DegronMD

Uniprot ID: Q9H987

Source protein: Synaptopodin 2-like protein

Source gene: SYNPO2L

Class: DEG_SPOP_SBC_1

Location: 575:579

E3 ligase: SPOP

DEGRON score: 0.9382

ASA_SCORE: 79.1

COIL: 0.8144

CONS_SCORE: 0.4482

DSS_SCORE: 0.5827

HELIX: 0.1518

FCONS_SCORE: 0.9133

RIG_SCORE: 0.6691

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S585Y	TCGA-AA-A010	COAD	TCGA	AMTST	DEG_SPOP_SBC_1	0.1667
p.A586V	TCGA-AA-A02R	COAD	TCGA	AMTST	DEG_SPOP_SBC_1	0.1389
p.A586V	DO217822	GACA	ICGC	AMTST	DEG_SPOP_SBC_1	0.1389
p.S578F	TCGA-CG-4460	STAD	TCGA	AMTST	DEG_SPOP_SBC_1	0.7982
p.S578F	DO38427	STAD	ICGC	AMTST	DEG_SPOP_SBC_1	0.7982
p.A575V	DO225388	BRCA	ICGC	AMTST	DEG_SPOP_SBC_1	0.5825
p.A575D	DO228976	LICA	ICGC	AMTST	DEG_SPOP_SBC_1	0.7793
p.S578T	DO228419	MALY	ICGC	AMTST	DEG_SPOP_SBC_1	0.6005
p.P567S	SIDM00509	Small Cell Lung Carcinoma	GDSC	AMTST	DEG_SPOP_SBC_1	0.1111
p.P571H	SIDM00683	Prostate Carcinoma	GDSC	AMTST	DEG_SPOP_SBC_1	0.2222
p.P571H	ACH-000977	lymph_node	CCLE	AMTST	DEG_SPOP_SBC_1	0.2222
p.P571H	LNCaP-Clone-FGC	prostate	COSMIC	AMTST	DEG_SPOP_SBC_1	0.2222
p.S581Y	SIDM01588	Endometrial Carcinoma	GDSC	AMTST	DEG_SPOP_SBC_1	0.2778
p.S581Y	ACH-000993	Endometrial/Uterine Cancer	CCLE	AMTST	DEG_SPOP_SBC_1	0.2778
p.P573H	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	AMTST	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1380:1384	AMTST	SPOP	0.6573	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	3003:3007	AMTST	SPOP	0.95	More...
Q9H987	Synaptopodin 2-like protein	DEG_SPOP_SBC_1	575:579	AMTST	SPOP	0.9382	More...
Q9NP60	X-linked interleukin-1 receptor accessory protein-like 2	DEG_SPOP_SBC_1	588:592	AMTST	SPOP	0.5216	More...
Q9UGU0	Transcription factor 20	DEG_SPOP_SBC_1	1463:1467	AMTST	SPOP	0.5189	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons