DegronMD

Uniprot ID: P34810

Source protein: Macrosialin

Source gene: CD68

Class: DEG_SPOP_SBC_1

Location: 81:85

E3 ligase: SPOP

DEGRON score: 0.9583

ASA_SCORE: 90.36

COIL: 0.9234

CONS_SCORE: 0.6417

DSS_SCORE: 0.7407

HELIX: 0.018

FCONS_SCORE: 1.6716

RIG_SCORE: 0.6168

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T75M	TCGA-AP-A059	UCEC	TCGA	PTTTS	DEG_SPOP_SBC_1	0.1667
p.T75M	SIDM00784	Glioma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.1667
p.T84S	TCGA-F1-6874	STAD	TCGA	PTTTS	DEG_SPOP_SBC_1	0.6005
p.T76I	SIDM00215	Colorectal Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.1944
p.T76I	SIDM00305	Ovarian Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.1944
p.T76I	SIDM00487	Colorectal Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.1944
p.T76I	SIDM00612	Glioma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.1944
p.T76I	SIDM01575	Plasma Cell Myeloma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.1944
p.T83I	SIDM00232	Kidney Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7078
p.T83I	ACH-002168	Kidney Cancer	CCLE	PTTTS	DEG_SPOP_SBC_1	0.7078
p.Q75L	KYSE-220	oesophagus	COSMIC	PTTTS	DEG_SPOP_SBC_1	0.1667
p.T93A	MFE-319	endometrium	COSMIC	PTTTS	DEG_SPOP_SBC_1	0.1111
p.G76E	U-266	haematopoietic_and_lymphoid_tissue	COSMIC	PTTTS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A1A4S6	Rho GTPase-activating protein 10	DEG_SPOP_SBC_1	693:697	PTTTS	SPOP	0.9308	More...
A8CG34	Nuclear envelope pore membrane protein POM 121C	DEG_SPOP_SBC_1	738:742	PTTTS	SPOP	0.9721	More...
P34810	Macrosialin	DEG_SPOP_SBC_1	81:85	PTTTS	SPOP	0.9583	More...
Q6ZSS7	Major facilitator superfamily domain-containing protein 6	DEG_SPOP_SBC_1	424:428	PTTTS	SPOP	0.5073	More...
Q96D42	Hepatitis A virus cellular receptor 1	DEG_SPOP_SBC_1	197:201	PTTTS	SPOP	0.9976	More...
Q96HA1	Nuclear envelope pore membrane protein POM 121	DEG_SPOP_SBC_1	761:765	PTTTS	SPOP	0.9806	More...
Q9H987	Synaptopodin 2-like protein	DEG_SPOP_SBC_1	480:484	PTTTS	SPOP	0.9703	More...
Q9NZP6	Nuclear pore-associated protein 1	DEG_SPOP_SBC_1	883:887	PTTTS	SPOP	0.9896	More...
Q9UBP5	Hairy/enhancer-of-split related with YRPW motif protein 2	DEG_SPOP_SBC_1	40:44	PTTTS	SPOP	0.8075	More...
Q9Y4F4	TOG array regulator of axonemal microtubules protein 1	DEG_SPOP_SBC_1	61:65	PTTTS	SPOP	0.9973	More...
Q9Y618	Nuclear receptor corepressor 2	DEG_SPOP_SBC_1	1788:1792	PTTTS	SPOP	0.9962	More...
Q5T0B9	Zinc finger protein 362	DEG_SPOP_SBC_1	148:152	PTTTS	SPOP	0.9988	More...
A6NF01	Putative nuclear envelope pore membrane protein POM 121B	DEG_SPOP_SBC_1	345:349	PTTTS	SPOP	0.9532	More...
Q5T0Z8	Uncharacterized protein C6orf132	DEG_SPOP_SBC_1	699:703	PTTTS	SPOP	0.9973	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons