DegronMD - Q6P158(DHX57)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V437L	TCGA-05-4417	LUAD	TCGA	NTHHKYSDPP	CBL_PTK	427:436	Mutation rewiring degron network	0.3056
p.V437L	DO23570	LUAD	ICGC	NTHHKYSDPP	CBL_PTK	427:436	Mutation rewiring degron network	0.3056
p.Y432C	TCGA-50-6590	LUAD	TCGA	NTHHKYSDPP	CBL_PTK	427:436	Mutation altering degron motif	0.7087
p.Y432C	DO24692	LUAD	ICGC	NTHHKYSDPP	CBL_PTK	427:436	Mutation altering degron motif	0.7087
p.G485C	TCGA-69-7763	LUAD	TCGA	APVIV	DEG_Kelch_actinfilin_1	487:491	Mutation rewiring degron network	0.2778
p.G485C	DO24616	LUAD	ICGC	APVIV	DEG_Kelch_actinfilin_1	487:491	Mutation rewiring degron network	0.2778
p.S419L	TCGA-AA-A010	COAD	TCGA	NTHHKYSDPP	CBL_PTK	427:436	Mutation rewiring degron network	0.1111
p.F64L	TCGA-B5-A3FA	UCEC	TCGA	FCIFSE	LIG_APCC_ABBA_1	64:69	Mutation altering degron motif	0.587
p.F64L	DO52402	UCEC	ICGC	FCIFSE	LIG_APCC_ABBA_1	64:69	Mutation altering degron motif	0.587
p.R72H	TCGA-CG-4442	STAD	TCGA	FCIFSE	LIG_APCC_ABBA_1	64:69	Mutation rewiring degron network	0.25
p.R72H	TCGA-EJ-7782	PRAD	TCGA	FCIFSE	LIG_APCC_ABBA_1	64:69	Mutation rewiring degron network	0.25
p.R72H	TCGA-FP-A4BF	STAD	TCGA	FCIFSE	LIG_APCC_ABBA_1	64:69	Mutation rewiring degron network	0.25
p.R72H	DO228138	PBCA	ICGC	FCIFSE	LIG_APCC_ABBA_1	64:69	Mutation rewiring degron network	0.25
p.R72H	DO36256	PRAD	ICGC	FCIFSE	LIG_APCC_ABBA_1	64:69	Mutation rewiring degron network	0.25
p.R72H	DO38380	STAD	ICGC	FCIFSE	LIG_APCC_ABBA_1	64:69	Mutation rewiring degron network	0.25
p.R72H	DO47775	STAD	ICGC	FCIFSE	LIG_APCC_ABBA_1	64:69	Mutation rewiring degron network	0.25
p.P443S	TCGA-EE-A29L	SKCM	TCGA	NTHHKYSDPP	CBL_PTK	427:436	Mutation rewiring degron network	0.1389
p.P443S	DO222599	MELA	ICGC	NTHHKYSDPP	CBL_PTK	427:436	Mutation rewiring degron network	0.1389
p.P443S	DO37835	SKCM	ICGC	NTHHKYSDPP	CBL_PTK	427:436	Mutation rewiring degron network	0.1389
p.P488L	TCGA-EE-A2MR	SKCM	TCGA	APVIV	DEG_Kelch_actinfilin_1	487:491	Mutation altering degron motif	0.7582
p.P488L	DO37819	SKCM	ICGC	APVIV	DEG_Kelch_actinfilin_1	487:491	Mutation altering degron motif	0.7582
p.R72L	TCGA-IH-A3EA	SKCM	TCGA	FCIFSE	LIG_APCC_ABBA_1	64:69	Mutation rewiring degron network	0.25
p.R72L	DO37667	SKCM	ICGC	FCIFSE	LIG_APCC_ABBA_1	64:69	Mutation rewiring degron network	0.25
p.F64C	TCGA-ND-A4WC	UCS	TCGA	FCIFSE	LIG_APCC_ABBA_1	64:69	Mutation altering degron motif	0.7108
p.D434N	TCGA-VQ-A91D	STAD	TCGA	NTHHKYSDPP	CBL_PTK	427:436	Mutation altering degron motif	0.5821
p.D434N	DO51783	STAD	ICGC	NTHHKYSDPP	CBL_PTK	427:436	Mutation altering degron motif	0.5821
p.T426K	DO228974	LICA	ICGC	NTHHKYSDPP	CBL_PTK	427:436	Mutation rewiring degron network	0.3056
p.H429N	DO228978	LICA	ICGC	NTHHKYSDPP	CBL_PTK	427:436	Mutation altering degron motif	0.6312
p.V497M	DO50883	LICA	ICGC	APVIV	DEG_Kelch_actinfilin_1	487:491	Mutation rewiring degron network	0.1667
p.P486L	DO222363	MELA	ICGC	APVIV	DEG_Kelch_actinfilin_1	487:491	Mutation rewiring degron network	0.3056
p.S477F	DO229465	SKCA	ICGC	APVIV	DEG_Kelch_actinfilin_1	487:491	Mutation blocking phosphorylation signal	0.5
p.E482D	SIDM00131	Glioma	GDSC	APVIV	DEG_Kelch_actinfilin_1	487:491	Mutation rewiring degron network	0.1944
p.E482D	ACH-000329	Brain Cancer	CCLE	APVIV	DEG_Kelch_actinfilin_1	487:491	Mutation rewiring degron network	0.1944
p.E482D	CCF-STTG1	central nervous system	COSMIC	APVIV	DEG_Kelch_actinfilin_1	487:491	Mutation rewiring degron network	0.1944
p.S433G	SIDM00967	Ovarian Carcinoma	GDSC	NTHHKYSDPP	CBL_PTK	427:436	Mutation altering degron motif	0.6993
p.S433G	SIDM00863	Burkitt's Lymphoma	GDSC	NTHHKYSDPP	CBL_PTK	427:436	Mutation altering degron motif	0.6993
p.S433G	SIDM01664	Prostate Carcinoma	GDSC	NTHHKYSDPP	CBL_PTK	427:436	Mutation altering degron motif	0.6993
p.S433G	SIDM01409	Bladder Carcinoma	GDSC	NTHHKYSDPP	CBL_PTK	427:436	Mutation altering degron motif	0.6993
p.S433G	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	NTHHKYSDPP	CBL_PTK	427:436	Mutation altering degron motif	0.6993
p.I66M	SIDM01229	Neuroblastoma	GDSC	FCIFSE	LIG_APCC_ABBA_1	64:69	Mutation altering degron motif	0.6507
p.I66M	ACH-000312	Neuroblastoma	CCLE	FCIFSE	LIG_APCC_ABBA_1	64:69	Mutation altering degron motif	0.6507
p.I66M	ACH-002217	Neuroblastoma	CCLE	FCIFSE	LIG_APCC_ABBA_1	64:69	Mutation altering degron motif	0.6507
p.I66M	BE2-M17	autonomic ganglia	COSMIC	FCIFSE	LIG_APCC_ABBA_1	64:69	Mutation altering degron motif	0.6507
p.R72C	SIDM00220	Ovarian Carcinoma	GDSC	FCIFSE	LIG_APCC_ABBA_1	64:69	Mutation rewiring degron network	0.25
p.R72C	ACH-000962	Ovarian Cancer	CCLE	FCIFSE	LIG_APCC_ABBA_1	64:69	Mutation rewiring degron network	0.25
p.R72C	ACH-001145	Ovarian Cancer	CCLE	FCIFSE	LIG_APCC_ABBA_1	64:69	Mutation rewiring degron network	0.25
p.R72C	OC-314	ovary	COSMIC	FCIFSE	LIG_APCC_ABBA_1	64:69	Mutation rewiring degron network	0.25
p.K500R	SIDM01739	Small Cell Lung Carcinoma	GDSC	APVIV	DEG_Kelch_actinfilin_1	487:491	Mutation substituting flanking lysine	0.1944
p.K500R	ACH-000297	Lung Cancer	CCLE	APVIV	DEG_Kelch_actinfilin_1	487:491	Mutation substituting flanking lysine	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DHX57

UniProt ID: Q6P158

Entrez ID: 90957

Protein name: Putative ATP-dependent RNA helicase DHX57 (EC 3.6.4.13) (DEAH box protein 57)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DHX57 in