DegronMD

Uniprot ID: Q9UGU0

Source protein: Transcription factor 20

Source gene: TCF20

Class: DEG_SPOP_SBC_1

Location: 1463:1467

E3 ligase: SPOP

DEGRON score: 0.5189

ASA_SCORE: 85.22

COIL: 0.8278

CONS_SCORE: 0.4171

DSS_SCORE: 0.8007

HELIX: 0.0362

FCONS_SCORE: 0.9465

RIG_SCORE: 0.6216

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q1476L	TCGA-39-5011	LUSC	TCGA	AMTST	DEG_SPOP_SBC_1	0.0833
p.Q1476L	DO27532	LUSC	ICGC	AMTST	DEG_SPOP_SBC_1	0.0833
p.G1457R	TCGA-AP-A0LM	UCEC	TCGA	AMTST	DEG_SPOP_SBC_1	0.1667
p.G1457R	DO43306	UCEC	ICGC	AMTST	DEG_SPOP_SBC_1	0.1667
p.A1463V	TCGA-AX-A06F	UCEC	TCGA	AMTST	DEG_SPOP_SBC_1	0.5825
p.A1463V	DO41752	UCEC	ICGC	AMTST	DEG_SPOP_SBC_1	0.5825
p.A1456T	ACH-001518	Endometrial/Uterine Cancer	CCLE	AMTST	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1380:1384	AMTST	SPOP	0.6573	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	3003:3007	AMTST	SPOP	0.95	More...
Q9H987	Synaptopodin 2-like protein	DEG_SPOP_SBC_1	575:579	AMTST	SPOP	0.9382	More...
Q9NP60	X-linked interleukin-1 receptor accessory protein-like 2	DEG_SPOP_SBC_1	588:592	AMTST	SPOP	0.5216	More...
Q9UGU0	Transcription factor 20	DEG_SPOP_SBC_1	1463:1467	AMTST	SPOP	0.5189	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons