DegronMD - Q9UBP5(HEY2)

GO - Biological processes (BP): anterior/posterior axis specification [GO:0009948]; anterior/posterior pattern specification [GO:0009952]; aortic valve morphogenesis [GO:0003180]; arterial endothelial cell differentiation [GO:0060842]; ascending aorta morphogenesis [GO:0035910]; atrial septum morphogenesis [GO:0060413]; cardiac conduction system development [GO:0003161]; cardiac epithelial to mesenchymal transition [GO:0060317]; cardiac left ventricle morphogenesis [GO:0003214]; cardiac muscle hypertrophy in response to stress [GO:0014898]; cardiac right ventricle morphogenesis [GO:0003215]; cardiac septum morphogenesis [GO:0060411]; cardiac vascular smooth muscle cell development [GO:0060948]; cardiac ventricle morphogenesis [GO:0003208]; cell fate commitment [GO:0045165]; circulatory system development [GO:0072359]; cochlea development [GO:0090102]; coronary vasculature morphogenesis [GO:0060977]; dorsal aorta morphogenesis [GO:0035912]; endocardial cushion to mesenchymal transition involved in heart valve formation [GO:0003199]; epithelial to mesenchymal transition involved in endocardial cushion formation [GO:0003198]; heart trabecula formation [GO:0060347]; labyrinthine layer blood vessel development [GO:0060716]; mesenchymal cell development [GO:0014031]; muscular septum morphogenesis [GO:0003150]; negative regulation of biomineral tissue development [GO:0070168]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of cardiac vascular smooth muscle cell differentiation [GO:2000723]; negative regulation of gene expression [GO:0010629]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription by transcription factor localization [GO:0010621]; negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation [GO:2000820]; negative regulation of transcription initiation from RNA polymerase II promoter [GO:0060633]; negative regulation of transcription regulatory region DNA binding [GO:2000678]; Notch signaling involved in heart development [GO:0061314]; Notch signaling pathway [GO:0007219]; outflow tract morphogenesis [GO:0003151]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of gene expression [GO:0010628]; positive regulation of heart rate [GO:0010460]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein-DNA complex assembly [GO:0065004]; pulmonary artery morphogenesis [GO:0061156]; pulmonary valve morphogenesis [GO:0003184]; regulation of inner ear auditory receptor cell differentiation [GO:0045607]; regulation of neurogenesis [GO:0050767]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of vasculogenesis [GO:2001212]; smooth muscle cell differentiation [GO:0051145]; tricuspid valve formation [GO:0003195]; tricuspid valve morphogenesis [GO:0003186]; umbilical cord morphogenesis [GO:0036304]; vascular associated smooth muscle cell development [GO:0097084]; vasculogenesis [GO:0001570]; ventricular cardiac muscle cell development [GO:0055015]; ventricular septum morphogenesis [GO:0060412]; ventricular trabecula myocardium morphogenesis [GO:0003222] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A247T	TCGA-49-4490	LUAD	TCGA	PLSTS	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.1944
p.A247T	DO11483	GBM	ICGC	PLSTS	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.1944
p.A266D	TCGA-55-8204	LUAD	TCGA	PLSTS	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.0556
p.S33Y	TCGA-AX-A2HC	UCEC	TCGA	PTTTS	DEG_SPOP_SBC_1	40:44	Mutation rewiring degron network	0.1389
p.A48V	TCGA-FI-A2D5	UCEC	TCGA	PTTTS	DEG_SPOP_SBC_1	40:44	Mutation rewiring degron network	0.2222
p.R52M	TCGA-FI-A2D5	UCEC	TCGA	PTTTS	DEG_SPOP_SBC_1	40:44	Mutation rewiring degron network	0.1111
p.S245N	TCGA-VQ-A8P2	STAD	TCGA	PLSTS	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.1389
p.A253T	DO230312	COCA	ICGC	PLSTS	DEG_SPOP_SBC_1	252:256	Mutation altering degron motif	0.7139
p.A253T	DO220902	MELA	ICGC	PLSTS	DEG_SPOP_SBC_1	252:256	Mutation altering degron motif	0.7139
p.I257S	DO14353	HNSC	ICGC	PLSTS	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.3056
p.A39P	DO25360	LUAD	ICGC	PTTTS	DEG_SPOP_SBC_1	40:44	Mutation blocking phosphorylation signal	0.75
p.A252P	DO24682	LUAD	ICGC	PLSTS	DEG_SPOP_SBC_1	252:256	Mutation altering degron motif	0.7503
p.A253P	DO24682	LUAD	ICGC	PLSTS	DEG_SPOP_SBC_1	252:256	Mutation altering degron motif	0.7503
p.A253V	DO37146	READ	ICGC	PLSTS	DEG_SPOP_SBC_1	252:256	Mutation altering degron motif	0.6936
p.V263A	DO42023	UCEC	ICGC	PLSTS	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.1389
p.A247E	DO43698	UCEC	ICGC	PLSTS	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.1944
p.L243F	DO42673	UCEC	ICGC	PLSTS	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.0833
p.S30I	SIDM01126	Small Cell Lung Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	40:44	Mutation rewiring degron network	0.0556
p.S30I	ACH-001599	Lung Cancer	CCLE	PTTTS	DEG_SPOP_SBC_1	40:44	Mutation rewiring degron network	0.0556
p.S30I	NCI-H64	lung	COSMIC	PTTTS	DEG_SPOP_SBC_1	40:44	Mutation rewiring degron network	0.0556
p.R52K	SIDM00728	Non-Small Cell Lung Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	40:44	Mutation rewiring degron network	0.1111
p.R52K	NCI-H2291	lung	COSMIC	PTTTS	DEG_SPOP_SBC_1	40:44	Mutation rewiring degron network	0.1111
p.S256F	SIDM00630	Breast Carcinoma	GDSC	PLSTS	DEG_SPOP_SBC_1	252:256	Mutation altering degron motif	0.7982
p.S256F	ACH-000876	Breast Cancer	CCLE	PLSTS	DEG_SPOP_SBC_1	252:256	Mutation altering degron motif	0.7982
p.S256F	MDA-MB-415	breast	COSMIC	PLSTS	DEG_SPOP_SBC_1	252:256	Mutation altering degron motif	0.7982
p.T43S	SIDM00520	Mesothelioma	GDSC	PTTTS	DEG_SPOP_SBC_1	40:44	Mutation altering degron motif	0.6005
p.V246I	SIDM01664	Prostate Carcinoma	GDSC	PLSTS	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.1667
p.V246I	ACH-000952	Prostate Cancer	CCLE	PLSTS	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.1667
p.A252G	SNU-81	large intestine	COSMIC	PLSTS	DEG_SPOP_SBC_1	252:256	Mutation altering degron motif	0.754

Kaplan plot for HEY2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HEY2

UniProt ID: Q9UBP5

Entrez ID: 23493

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HEY2 in