DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
ESLGVPTA
Uniprot ID:
Q9Y618
Source protein:
Nuclear receptor corepressor 2
Source gene:
NCOR2
Class:
DEG_COP1_1
Location:
1182:1189
E3 ligase:
COP1
DEGRON score:
0.9982
ASA_SCORE:
80.4625
COIL:
0.9089
CONS_SCORE:
0.3612
DSS_SCORE:
0.6498
HELIX:
0.0524
FCONS_SCORE:
1.001
RIG_SCORE:
0.665
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R1177W
DO10880
GBM
ICGC
ESLGVPTA
DEG_COP1_1
0.1944
p.P1180T
DO228978
LICA
ICGC
ESLGVPTA
DEG_COP1_1
0.2778
p.P1177H
DO229035
LICA
ICGC
ESLGVPTA
DEG_COP1_1
0.1944
p.A1199D
DO27893
ORCA
ICGC
ESLGVPTA
DEG_COP1_1
0.0556
p.R1186C
DO51407
PRAD
ICGC
ESLGVPTA
DEG_COP1_1
0.8301
p.R1186C
DO41133
UCEC
ICGC
ESLGVPTA
DEG_COP1_1
0.8301
p.I1189V
DO229240
THCA
ICGC
ESLGVPTA
DEG_COP1_1
0.7076
p.G1179E
DO229088
THCA
ICGC
ESLGVPTA
DEG_COP1_1
0.25
p.V1186M
SIDM00422
Hodgkin's Lymphoma
GDSC
ESLGVPTA
DEG_COP1_1
0.7208
p.R1175Q
SIDM00527
Colorectal Carcinoma
GDSC
ESLGVPTA
DEG_COP1_1
0.1389
p.R1175Q
ACH-000935
Colon/Colorectal Cancer
CCLE
ESLGVPTA
DEG_COP1_1
0.1389
p.E1191K
SIDM00006
Other Solid Cancers
GDSC
ESLGVPTA
DEG_COP1_1
0.2778
p.E1191K
ACH-001552
Skin Cancer
CCLE
ESLGVPTA
DEG_COP1_1
0.2778
p.E1191K
MCC26
skin
COSMIC
ESLGVPTA
DEG_COP1_1
0.2778
p.A1195S
MHH-NB-11
autonomic_ganglia
COSMIC
ESLGVPTA
DEG_COP1_1
0.1667
p.P1172H
LS-411N
large_intestine
COSMIC
ESLGVPTA
DEG_COP1_1
0.0556
p.G1195A
GR-ST
haematopoietic_and_lymphoid_tissue
COSMIC
ESLGVPTA
DEG_COP1_1
0.1667
p.E1181K
MCC26
skin
COSMIC
ESLGVPTA
DEG_COP1_1
0.3056
p.R1181W
SW684
soft_tissue
COSMIC
ESLGVPTA
DEG_COP1_1
0.3056
p.P1194L
TE-11
oesophagus
COSMIC
ESLGVPTA
DEG_COP1_1
0.1944
p.L1188M
CW-2
large_intestine
COSMIC
ESLGVPTA
DEG_COP1_1
0.711
p.G1188S
RCC-ER
kidney
COSMIC
ESLGVPTA
DEG_COP1_1
0.6993
Drug responses associated with NCOR2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of ESLGVPTA
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9Y618
Nuclear receptor corepressor 2
DEG_COP1_1
1182:1189
ESLGVPTA
COP1
0.9982
More...