DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PTTTS
Uniprot ID:
P34810
Source protein:
Macrosialin
Source gene:
CD68
Class:
DEG_SPOP_SBC_1
Location:
81:85
E3 ligase:
SPOP
DEGRON score:
0.9583
ASA_SCORE:
90.36
COIL:
0.9234
CONS_SCORE:
0.6417
DSS_SCORE:
0.7407
HELIX:
0.018
FCONS_SCORE:
1.6716
RIG_SCORE:
0.6168
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.T83I
SIDM00232
Kidney Carcinoma
GDSC
PTTTS
DEG_SPOP_SBC_1
0.7078
p.T83I
ACH-002168
Kidney Cancer
CCLE
PTTTS
DEG_SPOP_SBC_1
0.7078
p.T84S
TCGA-F1-6874
STAD
TCGA
PTTTS
DEG_SPOP_SBC_1
0.6005
p.T76I
SIDM00215
Colorectal Carcinoma
GDSC
PTTTS
DEG_SPOP_SBC_1
0.1944
p.T76I
SIDM00305
Ovarian Carcinoma
GDSC
PTTTS
DEG_SPOP_SBC_1
0.1944
p.T76I
SIDM00487
Colorectal Carcinoma
GDSC
PTTTS
DEG_SPOP_SBC_1
0.1944
p.T76I
SIDM00612
Glioma
GDSC
PTTTS
DEG_SPOP_SBC_1
0.1944
p.T76I
SIDM01575
Plasma Cell Myeloma
GDSC
PTTTS
DEG_SPOP_SBC_1
0.1944
p.G76E
U-266
haematopoietic_and_lymphoid_tissue
COSMIC
PTTTS
DEG_SPOP_SBC_1
0.1944
p.T75M
TCGA-AP-A059
UCEC
TCGA
PTTTS
DEG_SPOP_SBC_1
0.1667
p.T75M
SIDM00784
Glioma
GDSC
PTTTS
DEG_SPOP_SBC_1
0.1667
p.Q75L
KYSE-220
oesophagus
COSMIC
PTTTS
DEG_SPOP_SBC_1
0.1667
p.T93A
MFE-319
endometrium
COSMIC
PTTTS
DEG_SPOP_SBC_1
0.1111
Showing 1 to 13 of 13 entries
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Drug responses associated with CD68 mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
No data available in table
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All proteins holding degron of PTTTS
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9UBP5
Hairy/enhancer-of-split related with YRPW motif protein 2
DEG_SPOP_SBC_1
40:44
PTTTS
SPOP
0.8075
More...
Q96D42
Hepatitis A virus cellular receptor 1
DEG_SPOP_SBC_1
197:201
PTTTS
SPOP
0.9976
More...
P34810
Macrosialin
DEG_SPOP_SBC_1
81:85
PTTTS
SPOP
0.9583
More...
Q6ZSS7
Major facilitator superfamily domain-containing protein 6
DEG_SPOP_SBC_1
424:428
PTTTS
SPOP
0.5073
More...
Q96HA1
Nuclear envelope pore membrane protein POM 121
DEG_SPOP_SBC_1
761:765
PTTTS
SPOP
0.9806
More...
A8CG34
Nuclear envelope pore membrane protein POM 121C
DEG_SPOP_SBC_1
738:742
PTTTS
SPOP
0.9721
More...
Q9NZP6
Nuclear pore-associated protein 1
DEG_SPOP_SBC_1
883:887
PTTTS
SPOP
0.9896
More...
Q9Y618
Nuclear receptor corepressor 2
DEG_SPOP_SBC_1
1788:1792
PTTTS
SPOP
0.9962
More...
A6NF01
Putative nuclear envelope pore membrane protein POM 121B
DEG_SPOP_SBC_1
345:349
PTTTS
SPOP
0.9532
More...
A1A4S6
Rho GTPase-activating protein 10
DEG_SPOP_SBC_1
693:697
PTTTS
SPOP
0.9308
More...
Q9H987
Synaptopodin 2-like protein
DEG_SPOP_SBC_1
480:484
PTTTS
SPOP
0.9703
More...
Q9Y4F4
TOG array regulator of axonemal microtubules protein 1
DEG_SPOP_SBC_1
61:65
PTTTS
SPOP
0.9973
More...
Q5T0Z8
Uncharacterized protein C6orf132
DEG_SPOP_SBC_1
699:703
PTTTS
SPOP
0.9973
More...
Q5T0B9
Zinc finger protein 362
DEG_SPOP_SBC_1
148:152
PTTTS
SPOP
0.9988
More...
Showing 1 to 14 of 14 entries
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