DegronMD

Uniprot ID: Q6P158

Source protein: Putative ATP-dependent RNA helicase DHX57

Source gene: DHX57

Class: LIG_APCC_ABBA_1

Location: 64:69

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6053

ASA_SCORE: 64.95

COIL: 0.564

CONS_SCORE: 0.2941

DSS_SCORE: 0.5582

HELIX: 0.1732

FCONS_SCORE: 1.0242

RIG_SCORE: 0.8189

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F64L	TCGA-B5-A3FA	UCEC	TCGA	FCIFSE	LIG_APCC_ABBA_1	0.587
p.F64L	DO52402	UCEC	ICGC	FCIFSE	LIG_APCC_ABBA_1	0.587
p.R72H	TCGA-CG-4442	STAD	TCGA	FCIFSE	LIG_APCC_ABBA_1	0.25
p.R72H	TCGA-EJ-7782	PRAD	TCGA	FCIFSE	LIG_APCC_ABBA_1	0.25
p.R72H	TCGA-FP-A4BF	STAD	TCGA	FCIFSE	LIG_APCC_ABBA_1	0.25
p.R72H	DO228138	PBCA	ICGC	FCIFSE	LIG_APCC_ABBA_1	0.25
p.R72H	DO36256	PRAD	ICGC	FCIFSE	LIG_APCC_ABBA_1	0.25
p.R72H	DO38380	STAD	ICGC	FCIFSE	LIG_APCC_ABBA_1	0.25
p.R72H	DO47775	STAD	ICGC	FCIFSE	LIG_APCC_ABBA_1	0.25
p.R72L	TCGA-IH-A3EA	SKCM	TCGA	FCIFSE	LIG_APCC_ABBA_1	0.25
p.R72L	DO37667	SKCM	ICGC	FCIFSE	LIG_APCC_ABBA_1	0.25
p.F64C	TCGA-ND-A4WC	UCS	TCGA	FCIFSE	LIG_APCC_ABBA_1	0.7108
p.I66M	SIDM01229	Neuroblastoma	GDSC	FCIFSE	LIG_APCC_ABBA_1	0.6507
p.I66M	ACH-000312	Neuroblastoma	CCLE	FCIFSE	LIG_APCC_ABBA_1	0.6507
p.I66M	ACH-002217	Neuroblastoma	CCLE	FCIFSE	LIG_APCC_ABBA_1	0.6507
p.I66M	BE2-M17	autonomic_ganglia	COSMIC	FCIFSE	LIG_APCC_ABBA_1	0.6507
p.R72C	SIDM00220	Ovarian Carcinoma	GDSC	FCIFSE	LIG_APCC_ABBA_1	0.25
p.R72C	ACH-000962	Ovarian Cancer	CCLE	FCIFSE	LIG_APCC_ABBA_1	0.25
p.R72C	ACH-001145	Ovarian Cancer	CCLE	FCIFSE	LIG_APCC_ABBA_1	0.25
p.R72C	OC-314	ovary	COSMIC	FCIFSE	LIG_APCC_ABBA_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6P158	Putative ATP-dependent RNA helicase DHX57	LIG_APCC_ABBA_1	64:69	FCIFSE	APC,CDC20,FZR1	0.6053	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons