DegronMD

Uniprot ID: Q9Y618

Source protein: Nuclear receptor corepressor 2

Source gene: NCOR2

Class: DEG_APCC_DBOX_1

Location: 106:114

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9393

ASA_SCORE: 102.0222

COIL: 0.7603

CONS_SCORE: 0.4139

DSS_SCORE: 0.4695

HELIX: 0.178

FCONS_SCORE: 1.088

RIG_SCORE: 0.7418

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P122S	TCGA-43-2578	LUSC	TCGA	KRPRLELLP	DEG_APCC_DBOX_1	0.1111
p.P122S	DO26662	LUSC	ICGC	KRPRLELLP	DEG_APCC_DBOX_1	0.1111
p.R119Q	TCGA-AP-A0LM	UCEC	TCGA	KRPRLELLP	DEG_APCC_DBOX_1	0.1944
p.R119Q	DO43306	UCEC	ICGC	KRPRLELLP	DEG_APCC_DBOX_1	0.1944
p.K97T	TCGA-AZ-4315	COAD	TCGA	KRPRLELLP	DEG_APCC_DBOX_1	0.1944
p.K97T	DO8842	COAD	ICGC	KRPRLELLP	DEG_APCC_DBOX_1	0.1944
p.R107H	TCGA-EO-A22U	UCEC	TCGA	KRPRLELLP	DEG_APCC_DBOX_1	0.8244
p.R107H	TCGA-VQ-AA6D	STAD	TCGA	KRPRLELLP	DEG_APCC_DBOX_1	0.8244
p.R107H	DO233624	GACA	ICGC	KRPRLELLP	DEG_APCC_DBOX_1	0.8244
p.R107H	DO222392	STAD	ICGC	KRPRLELLP	DEG_APCC_DBOX_1	0.8244
p.R107H	DO43755	UCEC	ICGC	KRPRLELLP	DEG_APCC_DBOX_1	0.8244
p.R107H	ACH-000995	Leukemia	CCLE	KRPRLELLP	DEG_APCC_DBOX_1	0.8244
p.R107C	TCGA-EO-A3AZ	UCEC	TCGA	KRPRLELLP	DEG_APCC_DBOX_1	0.8301
p.R107C	DO50078	UCEC	ICGC	KRPRLELLP	DEG_APCC_DBOX_1	0.8301
p.M100I	DO233944	GACA	ICGC	KRPRLELLP	DEG_APCC_DBOX_1	0.1667
p.E111A	DO232761	PBCA	ICGC	KRPRLELLP	DEG_APCC_DBOX_1	0.659
p.K106Q	SIDM00578	Neuroblastoma	GDSC	KRPRLELLP	DEG_APCC_DBOX_1	0.5833
p.K106Q	ACH-000804	Neuroblastoma	CCLE	KRPRLELLP	DEG_APCC_DBOX_1	0.5833
p.S105G	SIDM00574	Glioblastoma	GDSC	KRPRLELLP	DEG_APCC_DBOX_1	0.3056
p.S105G	SIDM00616	Hepatocellular Carcinoma	GDSC	KRPRLELLP	DEG_APCC_DBOX_1	0.3056
p.S105G	SIDM01033	Bladder Carcinoma	GDSC	KRPRLELLP	DEG_APCC_DBOX_1	0.3056
p.S105G	SIDM01695	Acute Myeloid Leukemia	GDSC	KRPRLELLP	DEG_APCC_DBOX_1	0.3056
p.S105G	SIDM01442	Glioma	GDSC	KRPRLELLP	DEG_APCC_DBOX_1	0.3056
p.L124V	ACH-000943	Colon/Colorectal Cancer	CCLE	KRPRLELLP	DEG_APCC_DBOX_1	0.0556
p.E100K	GP5d	large_intestine	COSMIC	KRPRLELLP	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y618	Nuclear receptor corepressor 2	DEG_APCC_DBOX_1	106:114	KRPRLELLP	APC,CDC20,FZR1	0.9393	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KRPRLELLP

Degron related mutations and impact score

Drug responses associated with NCOR2 mutations

All proteins holding degron of KRPRLELLP