DegronMD

Uniprot ID: Q9NP60

Source protein: X-linked interleukin-1 receptor accessory protein-like 2

Source gene: IL1RAPL2

Class: DEG_SPOP_SBC_1

Location: 588:592

E3 ligase: SPOP

DEGRON score: 0.5216

ASA_SCORE: 88.74

COIL: 0.9076

CONS_SCORE: 0.2361

DSS_SCORE: 0.3927

HELIX: 0.0516

FCONS_SCORE: 0.9902

RIG_SCORE: 0.7211

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A588T	TCGA-AX-A0J0	UCEC	TCGA	AMTST	DEG_SPOP_SBC_1	0.7139
p.A588T	DO41133	UCEC	ICGC	AMTST	DEG_SPOP_SBC_1	0.7139
p.T592A	ACH-001413	Bladder Cancer	CCLE	AMTST	DEG_SPOP_SBC_1	0.7139
p.A594S	TCGA-A5-A0G1	UCEC	TCGA	AMTST	DEG_SPOP_SBC_1	0.2778
p.A594S	DO42472	UCEC	ICGC	AMTST	DEG_SPOP_SBC_1	0.2778
p.A594T	TCGA-FS-A1ZZ	SKCM	TCGA	AMTST	DEG_SPOP_SBC_1	0.2778
p.A594T	DO37412	SKCM	ICGC	AMTST	DEG_SPOP_SBC_1	0.2778
p.I584R	TCGA-DU-7290	LGG	TCGA	AMTST	DEG_SPOP_SBC_1	0.2222
p.I584R	DO22348	LGG	ICGC	AMTST	DEG_SPOP_SBC_1	0.2222
p.Q582K	SIDM01140	Ovarian Carcinoma	GDSC	AMTST	DEG_SPOP_SBC_1	0.1667
p.Q582K	ACH-001374	Ovarian Cancer	CCLE	AMTST	DEG_SPOP_SBC_1	0.1667
p.Q582K	PA-1	ovary	COSMIC	AMTST	DEG_SPOP_SBC_1	0.1667
p.L581I	TCGA-DK-A2I6	BLCA	TCGA	AMTST	DEG_SPOP_SBC_1	0.1389
p.L581I	DO798	BLCA	ICGC	AMTST	DEG_SPOP_SBC_1	0.1389
p.A601T	TCGA-38-4631	LUAD	TCGA	AMTST	DEG_SPOP_SBC_1	0.0833
p.A601T	DO24970	LUAD	ICGC	AMTST	DEG_SPOP_SBC_1	0.0833

Showing 1 to 16 of 16 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	3003:3007	AMTST	SPOP	0.95	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1380:1384	AMTST	SPOP	0.6573	More...
Q9H987	Synaptopodin 2-like protein	DEG_SPOP_SBC_1	575:579	AMTST	SPOP	0.9382	More...
Q9UGU0	Transcription factor 20	DEG_SPOP_SBC_1	1463:1467	AMTST	SPOP	0.5189	More...
Q9NP60	X-linked interleukin-1 receptor accessory protein-like 2	DEG_SPOP_SBC_1	588:592	AMTST	SPOP	0.5216	More...

Showing 1 to 5 of 5 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons