DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
PPTPPPE
Uniprot ID:
Q9Y618
Source protein:
Nuclear receptor corepressor 2
Source gene:
NCOR2
Class:
DEG_SCF_FBW7_2
Location:
782:788
E3 ligase:
FBXW7
DEGRON score:
0.9965
ASA_SCORE:
101.4143
COIL:
0.9697
CONS_SCORE:
0.3344
DSS_SCORE:
0.9395
HELIX:
0.0131
FCONS_SCORE:
1.1824
RIG_SCORE:
0.4481
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P785L
TCGA-EE-A2MS
SKCM
TCGA
PPTPPPE
DEG_SCF_FBW7_2
0.7582
p.A787G
DO46606
OV
ICGC
PPTPPPE
DEG_SCF_FBW7_2
0.754
p.T785I
DO220093
SARC
ICGC
PPTPPPE
DEG_SCF_FBW7_2
0.7078
p.P785T
SIDM01059
Melanoma
GDSC
PPTPPPE
DEG_SCF_FBW7_2
0.7031
p.P785T
ACH-000915
Skin Cancer
CCLE
PPTPPPE
DEG_SCF_FBW7_2
0.7031
p.P785T
IPC-298
skin
COSMIC
PPTPPPE
DEG_SCF_FBW7_2
0.7031
p.T779A
DO9756
COAD
ICGC
PPTPPPE
DEG_SCF_FBW7_2
0.25
p.P791L
SIDM01102
Non-Cancerous
GDSC
PPTPPPE
DEG_SCF_FBW7_2
0.25
p.P791L
ACH-002316
Non-Cancerous
CCLE
PPTPPPE
DEG_SCF_FBW7_2
0.25
p.P791L
WIL2-NS
haematopoietic_and_lymphoid_tissue
COSMIC
PPTPPPE
DEG_SCF_FBW7_2
0.25
p.R791H
ME-1
haematopoietic_and_lymphoid_tissue
COSMIC
PPTPPPE
DEG_SCF_FBW7_2
0.25
p.R791H
TC-YIK
cervix
COSMIC
PPTPPPE
DEG_SCF_FBW7_2
0.25
p.R791H
CML-T1
haematopoietic_and_lymphoid_tissue
COSMIC
PPTPPPE
DEG_SCF_FBW7_2
0.25
p.R791H
BFTC-909
kidney
COSMIC
PPTPPPE
DEG_SCF_FBW7_2
0.25
p.R791H
RKN
ovary
COSMIC
PPTPPPE
DEG_SCF_FBW7_2
0.25
p.G777R
TCGA-FI-A2D0
UCEC
TCGA
PPTPPPE
DEG_SCF_FBW7_2
0.1944
p.G777R
SIDM00793
Burkitt's Lymphoma
GDSC
PPTPPPE
DEG_SCF_FBW7_2
0.1944
p.G777R
EB-3
haematopoietic_and_lymphoid_tissue
COSMIC
PPTPPPE
DEG_SCF_FBW7_2
0.1944
p.G777E
ACH-002023
Colon/Colorectal Cancer
CCLE
PPTPPPE
DEG_SCF_FBW7_2
0.1944
p.T776P
DO229268
THCA
ICGC
PPTPPPE
DEG_SCF_FBW7_2
0.1667
p.E795K
ACH-001369
Ovarian Cancer
CCLE
PPTPPPE
DEG_SCF_FBW7_2
0.1389
p.R774H
RKN
ovary
COSMIC
PPTPPPE
DEG_SCF_FBW7_2
0.1111
p.R774H
ME-1
haematopoietic_and_lymphoid_tissue
COSMIC
PPTPPPE
DEG_SCF_FBW7_2
0.1111
p.R774H
BFTC-909
kidney
COSMIC
PPTPPPE
DEG_SCF_FBW7_2
0.1111
p.R774H
TC-YIK
cervix
COSMIC
PPTPPPE
DEG_SCF_FBW7_2
0.1111
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Drug responses associated with NCOR2 mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
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All proteins holding degron of PPTPPPE
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9Y618
Nuclear receptor corepressor 2
DEG_SCF_FBW7_2
782:788
PPTPPPE
FBXW7
0.9965
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