DegronMD

Uniprot ID: Q13002

Source protein: Glutamate receptor ionotropic, kainate 2

Source gene: GRIK2

Class: DEG_Kelch_actinfilin_1

Location: 881:885

E3 ligase: CUL3,KLHL17

DEGRON score: 0.9182

ASA_SCORE: 95.58

COIL: 0.9282

CONS_SCORE: 0.2706

DSS_SCORE: 0.3868

HELIX: 0.0306

FCONS_SCORE: 0.9591

RIG_SCORE: 0.7704

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P879Q	TCGA-43-2581	LUSC	TCGA	APVIV	DEG_Kelch_actinfilin_1	0.2778
p.Q880H	TCGA-66-2773	LUSC	TCGA	APVIV	DEG_Kelch_actinfilin_1	0.3056
p.Q880H	DO26536	LUSC	ICGC	APVIV	DEG_Kelch_actinfilin_1	0.3056
p.R873C	TCGA-AA-A02R	COAD	TCGA	APVIV	DEG_Kelch_actinfilin_1	0.1111
p.R873C	TCGA-OE-A75W	PAAD	TCGA	APVIV	DEG_Kelch_actinfilin_1	0.1111
p.R873C	DO230342	COCA	ICGC	APVIV	DEG_Kelch_actinfilin_1	0.1111
p.R873C	DO50265	PAAD	ICGC	APVIV	DEG_Kelch_actinfilin_1	0.1111
p.R874Q	TCGA-AB-2919	LAML	TCGA	APVIV	DEG_Kelch_actinfilin_1	0.1389
p.N892S	TCGA-AJ-A3EL	UCEC	TCGA	APVIV	DEG_Kelch_actinfilin_1	0.1389
p.N892S	DO41542	UCEC	ICGC	APVIV	DEG_Kelch_actinfilin_1	0.1389
p.E889K	TCGA-DD-A11D	LIHC	TCGA	APVIV	DEG_Kelch_actinfilin_1	0.2222
p.E889K	DO23010	LIHC	ICGC	APVIV	DEG_Kelch_actinfilin_1	0.2222
p.P882T	TCGA-EE-A2A6	SKCM	TCGA	APVIV	DEG_Kelch_actinfilin_1	0.7031
p.P882T	DO37591	SKCM	ICGC	APVIV	DEG_Kelch_actinfilin_1	0.7031
p.V885L	TCGA-EI-6881	READ	TCGA	APVIV	DEG_Kelch_actinfilin_1	0.6765
p.V885L	DO37098	READ	ICGC	APVIV	DEG_Kelch_actinfilin_1	0.6765
p.R874P	TCGA-L9-A444	LUAD	TCGA	APVIV	DEG_Kelch_actinfilin_1	0.1389
p.P879S	TCGA-RB-AA9M	PAAD	TCGA	APVIV	DEG_Kelch_actinfilin_1	0.2778
p.P879S	DO51718	PAAD	ICGC	APVIV	DEG_Kelch_actinfilin_1	0.2778
p.E889V	DO234278	ESAD	ICGC	APVIV	DEG_Kelch_actinfilin_1	0.2222
p.S889P	DO223124	ESCA	ICGC	APVIV	DEG_Kelch_actinfilin_1	0.2222
p.S874F	DO49666	LIAD	ICGC	APVIV	DEG_Kelch_actinfilin_1	0.1389
p.C871F	DO228952	LICA	ICGC	APVIV	DEG_Kelch_actinfilin_1	0.0556
p.E871D	DO45167	LIRI	ICGC	APVIV	DEG_Kelch_actinfilin_1	0.0556
p.P883L	DO230530	LUSC	ICGC	APVIV	DEG_Kelch_actinfilin_1	0.7582
p.L875V	DO52686	MALY	ICGC	APVIV	DEG_Kelch_actinfilin_1	0.1667
p.E888K	DO222837	MELA	ICGC	APVIV	DEG_Kelch_actinfilin_1	0.25
p.E871Q	DO36888	READ	ICGC	APVIV	DEG_Kelch_actinfilin_1	0.0556
p.S889L	DO229462	SKCA	ICGC	APVIV	DEG_Kelch_actinfilin_1	0.2222
p.L875F	SIDM00845	Burkitt's Lymphoma	GDSC	APVIV	DEG_Kelch_actinfilin_1	0.1667
p.L875F	SIDM00946	T-Lymphoblastic Leukemia	GDSC	APVIV	DEG_Kelch_actinfilin_1	0.1667
p.L875F	ACH-000786	Lymphoma	CCLE	APVIV	DEG_Kelch_actinfilin_1	0.1667
p.L875F	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	APVIV	DEG_Kelch_actinfilin_1	0.1667
p.S886L	SIDM01060	Melanoma	GDSC	APVIV	DEG_Kelch_actinfilin_1	0.3056
p.M893I	SIDM00780	Colorectal Carcinoma	GDSC	APVIV	DEG_Kelch_actinfilin_1	0.1111
p.M893I	ACH-000967	Colon/Colorectal Cancer	CCLE	APVIV	DEG_Kelch_actinfilin_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13002	Glutamate receptor ionotropic, kainate 2	DEG_Kelch_actinfilin_1	881:885	APVIV	CUL3,KLHL17	0.9182	More...
Q6P158	Putative ATP-dependent RNA helicase DHX57	DEG_Kelch_actinfilin_1	487:491	APVIV	CUL3,KLHL17	0.9985	More...
Q9Y618	Nuclear receptor corepressor 2	DEG_Kelch_actinfilin_1	1526:1530	APVIV	CUL3,KLHL17	0.9854	More...
Q9UKY7	Protein CDV3 homolog	DEG_Kelch_actinfilin_1	152:156	APVIV	CUL3,KLHL17	0.9813	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: APVIV

Degron related mutations and impact score

Drug responses associated with GRIK2 mutations

All proteins holding degron of APVIV