DegronMD - Q5T0B9(ZNF362)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S160P	TCGA-5M-AAT6	COAD	TCGA	PSTPTTT	DEG_SCF_FBW7_1	145:151	Mutation blocking phosphorylation signal	0.5278
p.S160P	TCGA-5M-AAT6	COAD	TCGA	PTTTS	DEG_SPOP_SBC_1	148:152	Mutation blocking phosphorylation signal	0.5556
p.S160P	DO223703	COAD	ICGC	PSTPTTT	DEG_SCF_FBW7_1	145:151	Mutation blocking phosphorylation signal	0.5278
p.S160P	DO223703	COAD	ICGC	PTTTS	DEG_SPOP_SBC_1	148:152	Mutation blocking phosphorylation signal	0.5556
p.G135C	TCGA-B5-A1MU	UCEC	TCGA	PSTPTTT	DEG_SCF_FBW7_1	145:151	Mutation rewiring degron network	0.0556
p.G135C	DO41512	UCEC	ICGC	PSTPTTT	DEG_SCF_FBW7_1	145:151	Mutation rewiring degron network	0.0556
p.T151S	TCGA-BR-8078	STAD	TCGA	PSTPTTT	DEG_SCF_FBW7_1	145:151	Mutation altering degron motif	0.6005
p.T151S	TCGA-BR-8078	STAD	TCGA	PTTTS	DEG_SPOP_SBC_1	148:152	Mutation altering degron motif	0.6005
p.T151S	DO38288	STAD	ICGC	PSTPTTT	DEG_SCF_FBW7_1	145:151	Mutation altering degron motif	0.6005
p.T151S	DO38288	STAD	ICGC	PTTTS	DEG_SPOP_SBC_1	148:152	Mutation altering degron motif	0.6005
p.A158T	TCGA-CR-7382	HNSC	TCGA	PSTPTTT	DEG_SCF_FBW7_1	145:151	Mutation rewiring degron network	0.1389
p.A158T	TCGA-CR-7382	HNSC	TCGA	PTTTS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.1667
p.A158T	DO14171	HNSC	ICGC	PSTPTTT	DEG_SCF_FBW7_1	145:151	Mutation rewiring degron network	0.1389
p.A158T	DO14171	HNSC	ICGC	PTTTS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.1667
p.T124I	TCGA-CS-5397	LGG	TCGA	PATST	DEG_SPOP_SBC_1	110:114	Mutation rewiring degron network	0.0556
p.T124I	DO22336	LGG	ICGC	PATST	DEG_SPOP_SBC_1	110:114	Mutation rewiring degron network	0.0556
p.T138M	TCGA-D1-A174	UCEC	TCGA	PSTPTTT	DEG_SCF_FBW7_1	145:151	Mutation rewiring degron network	0.1389
p.T138M	TCGA-D1-A174	UCEC	TCGA	PTTTS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.0556
p.T138M	DO40900	UCEC	ICGC	PSTPTTT	DEG_SCF_FBW7_1	145:151	Mutation rewiring degron network	0.1389
p.T138M	DO40900	UCEC	ICGC	PTTTS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.0556
p.T138M	SIDM01051	Ovarian Carcinoma	GDSC	PSTPTTT	DEG_SCF_FBW7_1	145:151	Mutation rewiring degron network	0.1389
p.T138M	SIDM01051	Ovarian Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.0556
p.T138M	ACH-000936	Ovarian Cancer	CCLE	PSTPTTT	DEG_SCF_FBW7_1	145:151	Mutation rewiring degron network	0.1389
p.T138M	ACH-000936	Ovarian Cancer	CCLE	PTTTS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.0556
p.T138M	EFO-27	ovary	COSMIC	PSTPTTT	DEG_SCF_FBW7_1	145:151	Mutation rewiring degron network	0.1389
p.T138M	EFO-27	ovary	COSMIC	PTTTS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.0556
p.T140M	TCGA-DI-A2QU	UCEC	TCGA	PSTPTTT	DEG_SCF_FBW7_1	145:151	Mutation rewiring degron network	0.1944
p.T140M	TCGA-DI-A2QU	UCEC	TCGA	PTTTS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.1111
p.T140M	DO233634	GACA	ICGC	PSTPTTT	DEG_SCF_FBW7_1	145:151	Mutation rewiring degron network	0.1944
p.T140M	DO233634	GACA	ICGC	PTTTS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.1111
p.T140M	DO42616	UCEC	ICGC	PSTPTTT	DEG_SCF_FBW7_1	145:151	Mutation rewiring degron network	0.1944
p.T140M	DO42616	UCEC	ICGC	PTTTS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.1111
p.A136T	DO222973	BTCA	ICGC	PSTPTTT	DEG_SCF_FBW7_1	145:151	Mutation rewiring degron network	0.0833
p.A136T	SIDM01099	Neuroblastoma	GDSC	PSTPTTT	DEG_SCF_FBW7_1	145:151	Mutation rewiring degron network	0.0833
p.A136T	SIDM00879	Breast Carcinoma	GDSC	PSTPTTT	DEG_SCF_FBW7_1	145:151	Mutation rewiring degron network	0.0833
p.A136T	SIDM01147	Gastric Carcinoma	GDSC	PSTPTTT	DEG_SCF_FBW7_1	145:151	Mutation rewiring degron network	0.0833
p.A136T	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	PSTPTTT	DEG_SCF_FBW7_1	145:151	Mutation rewiring degron network	0.0833
p.V115I	DO234230	ESAD	ICGC	PATST	DEG_SPOP_SBC_1	110:114	Mutation rewiring degron network	0.3056
p.R109W	DO233941	GACA	ICGC	PATST	DEG_SPOP_SBC_1	110:114	Mutation rewiring degron network	0.3056
p.D103H	DO45299	LIRI	ICGC	PATST	DEG_SPOP_SBC_1	110:114	Mutation rewiring degron network	0.1389
p.G139V	SIDM00962	Chronic Myelogenous Leukemia	GDSC	PSTPTTT	DEG_SCF_FBW7_1	145:151	Mutation rewiring degron network	0.1667
p.G139V	SIDM00962	Chronic Myelogenous Leukemia	GDSC	PTTTS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.0833
p.G139V	ACH-000432	Leukemia	CCLE	PSTPTTT	DEG_SCF_FBW7_1	145:151	Mutation rewiring degron network	0.1667
p.G139V	ACH-000432	Leukemia	CCLE	PTTTS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.0833
p.G139V	BV-173	haematopoietic and lymphoid tissue	COSMIC	PSTPTTT	DEG_SCF_FBW7_1	145:151	Mutation rewiring degron network	0.1667
p.G139V	BV-173	haematopoietic and lymphoid tissue	COSMIC	PTTTS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.0833
p.T138A	SIDM00889	Cervical Carcinoma	GDSC	PSTPTTT	DEG_SCF_FBW7_1	145:151	Mutation rewiring degron network	0.1389
p.T138A	SIDM00889	Cervical Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.0556
p.T138A	ACH-001333	Cervical Cancer	CCLE	PSTPTTT	DEG_SCF_FBW7_1	145:151	Mutation rewiring degron network	0.1389
p.T138A	ACH-001333	Cervical Cancer	CCLE	PTTTS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.0556
p.T138A	C-33-A	cervix	COSMIC	PSTPTTT	DEG_SCF_FBW7_1	145:151	Mutation rewiring degron network	0.1389
p.T138A	C-33-A	cervix	COSMIC	PTTTS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.0556
p.T162P	ACH-001379	Pancreatic Cancer	CCLE	PTTTS	DEG_SPOP_SBC_1	148:152	Mutation blocking phosphorylation signal	0.5

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF362

UniProt ID: Q5T0B9

Entrez ID: 149076

Protein name: Zinc finger protein 362

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF362 in