DegronMD

Uniprot ID: Q9Y618

Source protein: Nuclear receptor corepressor 2

Source gene: NCOR2

Class: DEG_SCF_FBW7_2

Location: 796:801

E3 ligase: FBXW7

DEGRON score: 0.8851

ASA_SCORE: 91.8167

COIL: 0.9248

CONS_SCORE: 0.2904

DSS_SCORE: 0.9006

HELIX: 0.0558

FCONS_SCORE: 0.9118

RIG_SCORE: 0.5132

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T797A	TCGA-A6-5665	COAD	TCGA	PTPASE	DEG_SCF_FBW7_2	0.7139
p.T803I	TCGA-DX-AB2V	SARC	TCGA	PTPASE	DEG_SCF_FBW7_2	0.7222
p.P802A	DO26240	LUAD	ICGC	PTPASE	DEG_SCF_FBW7_2	0.3056
p.E807K	DO26818	LUSC	ICGC	PTPASE	DEG_SCF_FBW7_2	0.6111
p.P802S	DO37843	SKCM	ICGC	PTPASE	DEG_SCF_FBW7_2	0.3056
p.G804R	SIDM00098	Mesothelioma	GDSC	PTPASE	DEG_SCF_FBW7_2	0.25
p.G804R	ACH-002129	Lung Cancer	CCLE	PTPASE	DEG_SCF_FBW7_2	0.25
p.P791L	SIDM01102	Non-Cancerous	GDSC	PTPASE	DEG_SCF_FBW7_2	0.1944
p.P791L	ACH-002316	Non-Cancerous	CCLE	PTPASE	DEG_SCF_FBW7_2	0.1944
p.P791L	WIL2-NS	haematopoietic_and_lymphoid_tissue	COSMIC	PTPASE	DEG_SCF_FBW7_2	0.1944
p.P798L	ACH-000860	Lung Cancer	CCLE	PTPASE	DEG_SCF_FBW7_2	0.7582
p.E795K	ACH-001369	Ovarian Cancer	CCLE	PTPASE	DEG_SCF_FBW7_2	0.3056
p.R791H	ME-1	haematopoietic_and_lymphoid_tissue	COSMIC	PTPASE	DEG_SCF_FBW7_2	0.1944
p.R791H	TC-YIK	cervix	COSMIC	PTPASE	DEG_SCF_FBW7_2	0.1944
p.R791H	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	PTPASE	DEG_SCF_FBW7_2	0.1944
p.R791H	BFTC-909	kidney	COSMIC	PTPASE	DEG_SCF_FBW7_2	0.1944
p.R791H	RKN	ovary	COSMIC	PTPASE	DEG_SCF_FBW7_2	0.1944
p.E797K	SNU-81	large_intestine	COSMIC	PTPASE	DEG_SCF_FBW7_2	0.7022
p.G806S	ETK-1	biliary_tract	COSMIC	PTPASE	DEG_SCF_FBW7_2	0.1944
p.R802C	U031	kidney	COSMIC	PTPASE	DEG_SCF_FBW7_2	0.3056
p.L803F	SNU-175	large_intestine	COSMIC	PTPASE	DEG_SCF_FBW7_2	0.7222
p.L803F	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	PTPASE	DEG_SCF_FBW7_2	0.7222
p.R805H	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	PTPASE	DEG_SCF_FBW7_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y618	Nuclear receptor corepressor 2	DEG_SCF_FBW7_2	796:801	PTPASE	FBXW7	0.8851	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons