DegronMD

Uniprot ID: Q9Y618

Source protein: Nuclear receptor corepressor 2

Source gene: NCOR2

Class: DEG_SPOP_SBC_1

Location: 1788:1792

E3 ligase: SPOP

DEGRON score: 0.9962

ASA_SCORE: 99.8

COIL: 0.971

CONS_SCORE: 0.3615

DSS_SCORE: 0.8299

HELIX: 0.0198

FCONS_SCORE: 1.1195

RIG_SCORE: 0.5673

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1792F	TCGA-CC-A3MA	LIHC	TCGA	PTTTS	DEG_SPOP_SBC_1	0.7982
p.Y1791H	SNU-C5	large_intestine	COSMIC	PTTTS	DEG_SPOP_SBC_1	0.7229
p.S1794F	TCGA-EE-A182	SKCM	TCGA	PTTTS	DEG_SPOP_SBC_1	0.7222
p.S1794F	TCGA-FW-A3TU	SKCM	TCGA	PTTTS	DEG_SPOP_SBC_1	0.7222
p.R1794W	KMS-11	haematopoietic_and_lymphoid_tissue	COSMIC	PTTTS	DEG_SPOP_SBC_1	0.7222
p.R1794W	GOTO	autonomic_ganglia	COSMIC	PTTTS	DEG_SPOP_SBC_1	0.7222
p.R1783Q	CAL-39	vulva	COSMIC	PTTTS	DEG_SPOP_SBC_1	0.6389
p.K1787Q	TCGA-19-5956	GBM	TCGA	PTTTS	DEG_SPOP_SBC_1	0.3056
p.L1785F	TCGA-75-5126	LUAD	TCGA	PTTTS	DEG_SPOP_SBC_1	0.25
p.E1785K	DO222868	MELA	ICGC	PTTTS	DEG_SPOP_SBC_1	0.25
p.R1796L	DO47665	SKCM	ICGC	PTTTS	DEG_SPOP_SBC_1	0.2222
p.R1796W	DO41584	UCEC	ICGC	PTTTS	DEG_SPOP_SBC_1	0.2222
p.D1797E	DO52671	MALY	ICGC	PTTTS	DEG_SPOP_SBC_1	0.1944
p.R1798W	DO44615	LGG	ICGC	PTTTS	DEG_SPOP_SBC_1	0.1667
p.S1782F	DO23058	LIHC	ICGC	PTTTS	DEG_SPOP_SBC_1	0.1667
p.E1799D	DO2020	BRCA	ICGC	PTTTS	DEG_SPOP_SBC_1	0.1389
p.R1800Q	CAL-39	vulva	COSMIC	PTTTS	DEG_SPOP_SBC_1	0.1111
p.S1800I	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	PTTTS	DEG_SPOP_SBC_1	0.1111

Showing 1 to 18 of 18 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UBP5	Hairy/enhancer-of-split related with YRPW motif protein 2	DEG_SPOP_SBC_1	40:44	PTTTS	SPOP	0.8075	More...
Q96D42	Hepatitis A virus cellular receptor 1	DEG_SPOP_SBC_1	197:201	PTTTS	SPOP	0.9976	More...
P34810	Macrosialin	DEG_SPOP_SBC_1	81:85	PTTTS	SPOP	0.9583	More...
Q6ZSS7	Major facilitator superfamily domain-containing protein 6	DEG_SPOP_SBC_1	424:428	PTTTS	SPOP	0.5073	More...
Q96HA1	Nuclear envelope pore membrane protein POM 121	DEG_SPOP_SBC_1	761:765	PTTTS	SPOP	0.9806	More...
A8CG34	Nuclear envelope pore membrane protein POM 121C	DEG_SPOP_SBC_1	738:742	PTTTS	SPOP	0.9721	More...
Q9NZP6	Nuclear pore-associated protein 1	DEG_SPOP_SBC_1	883:887	PTTTS	SPOP	0.9896	More...
Q9Y618	Nuclear receptor corepressor 2	DEG_SPOP_SBC_1	1788:1792	PTTTS	SPOP	0.9962	More...
A6NF01	Putative nuclear envelope pore membrane protein POM 121B	DEG_SPOP_SBC_1	345:349	PTTTS	SPOP	0.9532	More...
A1A4S6	Rho GTPase-activating protein 10	DEG_SPOP_SBC_1	693:697	PTTTS	SPOP	0.9308	More...
Q9H987	Synaptopodin 2-like protein	DEG_SPOP_SBC_1	480:484	PTTTS	SPOP	0.9703	More...
Q9Y4F4	TOG array regulator of axonemal microtubules protein 1	DEG_SPOP_SBC_1	61:65	PTTTS	SPOP	0.9973	More...
Q5T0Z8	Uncharacterized protein C6orf132	DEG_SPOP_SBC_1	699:703	PTTTS	SPOP	0.9973	More...
Q5T0B9	Zinc finger protein 362	DEG_SPOP_SBC_1	148:152	PTTTS	SPOP	0.9988	More...

Showing 1 to 14 of 14 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons