DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
SRGLLDGLV
Uniprot ID:
Q9H987
Source protein:
Synaptopodin 2-like protein
Source gene:
SYNPO2L
Class:
DEG_APCC_DBOX_1
Location:
731:739
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.6555
ASA_SCORE:
88.0333
COIL:
0.8742
CONS_SCORE:
0.4495
DSS_SCORE:
0.6455
HELIX:
0.0937
FCONS_SCORE:
0.9439
RIG_SCORE:
0.6546
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P730T
TCGA-66-2795
LUSC
TCGA
SRGLLDGLV
DEG_APCC_DBOX_1
0.3056
p.P730T
DO26710
LUSC
ICGC
SRGLLDGLV
DEG_APCC_DBOX_1
0.3056
p.L734F
TCGA-AP-A0LM
UCEC
TCGA
SRGLLDGLV
DEG_APCC_DBOX_1
0.587
p.L734F
DO43306
UCEC
ICGC
SRGLLDGLV
DEG_APCC_DBOX_1
0.587
p.S745L
TCGA-AX-A2HC
UCEC
TCGA
SRGLLDGLV
DEG_APCC_DBOX_1
0.1667
p.S745L
DO36556
READ
ICGC
SRGLLDGLV
DEG_APCC_DBOX_1
0.1667
p.S745L
DO41572
UCEC
ICGC
SRGLLDGLV
DEG_APCC_DBOX_1
0.1667
p.S745L
SIDM00059
Ovarian Carcinoma
GDSC
SRGLLDGLV
DEG_APCC_DBOX_1
0.1667
p.S745L
SIDM00755
Non-Small Cell Lung Carcinoma
GDSC
SRGLLDGLV
DEG_APCC_DBOX_1
0.1667
p.G733R
TCGA-FR-A726
SKCM
TCGA
SRGLLDGLV
DEG_APCC_DBOX_1
0.6457
p.G733R
DO48665
SKCM
ICGC
SRGLLDGLV
DEG_APCC_DBOX_1
0.6457
p.A743V
TCGA-HU-A4GT
STAD
TCGA
SRGLLDGLV
DEG_APCC_DBOX_1
0.2222
p.A743V
DO48020
STAD
ICGC
SRGLLDGLV
DEG_APCC_DBOX_1
0.2222
p.P730S
TCGA-QB-AA9O
SKCM
TCGA
SRGLLDGLV
DEG_APCC_DBOX_1
0.3056
p.P730S
DO51267
SKCM
ICGC
SRGLLDGLV
DEG_APCC_DBOX_1
0.3056
p.A742S
DO227709
COCA
ICGC
SRGLLDGLV
DEG_APCC_DBOX_1
0.25
p.S744C
DO223029
ESCA
ICGC
SRGLLDGLV
DEG_APCC_DBOX_1
0.1944
p.A726D
DO229018
LICA
ICGC
SRGLLDGLV
DEG_APCC_DBOX_1
0.1944
p.T721A
SIDM00958
Chronic Myelogenous Leukemia
GDSC
SRGLLDGLV
DEG_APCC_DBOX_1
0.5
p.T721A
ACH-000920
Leukemia
CCLE
SRGLLDGLV
DEG_APCC_DBOX_1
0.5
p.T721A
CML-T1
haematopoietic_and_lymphoid_tissue
COSMIC
SRGLLDGLV
DEG_APCC_DBOX_1
0.5
p.V725M
ACH-001560
Lung Cancer
CCLE
SRGLLDGLV
DEG_APCC_DBOX_1
0.1667
p.R747K
SW962
vulva
COSMIC
SRGLLDGLV
DEG_APCC_DBOX_1
0.1111
Drug responses associated with SYNPO2L mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of SRGLLDGLV
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9H987
Synaptopodin 2-like protein
DEG_APCC_DBOX_1
731:739
SRGLLDGLV
APC,CDC20,FZR1
0.6555
More...