DegronMD

Uniprot ID: Q9H987

Source protein: Synaptopodin 2-like protein

Source gene: SYNPO2L

Class: DEG_SCF_FBW7_1

Location: 515:520

E3 ligase: FBXW7

DEGRON score: 0.9826

ASA_SCORE: 86.5833

COIL: 0.958

CONS_SCORE: 0.4363

DSS_SCORE: 0.615

HELIX: 0.0227

FCONS_SCORE: 0.8982

RIG_SCORE: 0.5646

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P515H	TCGA-95-7043	LUAD	TCGA	PTPLPS	DEG_SCF_FBW7_1	0.7694
p.P515H	DO24739	LUAD	ICGC	PTPLPS	DEG_SCF_FBW7_1	0.7694
p.Q513R	TCGA-D7-A6EY	STAD	TCGA	PTPLPS	DEG_SCF_FBW7_1	0.2778
p.Q513R	DO50118	STAD	ICGC	PTPLPS	DEG_SCF_FBW7_1	0.2778
p.P508H	DO229505	LAML	ICGC	PTPLPS	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H987	Synaptopodin 2-like protein	DEG_SCF_FBW7_1	515:520	PTPLPS	FBXW7	0.9826	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons