DegronMD

Uniprot ID: Q9UBP5

Source protein: Hairy/enhancer-of-split related with YRPW motif protein 2

Source gene: HEY2

Class: DEG_SPOP_SBC_1

Location: 40:44

E3 ligase: SPOP

DEGRON score: 0.8075

ASA_SCORE: 94.46

COIL: 0.7554

CONS_SCORE: 0.3242

DSS_SCORE: 0.6024

HELIX: 0.2474

FCONS_SCORE: 0.6596

RIG_SCORE: 0.7252

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S33Y	TCGA-AX-A2HC	UCEC	TCGA	PTTTS	DEG_SPOP_SBC_1	0.1389
p.A48V	TCGA-FI-A2D5	UCEC	TCGA	PTTTS	DEG_SPOP_SBC_1	0.2222
p.R52M	TCGA-FI-A2D5	UCEC	TCGA	PTTTS	DEG_SPOP_SBC_1	0.1111
p.A39P	DO25360	LUAD	ICGC	PTTTS	DEG_SPOP_SBC_1	0.75
p.S30I	SIDM01126	Small Cell Lung Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.0556
p.S30I	ACH-001599	Lung Cancer	CCLE	PTTTS	DEG_SPOP_SBC_1	0.0556
p.S30I	NCI-H64	lung	COSMIC	PTTTS	DEG_SPOP_SBC_1	0.0556
p.R52K	SIDM00728	Non-Small Cell Lung Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.1111
p.R52K	NCI-H2291	lung	COSMIC	PTTTS	DEG_SPOP_SBC_1	0.1111
p.T43S	SIDM00520	Mesothelioma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.6005

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A1A4S6	Rho GTPase-activating protein 10	DEG_SPOP_SBC_1	693:697	PTTTS	SPOP	0.9308	More...
A8CG34	Nuclear envelope pore membrane protein POM 121C	DEG_SPOP_SBC_1	738:742	PTTTS	SPOP	0.9721	More...
P34810	Macrosialin	DEG_SPOP_SBC_1	81:85	PTTTS	SPOP	0.9583	More...
Q6ZSS7	Major facilitator superfamily domain-containing protein 6	DEG_SPOP_SBC_1	424:428	PTTTS	SPOP	0.5073	More...
Q96D42	Hepatitis A virus cellular receptor 1	DEG_SPOP_SBC_1	197:201	PTTTS	SPOP	0.9976	More...
Q96HA1	Nuclear envelope pore membrane protein POM 121	DEG_SPOP_SBC_1	761:765	PTTTS	SPOP	0.9806	More...
Q9H987	Synaptopodin 2-like protein	DEG_SPOP_SBC_1	480:484	PTTTS	SPOP	0.9703	More...
Q9NZP6	Nuclear pore-associated protein 1	DEG_SPOP_SBC_1	883:887	PTTTS	SPOP	0.9896	More...
Q9UBP5	Hairy/enhancer-of-split related with YRPW motif protein 2	DEG_SPOP_SBC_1	40:44	PTTTS	SPOP	0.8075	More...
Q9Y4F4	TOG array regulator of axonemal microtubules protein 1	DEG_SPOP_SBC_1	61:65	PTTTS	SPOP	0.9973	More...
Q9Y618	Nuclear receptor corepressor 2	DEG_SPOP_SBC_1	1788:1792	PTTTS	SPOP	0.9962	More...
Q5T0B9	Zinc finger protein 362	DEG_SPOP_SBC_1	148:152	PTTTS	SPOP	0.9988	More...
A6NF01	Putative nuclear envelope pore membrane protein POM 121B	DEG_SPOP_SBC_1	345:349	PTTTS	SPOP	0.9532	More...
Q5T0Z8	Uncharacterized protein C6orf132	DEG_SPOP_SBC_1	699:703	PTTTS	SPOP	0.9973	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons