DegronMD

Uniprot ID: Q6P158

Source protein: Putative ATP-dependent RNA helicase DHX57

Source gene: DHX57

Class: DEG_Kelch_actinfilin_1

Location: 487:491

E3 ligase: CUL3,KLHL17

DEGRON score: 0.9985

ASA_SCORE: 74.86

COIL: 0.8648

CONS_SCORE: 0.2395

DSS_SCORE: 0.577

HELIX: 0.0562

FCONS_SCORE: 0.9075

RIG_SCORE: 0.7549

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G485C	TCGA-69-7763	LUAD	TCGA	APVIV	DEG_Kelch_actinfilin_1	0.2778
p.G485C	DO24616	LUAD	ICGC	APVIV	DEG_Kelch_actinfilin_1	0.2778
p.P488L	TCGA-EE-A2MR	SKCM	TCGA	APVIV	DEG_Kelch_actinfilin_1	0.7582
p.P488L	DO37819	SKCM	ICGC	APVIV	DEG_Kelch_actinfilin_1	0.7582
p.V497M	DO50883	LICA	ICGC	APVIV	DEG_Kelch_actinfilin_1	0.1667
p.P486L	DO222363	MELA	ICGC	APVIV	DEG_Kelch_actinfilin_1	0.3056
p.S477F	DO229465	SKCA	ICGC	APVIV	DEG_Kelch_actinfilin_1	0.5
p.E482D	SIDM00131	Glioma	GDSC	APVIV	DEG_Kelch_actinfilin_1	0.1944
p.E482D	ACH-000329	Brain Cancer	CCLE	APVIV	DEG_Kelch_actinfilin_1	0.1944
p.E482D	CCF-STTG1	central_nervous_system	COSMIC	APVIV	DEG_Kelch_actinfilin_1	0.1944
p.K500R	SIDM01739	Small Cell Lung Carcinoma	GDSC	APVIV	DEG_Kelch_actinfilin_1	0.1944
p.K500R	ACH-000297	Lung Cancer	CCLE	APVIV	DEG_Kelch_actinfilin_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13002	Glutamate receptor ionotropic, kainate 2	DEG_Kelch_actinfilin_1	881:885	APVIV	CUL3,KLHL17	0.9182	More...
Q6P158	Putative ATP-dependent RNA helicase DHX57	DEG_Kelch_actinfilin_1	487:491	APVIV	CUL3,KLHL17	0.9985	More...
Q9Y618	Nuclear receptor corepressor 2	DEG_Kelch_actinfilin_1	1526:1530	APVIV	CUL3,KLHL17	0.9854	More...
Q9UKY7	Protein CDV3 homolog	DEG_Kelch_actinfilin_1	152:156	APVIV	CUL3,KLHL17	0.9813	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons