DegronMD - Q9H987(SYNPO2L)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P730T	TCGA-66-2795	LUSC	TCGA	SRGLLDGLV	DEG_APCC_DBOX_1	731:739	Mutation rewiring degron network	0.3056
p.P730T	DO26710	LUSC	ICGC	SRGLLDGLV	DEG_APCC_DBOX_1	731:739	Mutation rewiring degron network	0.3056
p.P515H	TCGA-95-7043	LUAD	TCGA	PTPLPS	DEG_SCF_FBW7_1	515:520	Mutation altering degron motif	0.7694
p.P515H	DO24739	LUAD	ICGC	PTPLPS	DEG_SCF_FBW7_1	515:520	Mutation altering degron motif	0.7694
p.S585Y	TCGA-AA-A010	COAD	TCGA	AMTST	DEG_SPOP_SBC_1	575:579	Mutation rewiring degron network	0.1667
p.A586V	TCGA-AA-A02R	COAD	TCGA	AMTST	DEG_SPOP_SBC_1	575:579	Mutation rewiring degron network	0.1389
p.A586V	DO217822	GACA	ICGC	AMTST	DEG_SPOP_SBC_1	575:579	Mutation rewiring degron network	0.1389
p.R395C	TCGA-AO-A0JI	BRCA	TCGA	ADSST	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.25
p.R395C	DO2043	BRCA	ICGC	ADSST	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.25
p.R407W	TCGA-AP-A051	UCEC	TCGA	ADSST	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1944
p.R407W	DO42673	UCEC	ICGC	ADSST	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1944
p.L734F	TCGA-AP-A0LM	UCEC	TCGA	SRGLLDGLV	DEG_APCC_DBOX_1	731:739	Mutation altering degron motif	0.587
p.L734F	DO43306	UCEC	ICGC	SRGLLDGLV	DEG_APCC_DBOX_1	731:739	Mutation altering degron motif	0.587
p.S745L	TCGA-AX-A2HC	UCEC	TCGA	SRGLLDGLV	DEG_APCC_DBOX_1	731:739	Mutation rewiring degron network	0.1667
p.S745L	DO36556	READ	ICGC	SRGLLDGLV	DEG_APCC_DBOX_1	731:739	Mutation rewiring degron network	0.1667
p.S745L	DO41572	UCEC	ICGC	SRGLLDGLV	DEG_APCC_DBOX_1	731:739	Mutation rewiring degron network	0.1667
p.S745L	SIDM00059	Ovarian Carcinoma	GDSC	SRGLLDGLV	DEG_APCC_DBOX_1	731:739	Mutation rewiring degron network	0.1667
p.S745L	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	SRGLLDGLV	DEG_APCC_DBOX_1	731:739	Mutation rewiring degron network	0.1667
p.S578F	TCGA-CG-4460	STAD	TCGA	AMTST	DEG_SPOP_SBC_1	575:579	Mutation altering degron motif	0.7982
p.S578F	DO38427	STAD	ICGC	AMTST	DEG_SPOP_SBC_1	575:579	Mutation altering degron motif	0.7982
p.I919T	TCGA-CS-4942	LGG	TCGA	TELASAPVPSP	DEG_COP1_1	922:932	Mutation rewiring degron network	0.25
p.I919T	DO22173	LGG	ICGC	TELASAPVPSP	DEG_COP1_1	922:932	Mutation rewiring degron network	0.25
p.Q513R	TCGA-D7-A6EY	STAD	TCGA	PTPLPS	DEG_SCF_FBW7_1	515:520	Mutation rewiring degron network	0.2778
p.Q513R	DO50118	STAD	ICGC	PTPLPS	DEG_SCF_FBW7_1	515:520	Mutation rewiring degron network	0.2778
p.V485I	TCGA-EE-A2GR	SKCM	TCGA	PTTTS	DEG_SPOP_SBC_1	480:484	Mutation rewiring degron network	0.3056
p.V485I	DO37996	SKCM	ICGC	PTTTS	DEG_SPOP_SBC_1	480:484	Mutation rewiring degron network	0.3056
p.Q403K	TCGA-EE-A3AD	SKCM	TCGA	ADSST	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.3056
p.Q403K	DO37707	SKCM	ICGC	ADSST	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.3056
p.P473L	TCGA-EO-A22U	UCEC	TCGA	PTTTS	DEG_SPOP_SBC_1	480:484	Mutation rewiring degron network	0.1389
p.P473L	DO43755	UCEC	ICGC	PTTTS	DEG_SPOP_SBC_1	480:484	Mutation rewiring degron network	0.1389
p.G733R	TCGA-FR-A726	SKCM	TCGA	SRGLLDGLV	DEG_APCC_DBOX_1	731:739	Mutation altering degron motif	0.6457
p.G733R	DO48665	SKCM	ICGC	SRGLLDGLV	DEG_APCC_DBOX_1	731:739	Mutation altering degron motif	0.6457
p.A743V	TCGA-HU-A4GT	STAD	TCGA	SRGLLDGLV	DEG_APCC_DBOX_1	731:739	Mutation rewiring degron network	0.2222
p.A743V	DO48020	STAD	ICGC	SRGLLDGLV	DEG_APCC_DBOX_1	731:739	Mutation rewiring degron network	0.2222
p.G454A	TCGA-HU-A4GU	STAD	TCGA	PTPAPS	DEG_SCF_FBW7_1	457:462	Mutation rewiring degron network	0.25
p.G454A	DO47849	STAD	ICGC	PTPAPS	DEG_SCF_FBW7_1	457:462	Mutation rewiring degron network	0.25
p.Q393H	TCGA-IB-7651	PAAD	TCGA	ADSST	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1944
p.Q393H	DO46657	PAAD	ICGC	ADSST	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1944
p.P730S	TCGA-QB-AA9O	SKCM	TCGA	SRGLLDGLV	DEG_APCC_DBOX_1	731:739	Mutation rewiring degron network	0.3056
p.P730S	DO51267	SKCM	ICGC	SRGLLDGLV	DEG_APCC_DBOX_1	731:739	Mutation rewiring degron network	0.3056
p.A460V	TCGA-W3-AA1V	SKCM	TCGA	PTPAPS	DEG_SCF_FBW7_1	457:462	Mutation altering degron motif	0.5825
p.A460V	DO51276	SKCM	ICGC	PTPAPS	DEG_SCF_FBW7_1	457:462	Mutation altering degron motif	0.5825
p.A575V	DO225388	BRCA	ICGC	AMTST	DEG_SPOP_SBC_1	575:579	Mutation altering degron motif	0.5825
p.P459S	DO222454	BTCA	ICGC	PTPAPS	DEG_SCF_FBW7_1	457:462	Mutation altering degron motif	0.6752
p.P459S	DO233882	GACA	ICGC	PTPAPS	DEG_SCF_FBW7_1	457:462	Mutation altering degron motif	0.6752
p.S462I	DO6690	CLLE	ICGC	PTPAPS	DEG_SCF_FBW7_1	457:462	Mutation altering degron motif	0.7341
p.A742S	DO227709	COCA	ICGC	SRGLLDGLV	DEG_APCC_DBOX_1	731:739	Mutation rewiring degron network	0.25
p.P473S	DO222864	COCA	ICGC	PTTTS	DEG_SPOP_SBC_1	480:484	Mutation rewiring degron network	0.1389
p.P461L	DO234401	ESAD	ICGC	PTPAPS	DEG_SCF_FBW7_1	457:462	Mutation altering degron motif	0.6471
p.S744C	DO223029	ESCA	ICGC	SRGLLDGLV	DEG_APCC_DBOX_1	731:739	Mutation rewiring degron network	0.1944
p.R479Q	DO233622	GACA	ICGC	PTTTS	DEG_SPOP_SBC_1	480:484	Mutation rewiring degron network	0.3056
p.G474C	DO17178	KIRC	ICGC	PTTTS	DEG_SPOP_SBC_1	480:484	Mutation rewiring degron network	0.1667
p.P449R	DO229353	LAML	ICGC	PTPAPS	DEG_SCF_FBW7_1	457:462	Mutation rewiring degron network	0.1111
p.P508H	DO229505	LAML	ICGC	PTPLPS	DEG_SCF_FBW7_1	515:520	Mutation rewiring degron network	0.1389
p.A468D	DO231957	LICA	ICGC	PTPAPS	DEG_SCF_FBW7_1	457:462	Mutation rewiring degron network	0.1667
p.A575D	DO228976	LICA	ICGC	AMTST	DEG_SPOP_SBC_1	575:579	Mutation altering degron motif	0.7793
p.V544M	DO228991	LICA	ICGC	PSTPRSS	DEG_SCF_FBW7_1	535:541	Mutation rewiring degron network	0.25
p.A726D	DO229018	LICA	ICGC	SRGLLDGLV	DEG_APCC_DBOX_1	731:739	Mutation rewiring degron network	0.1944
p.A412D	DO229029	LICA	ICGC	ADSST	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.0556
p.S578T	DO228419	MALY	ICGC	AMTST	DEG_SPOP_SBC_1	575:579	Mutation altering degron motif	0.6005
p.R488Q	DO35083	PACA	ICGC	PTTTS	DEG_SPOP_SBC_1	480:484	Mutation rewiring degron network	0.2222
p.P567S	SIDM00509	Small Cell Lung Carcinoma	GDSC	AMTST	DEG_SPOP_SBC_1	575:579	Mutation rewiring degron network	0.1111
p.T721A	SIDM00958	Chronic Myelogenous Leukemia	GDSC	SRGLLDGLV	DEG_APCC_DBOX_1	731:739	Mutation blocking phosphorylation signal	0.5
p.T721A	ACH-000920	Leukemia	CCLE	SRGLLDGLV	DEG_APCC_DBOX_1	731:739	Mutation blocking phosphorylation signal	0.5
p.T721A	CML-T1	haematopoietic and lymphoid tissue	COSMIC	SRGLLDGLV	DEG_APCC_DBOX_1	731:739	Mutation blocking phosphorylation signal	0.5
p.P571H	SIDM00683	Prostate Carcinoma	GDSC	AMTST	DEG_SPOP_SBC_1	575:579	Mutation rewiring degron network	0.2222
p.P571H	ACH-000977	lymph node	CCLE	AMTST	DEG_SPOP_SBC_1	575:579	Mutation rewiring degron network	0.2222
p.P571H	LNCaP-Clone-FGC	prostate	COSMIC	AMTST	DEG_SPOP_SBC_1	575:579	Mutation rewiring degron network	0.2222
p.V408I	SIDM01007	T-Lymphoblastic Leukemia	GDSC	ADSST	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1667
p.V408I	ACH-002256	Leukemia	CCLE	ADSST	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1667
p.V408I	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	ADSST	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1667
p.S581Y	SIDM01588	Endometrial Carcinoma	GDSC	AMTST	DEG_SPOP_SBC_1	575:579	Mutation rewiring degron network	0.2778
p.S581Y	ACH-000993	Endometrial/Uterine Cancer	CCLE	AMTST	DEG_SPOP_SBC_1	575:579	Mutation rewiring degron network	0.2778
p.V725M	ACH-001560	Lung Cancer	CCLE	SRGLLDGLV	DEG_APCC_DBOX_1	731:739	Mutation rewiring degron network	0.1667
p.M412L	DMS-53	lung	COSMIC	ADSST	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.0556
p.A486T	SK-UT-1	soft tissue	COSMIC	PTTTS	DEG_SPOP_SBC_1	480:484	Mutation rewiring degron network	0.2778
p.V549M	LIM1215	large intestine	COSMIC	PSTPRSS	DEG_SCF_FBW7_1	535:541	Mutation rewiring degron network	0.1111
p.R747K	SW962	vulva	COSMIC	SRGLLDGLV	DEG_APCC_DBOX_1	731:739	Mutation rewiring degron network	0.1111
p.P573H	CTV-1	haematopoietic and lymphoid tissue	COSMIC	AMTST	DEG_SPOP_SBC_1	575:579	Mutation rewiring degron network	0.2778
p.E458D	CW-2	large intestine	COSMIC	PTPAPS	DEG_SCF_FBW7_1	457:462	Mutation altering degron motif	0.6758
p.R544H	MOLT-13	haematopoietic and lymphoid tissue	COSMIC	PSTPRSS	DEG_SCF_FBW7_1	535:541	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SYNPO2L

UniProt ID: Q9H987

Entrez ID: 79933

Protein name: Synaptopodin 2-like protein

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SYNPO2L in