556
p.T728S	DO224615	LUSC	ICGC	PTTTS	DEG_SPOP_SBC_1	0.0556
p.A739P	SIDM00074	Burkitt's Lymphoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7503
p.A739P	BL-70	haematopoietic_and_lymphoid_tissue	COSMIC	PTTTS	DEG_SPOP_SBC_1	0.7503
p.P748L	SIDM00531	Pancreatic Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.1667
p.P748L	ACH-000213	Pancreatic Cancer	CCLE	PTTTS	DEG_SPOP_SBC_1	0.1667
p.P748L	HuP-T4	pancreas	COSMIC	PTTTS	DEG_SPOP_SBC_1	0.1667
p.P746L	ACH-000224	Non-Cancerous	CCLE	PTTTS	DEG_SPOP_SBC_1	0.2222
p.P750S	ACH-000961	Endometrial/Uterine Cancer	CCLE	PTTTS	DEG_SPOP_SBC_1	0.1111
p.P738Q	ACH-002287	Colon/Colorectal Cancer	CCLE	PTTTS	DEG_SPOP_SBC_1	0.7035
p.P738Q	NCI-H630	large_intestine	COSMIC	PTTTS	DEG_SPOP_SBC_1	0.7035

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A1A4S6	Rho GTPase-activating protein 10	DEG_SPOP_SBC_1	693:697	PTTTS	SPOP	0.9308	More...
A8CG34	Nuclear envelope pore membrane protein POM 121C	DEG_SPOP_SBC_1	738:742	PTTTS	SPOP	0.9721	More...
P34810	Macrosialin	DEG_SPOP_SBC_1	81:85	PTTTS	SPOP	0.9583	More...
Q6ZSS7	Major facilitator superfamily domain-containing protein 6	DEG_SPOP_SBC_1	424:428	PTTTS	SPOP	0.5073	More...
Q96D42	Hepatitis A virus cellular receptor 1	DEG_SPOP_SBC_1	197:201	PTTTS	SPOP	0.9976	More...
Q96HA1	Nuclear envelope pore membrane protein POM 121	DEG_SPOP_SBC_1	761:765	PTTTS	SPOP	0.9806	More...
Q9H987	Synaptopodin 2-like protein	DEG_SPOP_SBC_1	480:484	PTTTS	SPOP	0.9703	More...
Q9NZP6	Nuclear pore-associated protein 1	DEG_SPOP_SBC_1	883:887	PTTTS	SPOP	0.9896	More...
Q9UBP5	Hairy/enhancer-of-split related with YRPW motif protein 2	DEG_SPOP_SBC_1	40:44	PTTTS	SPOP	0.8075	More...
Q9Y4F4	TOG array regulator of axonemal microtubules protein 1	DEG_SPOP_SBC_1	61:65	PTTTS	SPOP	0.9973	More...
Q9Y618	Nuclear receptor corepressor 2	DEG_SPOP_SBC_1	1788:1792	PTTTS	SPOP	0.9962	More...
Q5T0B9	Zinc finger protein 362	DEG_SPOP_SBC_1	148:152	PTTTS	SPOP	0.9988	More...
A6NF01	Putative nuclear envelope pore membrane protein POM 121B	DEG_SPOP_SBC_1	345:349	PTTTS	SPOP	0.9532	More...
Q5T0Z8	Uncharacterized protein C6orf132	DEG_SPOP_SBC_1	699:703	PTTTS	SPOP	0.9973	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons