DegronMD

Uniprot ID: Q6P158

Source protein: Putative ATP-dependent RNA helicase DHX57

Source gene: DHX57

Class: CBL_PTK

Location: 427:436

E3 ligase: CBL

DEGRON score: 0.9662

ASA_SCORE: 81.81

COIL: 0.7502

CONS_SCORE: 0.2834

DSS_SCORE: 0.3282

HELIX: 0.2112

FCONS_SCORE: 1.1514

RIG_SCORE: 0.737

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V437L	TCGA-05-4417	LUAD	TCGA	NTHHKYSDPP	CBL_PTK	0.3056
p.V437L	DO23570	LUAD	ICGC	NTHHKYSDPP	CBL_PTK	0.3056
p.Y432C	TCGA-50-6590	LUAD	TCGA	NTHHKYSDPP	CBL_PTK	0.7087
p.Y432C	DO24692	LUAD	ICGC	NTHHKYSDPP	CBL_PTK	0.7087
p.S419L	TCGA-AA-A010	COAD	TCGA	NTHHKYSDPP	CBL_PTK	0.1111
p.P443S	TCGA-EE-A29L	SKCM	TCGA	NTHHKYSDPP	CBL_PTK	0.1389
p.P443S	DO222599	MELA	ICGC	NTHHKYSDPP	CBL_PTK	0.1389
p.P443S	DO37835	SKCM	ICGC	NTHHKYSDPP	CBL_PTK	0.1389
p.D434N	TCGA-VQ-A91D	STAD	TCGA	NTHHKYSDPP	CBL_PTK	0.5821
p.D434N	DO51783	STAD	ICGC	NTHHKYSDPP	CBL_PTK	0.5821
p.T426K	DO228974	LICA	ICGC	NTHHKYSDPP	CBL_PTK	0.3056
p.H429N	DO228978	LICA	ICGC	NTHHKYSDPP	CBL_PTK	0.6312
p.S433G	SIDM00967	Ovarian Carcinoma	GDSC	NTHHKYSDPP	CBL_PTK	0.6993
p.S433G	SIDM00863	Burkitt's Lymphoma	GDSC	NTHHKYSDPP	CBL_PTK	0.6993
p.S433G	SIDM01664	Prostate Carcinoma	GDSC	NTHHKYSDPP	CBL_PTK	0.6993
p.S433G	SIDM01409	Bladder Carcinoma	GDSC	NTHHKYSDPP	CBL_PTK	0.6993
p.S433G	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	NTHHKYSDPP	CBL_PTK	0.6993

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6P158	Putative ATP-dependent RNA helicase DHX57	CBL_PTK	427:436	NTHHKYSDPP	CBL	0.9662	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons