DegronMD

Uniprot ID: P34810

Source protein: Macrosialin

Source gene: CD68

Class: DEG_SCF_FBW7_1

Location: 38:43

E3 ligase: FBXW7

DEGRON score: 0.6334

ASA_SCORE: 85.8333

COIL: 0.8923

CONS_SCORE: 0.7813

DSS_SCORE: 0.5006

HELIX: 0.0125

FCONS_SCORE: 0.9972

RIG_SCORE: 0.7268

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P40S	TCGA-A5-A0G2	UCEC	TCGA	VTPTVT	DEG_SCF_FBW7_1	0.6752
p.P40S	DO41235	UCEC	ICGC	VTPTVT	DEG_SCF_FBW7_1	0.6752
p.L32V	TCGA-EO-A22R	UCEC	TCGA	VTPTVT	DEG_SCF_FBW7_1	0.1667
p.L32V	DO42713	UCEC	ICGC	VTPTVT	DEG_SCF_FBW7_1	0.1667
p.E44K	TCGA-PE-A5DE	BRCA	TCGA	VTPTVT	DEG_SCF_FBW7_1	0.3056
p.G46V	DO229027	LICA	ICGC	VTPTVT	DEG_SCF_FBW7_1	0.25
p.T48M	DO41361	UCEC	ICGC	VTPTVT	DEG_SCF_FBW7_1	0.1944
p.R52M	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	VTPTVT	DEG_SCF_FBW7_1	0.0833
p.R52M	ACH-002272	Lymphoma	CCLE	VTPTVT	DEG_SCF_FBW7_1	0.0833
p.R52M	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	VTPTVT	DEG_SCF_FBW7_1	0.0833
p.T46I	SIDM00683	Prostate Carcinoma	GDSC	VTPTVT	DEG_SCF_FBW7_1	0.25
p.T46I	ACH-000977	lymph_node	CCLE	VTPTVT	DEG_SCF_FBW7_1	0.25
p.T46I	LNCaP-Clone-FGC	prostate	COSMIC	VTPTVT	DEG_SCF_FBW7_1	0.25
p.T41M	SIDM00793	Burkitt's Lymphoma	GDSC	VTPTVT	DEG_SCF_FBW7_1	0.6312
p.T41M	SIDM00785	Acute Myeloid Leukemia	GDSC	VTPTVT	DEG_SCF_FBW7_1	0.6312

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P34810	Macrosialin	DEG_SCF_FBW7_1	38:43	VTPTVT	FBXW7	0.6334	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons