DegronMD

Uniprot ID: Q9Y618

Source protein: Nuclear receptor corepressor 2

Source gene: NCOR2

Class: DEG_SCF_FBW7_1

Location: 596:601

E3 ligase: FBXW7

DEGRON score: 0.9808

ASA_SCORE: 89.35

COIL: 0.7325

CONS_SCORE: 0.4284

DSS_SCORE: 0.6349

HELIX: 0.249

FCONS_SCORE: 1.1635

RIG_SCORE: 0.7062

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E608D	TCGA-86-7955	LUAD	TCGA	ITPQQS	DEG_SCF_FBW7_1	0.1389
p.T597I	TCGA-A8-A09B	BRCA	TCGA	ITPQQS	DEG_SCF_FBW7_1	0.7078
p.T597A	TCGA-A8-A09B	BRCA	TCGA	ITPQQS	DEG_SCF_FBW7_1	0.7139
p.S592N	TCGA-AJ-A23O	UCEC	TCGA	ITPQQS	DEG_SCF_FBW7_1	0.2222
p.E608A	TCGA-BR-6452	STAD	TCGA	ITPQQS	DEG_SCF_FBW7_1	0.1389
p.Q599H	TCGA-BR-6452	STAD	TCGA	ITPQQS	DEG_SCF_FBW7_1	0.647
p.E611K	TCGA-NJ-A4YP	LUAD	TCGA	ITPQQS	DEG_SCF_FBW7_1	0.0556
p.T596I	DO1653	BRCA	ICGC	ITPQQS	DEG_SCF_FBW7_1	0.7078
p.T596A	DO1653	BRCA	ICGC	ITPQQS	DEG_SCF_FBW7_1	0.7139
p.A604D	DO229019	LICA	ICGC	ITPQQS	DEG_SCF_FBW7_1	0.25
p.S591R	DO229006	LICA	ICGC	ITPQQS	DEG_SCF_FBW7_1	0.1944
p.E610K	DO218943	LUAD	ICGC	ITPQQS	DEG_SCF_FBW7_1	0.0833
p.E607D	DO23612	LUAD	ICGC	ITPQQS	DEG_SCF_FBW7_1	0.1667
p.E607A	DO38404	STAD	ICGC	ITPQQS	DEG_SCF_FBW7_1	0.1667
p.Q598H	DO38404	STAD	ICGC	ITPQQS	DEG_SCF_FBW7_1	0.7582
p.Q598K	DO229253	THCA	ICGC	ITPQQS	DEG_SCF_FBW7_1	0.6944
p.A601V	DO229268	THCA	ICGC	ITPQQS	DEG_SCF_FBW7_1	0.6936
p.S591N	DO43290	UCEC	ICGC	ITPQQS	DEG_SCF_FBW7_1	0.1944
p.V605M	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	ITPQQS	DEG_SCF_FBW7_1	0.2222
p.E609K	MCF7	breast	COSMIC	ITPQQS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y618	Nuclear receptor corepressor 2	DEG_SCF_FBW7_1	596:601	ITPQQS	FBXW7	0.9808	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons