DegronMD - P34810(CD68)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P40S	TCGA-A5-A0G2	UCEC	TCGA	VTPTVT	DEG_SCF_FBW7_1	38:43	Mutation altering degron motif	0.6752
p.P40S	DO41235	UCEC	ICGC	VTPTVT	DEG_SCF_FBW7_1	38:43	Mutation altering degron motif	0.6752
p.T75M	TCGA-AP-A059	UCEC	TCGA	PTTTS	DEG_SPOP_SBC_1	81:85	Mutation rewiring degron network	0.1667
p.T75M	SIDM00784	Glioma	GDSC	PTTTS	DEG_SPOP_SBC_1	81:85	Mutation rewiring degron network	0.1667
p.L32V	TCGA-EO-A22R	UCEC	TCGA	VTPTVT	DEG_SCF_FBW7_1	38:43	Mutation rewiring degron network	0.1667
p.L32V	DO42713	UCEC	ICGC	VTPTVT	DEG_SCF_FBW7_1	38:43	Mutation rewiring degron network	0.1667
p.T84S	TCGA-F1-6874	STAD	TCGA	PTTTS	DEG_SPOP_SBC_1	81:85	Mutation altering degron motif	0.6005
p.E44K	TCGA-PE-A5DE	BRCA	TCGA	VTPTVT	DEG_SCF_FBW7_1	38:43	Mutation rewiring degron network	0.3056
p.G46V	DO229027	LICA	ICGC	VTPTVT	DEG_SCF_FBW7_1	38:43	Mutation rewiring degron network	0.25
p.T125A	DO223282	UCEC	ICGC	PATTS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.0556
p.T48M	DO41361	UCEC	ICGC	VTPTVT	DEG_SCF_FBW7_1	38:43	Mutation rewiring degron network	0.1944
p.T76I	SIDM00215	Colorectal Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	81:85	Mutation rewiring degron network	0.1944
p.T76I	SIDM00305	Ovarian Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	81:85	Mutation rewiring degron network	0.1944
p.T76I	SIDM00487	Colorectal Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	81:85	Mutation rewiring degron network	0.1944
p.T76I	SIDM00612	Glioma	GDSC	PTTTS	DEG_SPOP_SBC_1	81:85	Mutation rewiring degron network	0.1944
p.T76I	SIDM01575	Plasma Cell Myeloma	GDSC	PTTTS	DEG_SPOP_SBC_1	81:85	Mutation rewiring degron network	0.1944
p.T83I	SIDM00232	Kidney Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	81:85	Mutation altering degron motif	0.7078
p.T83I	ACH-002168	Kidney Cancer	CCLE	PTTTS	DEG_SPOP_SBC_1	81:85	Mutation altering degron motif	0.7078
p.R52M	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	VTPTVT	DEG_SCF_FBW7_1	38:43	Mutation rewiring degron network	0.0833
p.R52M	ACH-002272	Lymphoma	CCLE	VTPTVT	DEG_SCF_FBW7_1	38:43	Mutation rewiring degron network	0.0833
p.R52M	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	VTPTVT	DEG_SCF_FBW7_1	38:43	Mutation rewiring degron network	0.0833
p.Q102L	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	PATTS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.0833
p.Q102L	ACH-002263	Esophageal Cancer	CCLE	PATTS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.0833
p.Q102L	KYSE-220	oesophagus	COSMIC	PATTS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.0833
p.S110G	SIDM00924	Other Solid Cancers	GDSC	PATTS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.3056
p.G103E	SIDM00417	Plasma Cell Myeloma	GDSC	PATTS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.1111
p.G103E	SIDM00526	Chronic Myelogenous Leukemia	GDSC	PATTS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.1111
p.G103E	U-266	haematopoietic and lymphoid tissue	COSMIC	PATTS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.1111
p.T120A	SIDM00333	Endometrial Carcinoma	GDSC	PATTS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.1944
p.T120A	ACH-000988	Endometrial/Uterine Cancer	CCLE	PATTS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.1944
p.T120A	MFE-319	endometrium	COSMIC	PATTS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.1944
p.T46I	SIDM00683	Prostate Carcinoma	GDSC	VTPTVT	DEG_SCF_FBW7_1	38:43	Mutation rewiring degron network	0.25
p.T46I	ACH-000977	lymph node	CCLE	VTPTVT	DEG_SCF_FBW7_1	38:43	Mutation rewiring degron network	0.25
p.T46I	LNCaP-Clone-FGC	prostate	COSMIC	VTPTVT	DEG_SCF_FBW7_1	38:43	Mutation rewiring degron network	0.25
p.T41M	SIDM00793	Burkitt's Lymphoma	GDSC	VTPTVT	DEG_SCF_FBW7_1	38:43	Mutation altering degron motif	0.6312
p.T41M	SIDM00785	Acute Myeloid Leukemia	GDSC	VTPTVT	DEG_SCF_FBW7_1	38:43	Mutation altering degron motif	0.6312
p.P120Q	MCF7	breast	COSMIC	PATTS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.1944
p.Q75L	KYSE-220	oesophagus	COSMIC	PTTTS	DEG_SPOP_SBC_1	81:85	Mutation rewiring degron network	0.1667
p.T93A	MFE-319	endometrium	COSMIC	PTTTS	DEG_SPOP_SBC_1	81:85	Mutation rewiring degron network	0.1111
p.G76E	U-266	haematopoietic and lymphoid tissue	COSMIC	PTTTS	DEG_SPOP_SBC_1	81:85	Mutation rewiring degron network	0.1944

Kaplan plot for CD68 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CD68

UniProt ID: P34810

Entrez ID: 968

Protein name: Macrosialin (Gp110) (CD antigen CD68)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CD68 in