DegronMD

Uniprot ID: Q5T0B9

Source protein: Zinc finger protein 362

Source gene: ZNF362

Class: DEG_SPOP_SBC_1

Location: 148:152

E3 ligase: SPOP

DEGRON score: 0.9988

ASA_SCORE: 67.52

COIL: 0.8412

CONS_SCORE: 0.5057

DSS_SCORE: 0.6727

HELIX: 0.0424

FCONS_SCORE: 1.1125

RIG_SCORE: 0.681

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S160P	TCGA-5M-AAT6	COAD	TCGA	PTTTS	DEG_SPOP_SBC_1	0.5556
p.S160P	DO223703	COAD	ICGC	PTTTS	DEG_SPOP_SBC_1	0.5556
p.T151S	TCGA-BR-8078	STAD	TCGA	PTTTS	DEG_SPOP_SBC_1	0.6005
p.T151S	DO38288	STAD	ICGC	PTTTS	DEG_SPOP_SBC_1	0.6005
p.A158T	TCGA-CR-7382	HNSC	TCGA	PTTTS	DEG_SPOP_SBC_1	0.1667
p.A158T	DO14171	HNSC	ICGC	PTTTS	DEG_SPOP_SBC_1	0.1667
p.T138M	TCGA-D1-A174	UCEC	TCGA	PTTTS	DEG_SPOP_SBC_1	0.0556
p.T138M	DO40900	UCEC	ICGC	PTTTS	DEG_SPOP_SBC_1	0.0556
p.T138M	SIDM01051	Ovarian Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.0556
p.T138M	ACH-000936	Ovarian Cancer	CCLE	PTTTS	DEG_SPOP_SBC_1	0.0556
p.T138M	EFO-27	ovary	COSMIC	PTTTS	DEG_SPOP_SBC_1	0.0556
p.T140M	TCGA-DI-A2QU	UCEC	TCGA	PTTTS	DEG_SPOP_SBC_1	0.1111
p.T140M	DO233634	GACA	ICGC	PTTTS	DEG_SPOP_SBC_1	0.1111
p.T140M	DO42616	UCEC	ICGC	PTTTS	DEG_SPOP_SBC_1	0.1111
p.G139V	SIDM00962	Chronic Myelogenous Leukemia	GDSC	PTTTS	DEG_SPOP_SBC_1	0.0833
p.G139V	ACH-000432	Leukemia	CCLE	PTTTS	DEG_SPOP_SBC_1	0.0833
p.G139V	BV-173	haematopoietic_and_lymphoid_tissue	COSMIC	PTTTS	DEG_SPOP_SBC_1	0.0833
p.T138A	SIDM00889	Cervical Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.0556
p.T138A	ACH-001333	Cervical Cancer	CCLE	PTTTS	DEG_SPOP_SBC_1	0.0556
p.T138A	C-33-A	cervix	COSMIC	PTTTS	DEG_SPOP_SBC_1	0.0556
p.T162P	ACH-001379	Pancreatic Cancer	CCLE	PTTTS	DEG_SPOP_SBC_1	0.5

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A1A4S6	Rho GTPase-activating protein 10	DEG_SPOP_SBC_1	693:697	PTTTS	SPOP	0.9308	More...
A8CG34	Nuclear envelope pore membrane protein POM 121C	DEG_SPOP_SBC_1	738:742	PTTTS	SPOP	0.9721	More...
P34810	Macrosialin	DEG_SPOP_SBC_1	81:85	PTTTS	SPOP	0.9583	More...
Q6ZSS7	Major facilitator superfamily domain-containing protein 6	DEG_SPOP_SBC_1	424:428	PTTTS	SPOP	0.5073	More...
Q96D42	Hepatitis A virus cellular receptor 1	DEG_SPOP_SBC_1	197:201	PTTTS	SPOP	0.9976	More...
Q96HA1	Nuclear envelope pore membrane protein POM 121	DEG_SPOP_SBC_1	761:765	PTTTS	SPOP	0.9806	More...
Q9H987	Synaptopodin 2-like protein	DEG_SPOP_SBC_1	480:484	PTTTS	SPOP	0.9703	More...
Q9NZP6	Nuclear pore-associated protein 1	DEG_SPOP_SBC_1	883:887	PTTTS	SPOP	0.9896	More...
Q9UBP5	Hairy/enhancer-of-split related with YRPW motif protein 2	DEG_SPOP_SBC_1	40:44	PTTTS	SPOP	0.8075	More...
Q9Y4F4	TOG array regulator of axonemal microtubules protein 1	DEG_SPOP_SBC_1	61:65	PTTTS	SPOP	0.9973	More...
Q9Y618	Nuclear receptor corepressor 2	DEG_SPOP_SBC_1	1788:1792	PTTTS	SPOP	0.9962	More...
Q5T0B9	Zinc finger protein 362	DEG_SPOP_SBC_1	148:152	PTTTS	SPOP	0.9988	More...
A6NF01	Putative nuclear envelope pore membrane protein POM 121B	DEG_SPOP_SBC_1	345:349	PTTTS	SPOP	0.9532	More...
Q5T0Z8	Uncharacterized protein C6orf132	DEG_SPOP_SBC_1	699:703	PTTTS	SPOP	0.9973	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons