DegronMD - Q9NP60(IL1RAPL2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T629N	TCGA-24-2260	OV	TCGA	TTLPVPSL	DEG_COP1_1	628:635	Mutation altering degron motif	0.7055
p.T629N	DO29950	OV	ICGC	TTLPVPSL	DEG_COP1_1	628:635	Mutation altering degron motif	0.7055
p.A601T	TCGA-38-4631	LUAD	TCGA	AMTST	DEG_SPOP_SBC_1	588:592	Mutation rewiring degron network	0.0833
p.A601T	DO24970	LUAD	ICGC	AMTST	DEG_SPOP_SBC_1	588:592	Mutation rewiring degron network	0.0833
p.Y621N	TCGA-96-8169	LUSC	TCGA	TTLPVPSL	DEG_COP1_1	628:635	Mutation rewiring degron network	0.1389
p.Y621N	DO26737	LUSC	ICGC	TTLPVPSL	DEG_COP1_1	628:635	Mutation rewiring degron network	0.1389
p.A594S	TCGA-A5-A0G1	UCEC	TCGA	AMTST	DEG_SPOP_SBC_1	588:592	Mutation rewiring degron network	0.2778
p.A594S	DO42472	UCEC	ICGC	AMTST	DEG_SPOP_SBC_1	588:592	Mutation rewiring degron network	0.2778
p.T640A	TCGA-A5-A0GP	UCEC	TCGA	TTLPVPSL	DEG_COP1_1	628:635	Mutation rewiring degron network	0.1944
p.T640A	DO41109	UCEC	ICGC	TTLPVPSL	DEG_COP1_1	628:635	Mutation rewiring degron network	0.1944
p.C642Y	TCGA-A5-A0VP	UCEC	TCGA	TTLPVPSL	DEG_COP1_1	628:635	Mutation rewiring degron network	0.1389
p.C642Y	DO42600	UCEC	ICGC	TTLPVPSL	DEG_COP1_1	628:635	Mutation rewiring degron network	0.1389
p.T628M	TCGA-AR-A2LL	BRCA	TCGA	TTLPVPSL	DEG_COP1_1	628:635	Mutation altering degron motif	0.7423
p.T628M	DO1702	BRCA	ICGC	TTLPVPSL	DEG_COP1_1	628:635	Mutation altering degron motif	0.7423
p.A588T	TCGA-AX-A0J0	UCEC	TCGA	AMTST	DEG_SPOP_SBC_1	588:592	Mutation altering degron motif	0.7139
p.A588T	DO41133	UCEC	ICGC	AMTST	DEG_SPOP_SBC_1	588:592	Mutation altering degron motif	0.7139
p.E624Q	TCGA-BT-A20R	BLCA	TCGA	TTLPVPSL	DEG_COP1_1	628:635	Mutation rewiring degron network	0.2222
p.E624Q	DO622	BLCA	ICGC	TTLPVPSL	DEG_COP1_1	628:635	Mutation rewiring degron network	0.2222
p.L581I	TCGA-DK-A2I6	BLCA	TCGA	AMTST	DEG_SPOP_SBC_1	588:592	Mutation rewiring degron network	0.1389
p.L581I	DO798	BLCA	ICGC	AMTST	DEG_SPOP_SBC_1	588:592	Mutation rewiring degron network	0.1389
p.I584R	TCGA-DU-7290	LGG	TCGA	AMTST	DEG_SPOP_SBC_1	588:592	Mutation rewiring degron network	0.2222
p.I584R	DO22348	LGG	ICGC	AMTST	DEG_SPOP_SBC_1	588:592	Mutation rewiring degron network	0.2222
p.A594T	TCGA-FS-A1ZZ	SKCM	TCGA	AMTST	DEG_SPOP_SBC_1	588:592	Mutation rewiring degron network	0.2778
p.A594T	DO37412	SKCM	ICGC	AMTST	DEG_SPOP_SBC_1	588:592	Mutation rewiring degron network	0.2778
p.R619T	TCGA-P3-A6T5	HNSC	TCGA	TTLPVPSL	DEG_COP1_1	628:635	Mutation rewiring degron network	0.0833
p.R619T	DO49066	HNSC	ICGC	TTLPVPSL	DEG_COP1_1	628:635	Mutation rewiring degron network	0.0833
p.E624K	TCGA-YD-A89C	SKCM	TCGA	TTLPVPSL	DEG_COP1_1	628:635	Mutation rewiring degron network	0.2222
p.E624K	DO219501	SKCM	ICGC	TTLPVPSL	DEG_COP1_1	628:635	Mutation rewiring degron network	0.2222
p.E624G	DO50306	ESAD	ICGC	TTLPVPSL	DEG_COP1_1	628:635	Mutation rewiring degron network	0.2222
p.E624D	SIDM00698	Small Cell Lung Carcinoma	GDSC	TTLPVPSL	DEG_COP1_1	628:635	Mutation rewiring degron network	0.2222
p.E624D	ACH-000506	Lung Cancer	CCLE	TTLPVPSL	DEG_COP1_1	628:635	Mutation rewiring degron network	0.2222
p.E624D	NCI-H146	lung	COSMIC	TTLPVPSL	DEG_COP1_1	628:635	Mutation rewiring degron network	0.2222
p.G620D	SIDM00516	Melanoma	GDSC	TTLPVPSL	DEG_COP1_1	628:635	Mutation rewiring degron network	0.1111
p.G620D	ACH-002166	Skin Cancer	CCLE	TTLPVPSL	DEG_COP1_1	628:635	Mutation rewiring degron network	0.1111
p.G620D	MZ7-mel	skin	COSMIC	TTLPVPSL	DEG_COP1_1	628:635	Mutation rewiring degron network	0.1111
p.Q582K	SIDM01140	Ovarian Carcinoma	GDSC	AMTST	DEG_SPOP_SBC_1	588:592	Mutation rewiring degron network	0.1667
p.Q582K	ACH-001374	Ovarian Cancer	CCLE	AMTST	DEG_SPOP_SBC_1	588:592	Mutation rewiring degron network	0.1667
p.Q582K	PA-1	ovary	COSMIC	AMTST	DEG_SPOP_SBC_1	588:592	Mutation rewiring degron network	0.1667
p.H638R	SIDM00980	Gastric Carcinoma	GDSC	TTLPVPSL	DEG_COP1_1	628:635	Mutation rewiring degron network	0.25
p.H638R	ACH-000948	Gastric Cancer	CCLE	TTLPVPSL	DEG_COP1_1	628:635	Mutation rewiring degron network	0.25
p.H638R	23132-87	stomach	COSMIC	TTLPVPSL	DEG_COP1_1	628:635	Mutation rewiring degron network	0.25
p.T592A	ACH-001413	Bladder Cancer	CCLE	AMTST	DEG_SPOP_SBC_1	588:592	Mutation altering degron motif	0.7139

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IL1RAPL2

UniProt ID: Q9NP60

Entrez ID: 26280

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IL1RAPL2 in