DegronMD

Uniprot ID: Q9UKY7

Source protein: Protein CDV3 homolog

Source gene: CDV3

Class: DEG_Kelch_actinfilin_1

Location: 152:156

E3 ligase: CUL3,KLHL17

DEGRON score: 0.9813

ASA_SCORE: 84.76

COIL: 0.9

CONS_SCORE: 0.5378

DSS_SCORE: 0.6334

HELIX: 0.0178

FCONS_SCORE: 0.8528

RIG_SCORE: 0.7304

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V147I	TCGA-AJ-A3EK	UCEC	TCGA	APVIV	DEG_Kelch_actinfilin_1	0.1944
p.V147I	DO41584	UCEC	ICGC	APVIV	DEG_Kelch_actinfilin_1	0.1944
p.P153S	DO52438	COCA	ICGC	APVIV	DEG_Kelch_actinfilin_1	0.6752
p.P153S	SIDM00434	Plasma Cell Myeloma	GDSC	APVIV	DEG_Kelch_actinfilin_1	0.6752
p.P153S	SIDM00231	Kidney Carcinoma	GDSC	APVIV	DEG_Kelch_actinfilin_1	0.6752
p.P153S	SIDM00543	Melanoma	GDSC	APVIV	DEG_Kelch_actinfilin_1	0.6752
p.P153S	SIDM00161	Biliary Tract Carcinoma	GDSC	APVIV	DEG_Kelch_actinfilin_1	0.6752
p.A149S	DO50737	LICA	ICGC	APVIV	DEG_Kelch_actinfilin_1	0.25
p.P151H	DO229253	THCA	ICGC	APVIV	DEG_Kelch_actinfilin_1	0.3056
p.P151S	SIDM00516	Melanoma	GDSC	APVIV	DEG_Kelch_actinfilin_1	0.3056
p.P151S	MZ7-mel	skin	COSMIC	APVIV	DEG_Kelch_actinfilin_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13002	Glutamate receptor ionotropic, kainate 2	DEG_Kelch_actinfilin_1	881:885	APVIV	CUL3,KLHL17	0.9182	More...
Q6P158	Putative ATP-dependent RNA helicase DHX57	DEG_Kelch_actinfilin_1	487:491	APVIV	CUL3,KLHL17	0.9985	More...
Q9Y618	Nuclear receptor corepressor 2	DEG_Kelch_actinfilin_1	1526:1530	APVIV	CUL3,KLHL17	0.9854	More...
Q9UKY7	Protein CDV3 homolog	DEG_Kelch_actinfilin_1	152:156	APVIV	CUL3,KLHL17	0.9813	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons