DegronMD

Uniprot ID: Q9Y618

Source protein: Nuclear receptor corepressor 2

Source gene: NCOR2

Class: DEG_SCF_FBW7_2

Location: 782:788

E3 ligase: FBXW7

DEGRON score: 0.9965

ASA_SCORE: 101.4143

COIL: 0.9697

CONS_SCORE: 0.3344

DSS_SCORE: 0.9395

HELIX: 0.0131

FCONS_SCORE: 1.1824

RIG_SCORE: 0.4481

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P785L	TCGA-EE-A2MS	SKCM	TCGA	PPTPPPE	DEG_SCF_FBW7_2	0.7582
p.G777R	TCGA-FI-A2D0	UCEC	TCGA	PPTPPPE	DEG_SCF_FBW7_2	0.1944
p.G777R	SIDM00793	Burkitt's Lymphoma	GDSC	PPTPPPE	DEG_SCF_FBW7_2	0.1944
p.G777R	EB-3	haematopoietic_and_lymphoid_tissue	COSMIC	PPTPPPE	DEG_SCF_FBW7_2	0.1944
p.T779A	DO9756	COAD	ICGC	PPTPPPE	DEG_SCF_FBW7_2	0.25
p.A787G	DO46606	OV	ICGC	PPTPPPE	DEG_SCF_FBW7_2	0.754
p.T785I	DO220093	SARC	ICGC	PPTPPPE	DEG_SCF_FBW7_2	0.7078
p.T776P	DO229268	THCA	ICGC	PPTPPPE	DEG_SCF_FBW7_2	0.1667
p.P791L	SIDM01102	Non-Cancerous	GDSC	PPTPPPE	DEG_SCF_FBW7_2	0.25
p.P791L	ACH-002316	Non-Cancerous	CCLE	PPTPPPE	DEG_SCF_FBW7_2	0.25
p.P791L	WIL2-NS	haematopoietic_and_lymphoid_tissue	COSMIC	PPTPPPE	DEG_SCF_FBW7_2	0.25
p.P785T	SIDM01059	Melanoma	GDSC	PPTPPPE	DEG_SCF_FBW7_2	0.7031
p.P785T	ACH-000915	Skin Cancer	CCLE	PPTPPPE	DEG_SCF_FBW7_2	0.7031
p.P785T	IPC-298	skin	COSMIC	PPTPPPE	DEG_SCF_FBW7_2	0.7031
p.E795K	ACH-001369	Ovarian Cancer	CCLE	PPTPPPE	DEG_SCF_FBW7_2	0.1389
p.G777E	ACH-002023	Colon/Colorectal Cancer	CCLE	PPTPPPE	DEG_SCF_FBW7_2	0.1944
p.R774H	RKN	ovary	COSMIC	PPTPPPE	DEG_SCF_FBW7_2	0.1111
p.R774H	ME-1	haematopoietic_and_lymphoid_tissue	COSMIC	PPTPPPE	DEG_SCF_FBW7_2	0.1111
p.R774H	BFTC-909	kidney	COSMIC	PPTPPPE	DEG_SCF_FBW7_2	0.1111
p.R774H	TC-YIK	cervix	COSMIC	PPTPPPE	DEG_SCF_FBW7_2	0.1111
p.R774H	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	PPTPPPE	DEG_SCF_FBW7_2	0.1111
p.P773L	WIL2-NS	haematopoietic_and_lymphoid_tissue	COSMIC	PPTPPPE	DEG_SCF_FBW7_2	0.0833
p.R791H	ME-1	haematopoietic_and_lymphoid_tissue	COSMIC	PPTPPPE	DEG_SCF_FBW7_2	0.25
p.R791H	TC-YIK	cervix	COSMIC	PPTPPPE	DEG_SCF_FBW7_2	0.25
p.R791H	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	PPTPPPE	DEG_SCF_FBW7_2	0.25
p.R791H	BFTC-909	kidney	COSMIC	PPTPPPE	DEG_SCF_FBW7_2	0.25
p.R791H	RKN	ovary	COSMIC	PPTPPPE	DEG_SCF_FBW7_2	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPTPPPE

Degron related mutations and impact score

Drug responses associated with NCOR2 mutations

All proteins holding degron of PPTPPPE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y618	Nuclear receptor corepressor 2	DEG_SCF_FBW7_2	782:788	PPTPPPE	FBXW7	0.9965	More...