DegronMD

Uniprot ID: A1A4S6

Source protein: Rho GTPase-activating protein 10

Source gene: ARHGAP10

Class: DEG_SPOP_SBC_1

Location: 693:697

E3 ligase: SPOP

DEGRON score: 0.9308

ASA_SCORE: 87.5

COIL: 0.9348

CONS_SCORE: 0.3648

DSS_SCORE: 0.5859

HELIX: 0.0426

FCONS_SCORE: 0.9959

RIG_SCORE: 0.6142

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S683F	TCGA-B5-A11E	UCEC	TCGA	PTTTS	DEG_SPOP_SBC_1	0.0556
p.S683F	DO41644	UCEC	ICGC	PTTTS	DEG_SPOP_SBC_1	0.0556
p.T695I	TCGA-DI-A1BU	UCEC	TCGA	PTTTS	DEG_SPOP_SBC_1	0.7078
p.T695I	DO42023	UCEC	ICGC	PTTTS	DEG_SPOP_SBC_1	0.7078
p.P693T	TCGA-FI-A2D5	UCEC	TCGA	PTTTS	DEG_SPOP_SBC_1	0.7031
p.P693T	DO41331	UCEC	ICGC	PTTTS	DEG_SPOP_SBC_1	0.7031
p.S706L	TCGA-YD-A9TA	SKCM	TCGA	PTTTS	DEG_SPOP_SBC_1	0.0833
p.S706L	DO219503	SKCM	ICGC	PTTTS	DEG_SPOP_SBC_1	0.0833
p.S700L	TCGA-YG-AA3O	SKCM	TCGA	PTTTS	DEG_SPOP_SBC_1	0.25
p.S700L	DO51299	SKCM	ICGC	PTTTS	DEG_SPOP_SBC_1	0.25
p.L688F	DO234154	ESAD	ICGC	PTTTS	DEG_SPOP_SBC_1	0.1944
p.S692F	DO234443	ESAD	ICGC	PTTTS	DEG_SPOP_SBC_1	0.3056
p.T703A	SIDM01090	Colorectal Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.1667
p.T703A	SIDM00309	Mesothelioma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.1667
p.S698P	ACH-000628	Lung Cancer	CCLE	PTTTS	DEG_SPOP_SBC_1	0.3056
p.S698P	NCI-H596	lung	COSMIC	PTTTS	DEG_SPOP_SBC_1	0.3056
p.N689I	ACH-002287	Colon/Colorectal Cancer	CCLE	PTTTS	DEG_SPOP_SBC_1	0.2222
p.N689I	NCI-H630	large_intestine	COSMIC	PTTTS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A1A4S6	Rho GTPase-activating protein 10	DEG_SPOP_SBC_1	693:697	PTTTS	SPOP	0.9308	More...
A8CG34	Nuclear envelope pore membrane protein POM 121C	DEG_SPOP_SBC_1	738:742	PTTTS	SPOP	0.9721	More...
P34810	Macrosialin	DEG_SPOP_SBC_1	81:85	PTTTS	SPOP	0.9583	More...
Q6ZSS7	Major facilitator superfamily domain-containing protein 6	DEG_SPOP_SBC_1	424:428	PTTTS	SPOP	0.5073	More...
Q96D42	Hepatitis A virus cellular receptor 1	DEG_SPOP_SBC_1	197:201	PTTTS	SPOP	0.9976	More...
Q96HA1	Nuclear envelope pore membrane protein POM 121	DEG_SPOP_SBC_1	761:765	PTTTS	SPOP	0.9806	More...
Q9H987	Synaptopodin 2-like protein	DEG_SPOP_SBC_1	480:484	PTTTS	SPOP	0.9703	More...
Q9NZP6	Nuclear pore-associated protein 1	DEG_SPOP_SBC_1	883:887	PTTTS	SPOP	0.9896	More...
Q9UBP5	Hairy/enhancer-of-split related with YRPW motif protein 2	DEG_SPOP_SBC_1	40:44	PTTTS	SPOP	0.8075	More...
Q9Y4F4	TOG array regulator of axonemal microtubules protein 1	DEG_SPOP_SBC_1	61:65	PTTTS	SPOP	0.9973	More...
Q9Y618	Nuclear receptor corepressor 2	DEG_SPOP_SBC_1	1788:1792	PTTTS	SPOP	0.9962	More...
Q5T0B9	Zinc finger protein 362	DEG_SPOP_SBC_1	148:152	PTTTS	SPOP	0.9988	More...
A6NF01	Putative nuclear envelope pore membrane protein POM 121B	DEG_SPOP_SBC_1	345:349	PTTTS	SPOP	0.9532	More...
Q5T0Z8	Uncharacterized protein C6orf132	DEG_SPOP_SBC_1	699:703	PTTTS	SPOP	0.9973	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons