DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
TELASAPVPSP
Uniprot ID:
Q9H987
Source protein:
Synaptopodin 2-like protein
Source gene:
SYNPO2L
Class:
DEG_COP1_1
Location:
922:932
E3 ligase:
COP1
DEGRON score:
0.9565
ASA_SCORE:
87.2091
COIL:
0.8768
CONS_SCORE:
0.565
DSS_SCORE:
0.6205
HELIX:
0.1111
FCONS_SCORE:
0.9786
RIG_SCORE:
0.6619
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.I919T
TCGA-CS-4942
LGG
TCGA
TELASAPVPSP
DEG_COP1_1
0.25
p.I919T
DO22173
LGG
ICGC
TELASAPVPSP
DEG_COP1_1
0.25
Drug responses associated with SYNPO2L mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of TELASAPVPSP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9H987
Synaptopodin 2-like protein
DEG_COP1_1
922:932
TELASAPVPSP
COP1
0.9565
More...