DegronMD

Uniprot ID: Q9Y618

Source protein: Nuclear receptor corepressor 2

Source gene: NCOR2

Class: DEG_Kelch_actinfilin_1

Location: 1526:1530

E3 ligase: CUL3,KLHL17

DEGRON score: 0.9854

ASA_SCORE: 91.5

COIL: 0.9578

CONS_SCORE: 0.3938

DSS_SCORE: 0.5527

HELIX: 0.008

FCONS_SCORE: 1.1187

RIG_SCORE: 0.7404

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1537W	TCGA-A6-2686	COAD	TCGA	APVIV	DEG_Kelch_actinfilin_1	0.1389
p.R1537W	TCGA-G4-6588	COAD	TCGA	APVIV	DEG_Kelch_actinfilin_1	0.1389
p.K1520T	DO233731	GACA	ICGC	APVIV	DEG_Kelch_actinfilin_1	0.1667
p.L1518R	DO48665	SKCM	ICGC	APVIV	DEG_Kelch_actinfilin_1	0.5556
p.A1530T	DO48547	STAD	ICGC	APVIV	DEG_Kelch_actinfilin_1	0.7139
p.P1526S	DO229264	THCA	ICGC	APVIV	DEG_Kelch_actinfilin_1	0.6752
p.S1518T	SIDM00672	Hepatocellular Carcinoma	GDSC	APVIV	DEG_Kelch_actinfilin_1	0.5556
p.S1518T	SIDM00181	Bladder Carcinoma	GDSC	APVIV	DEG_Kelch_actinfilin_1	0.5556
p.S1518T	SIDM01709	Melanoma	GDSC	APVIV	DEG_Kelch_actinfilin_1	0.5556
p.R1524H	ACH-000748	Bone Cancer	CCLE	APVIV	DEG_Kelch_actinfilin_1	0.2778
p.R1524H	ACH-000800	Lung Cancer	CCLE	APVIV	DEG_Kelch_actinfilin_1	0.2778
p.A1526T	ACH-000885	Ovarian Cancer	CCLE	APVIV	DEG_Kelch_actinfilin_1	0.7139
p.V1530L	ACH-000892	Lung Cancer	CCLE	APVIV	DEG_Kelch_actinfilin_1	0.6765
p.S1518L	ACH-000936	Ovarian Cancer	CCLE	APVIV	DEG_Kelch_actinfilin_1	0.5556
p.R1524C	ACH-000990	Endometrial/Uterine Cancer	CCLE	APVIV	DEG_Kelch_actinfilin_1	0.2778
p.A1540T	23132-87	stomach	COSMIC	APVIV	DEG_Kelch_actinfilin_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13002	Glutamate receptor ionotropic, kainate 2	DEG_Kelch_actinfilin_1	881:885	APVIV	CUL3,KLHL17	0.9182	More...
Q6P158	Putative ATP-dependent RNA helicase DHX57	DEG_Kelch_actinfilin_1	487:491	APVIV	CUL3,KLHL17	0.9985	More...
Q9Y618	Nuclear receptor corepressor 2	DEG_Kelch_actinfilin_1	1526:1530	APVIV	CUL3,KLHL17	0.9854	More...
Q9UKY7	Protein CDV3 homolog	DEG_Kelch_actinfilin_1	152:156	APVIV	CUL3,KLHL17	0.9813	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons