NCOR2
UniProt ID: Q9Y618
Entrez ID: 9612
Protein name: Nuclear receptor corepressor 2 (N-CoR2) (CTG repeat protein 26) (SMAP270) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (T3 receptor-associating factor) (TRAC) (Thyroid-, retinoic-acid-receptor-associated corepressor)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Transcriptional corepressor (PubMed:20812024). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 4 have different affinities for different nuclear receptor...
FUNCTION: Transcriptional corepressor (PubMed:20812024). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 4 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). {ECO:0000269|PubMed:18212045, ECO:0000269|PubMed:20812024, ECO:0000269|PubMed:23911289}.
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GO - Biological processes (BP):
estrous cycle [GO:0044849]; lactation [GO:0007595]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of production of miRNAs involved in gene silencing by miRNA [GO:1903799]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regula...
estrous cycle [GO:0044849]; lactation [GO:0007595]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of production of miRNAs involved in gene silencing by miRNA [GO:1903799]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cellular ketone metabolic process [GO:0010565]; regulation of transcription by RNA polymerase II [GO:0006357]; response to estradiol [GO:0032355]; response to organonitrogen compound [GO:0010243]
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GO - Molecular function (MF):
chromatin binding [GO:0003682]; DNA binding [GO:0003677]; glucocorticoid receptor binding [GO:0035259]; histone deacetylase binding [GO:0042826]; Notch binding [GO:0005112]; protein-containing complex binding [GO:0044877]; protein N-terminus binding [GO:0047485]; retinoid X receptor binding [GO:0046...
chromatin binding [GO:0003682]; DNA binding [GO:0003677]; glucocorticoid receptor binding [GO:0035259]; histone deacetylase binding [GO:0042826]; Notch binding [GO:0005112]; protein-containing complex binding [GO:0044877]; protein N-terminus binding [GO:0047485]; retinoid X receptor binding [GO:0046965]; transcription corepressor activity [GO:0003714]
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GO - Cellular component (CC):
chromatin [GO:0000785]; membrane [GO:0016020]; nuclear body [GO:0016604]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]...
chromatin [GO:0000785]; membrane [GO:0016020]; nuclear body [GO:0016604]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]
NCOR2
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*NOTE: the Kaplan plots were collected from OncoLnc