DegronMD

Uniprot ID: Q9NP60

Source protein: X-linked interleukin-1 receptor accessory protein-like 2

Source gene: IL1RAPL2

Class: DEG_COP1_1

Location: 628:635

E3 ligase: COP1

DEGRON score: 0.8354

ASA_SCORE: 62.6625

COIL: 0.7815

CONS_SCORE: 0.2008

DSS_SCORE: 0.2919

HELIX: 0.1069

FCONS_SCORE: 1.119

RIG_SCORE: 0.7059

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T628M	TCGA-AR-A2LL	BRCA	TCGA	TTLPVPSL	DEG_COP1_1	0.7423
p.T628M	DO1702	BRCA	ICGC	TTLPVPSL	DEG_COP1_1	0.7423
p.T629N	TCGA-24-2260	OV	TCGA	TTLPVPSL	DEG_COP1_1	0.7055
p.T629N	DO29950	OV	ICGC	TTLPVPSL	DEG_COP1_1	0.7055
p.H638R	SIDM00980	Gastric Carcinoma	GDSC	TTLPVPSL	DEG_COP1_1	0.25
p.H638R	ACH-000948	Gastric Cancer	CCLE	TTLPVPSL	DEG_COP1_1	0.25
p.H638R	23132-87	stomach	COSMIC	TTLPVPSL	DEG_COP1_1	0.25
p.E624Q	TCGA-BT-A20R	BLCA	TCGA	TTLPVPSL	DEG_COP1_1	0.2222
p.E624Q	DO622	BLCA	ICGC	TTLPVPSL	DEG_COP1_1	0.2222
p.E624K	TCGA-YD-A89C	SKCM	TCGA	TTLPVPSL	DEG_COP1_1	0.2222
p.E624K	DO219501	SKCM	ICGC	TTLPVPSL	DEG_COP1_1	0.2222
p.E624G	DO50306	ESAD	ICGC	TTLPVPSL	DEG_COP1_1	0.2222
p.E624D	SIDM00698	Small Cell Lung Carcinoma	GDSC	TTLPVPSL	DEG_COP1_1	0.2222
p.E624D	ACH-000506	Lung Cancer	CCLE	TTLPVPSL	DEG_COP1_1	0.2222
p.E624D	NCI-H146	lung	COSMIC	TTLPVPSL	DEG_COP1_1	0.2222
p.T640A	TCGA-A5-A0GP	UCEC	TCGA	TTLPVPSL	DEG_COP1_1	0.1944
p.T640A	DO41109	UCEC	ICGC	TTLPVPSL	DEG_COP1_1	0.1944
p.Y621N	TCGA-96-8169	LUSC	TCGA	TTLPVPSL	DEG_COP1_1	0.1389
p.Y621N	DO26737	LUSC	ICGC	TTLPVPSL	DEG_COP1_1	0.1389
p.C642Y	TCGA-A5-A0VP	UCEC	TCGA	TTLPVPSL	DEG_COP1_1	0.1389
p.C642Y	DO42600	UCEC	ICGC	TTLPVPSL	DEG_COP1_1	0.1389
p.G620D	SIDM00516	Melanoma	GDSC	TTLPVPSL	DEG_COP1_1	0.1111
p.G620D	ACH-002166	Skin Cancer	CCLE	TTLPVPSL	DEG_COP1_1	0.1111
p.G620D	MZ7-mel	skin	COSMIC	TTLPVPSL	DEG_COP1_1	0.1111
p.R619T	TCGA-P3-A6T5	HNSC	TCGA	TTLPVPSL	DEG_COP1_1	0.0833

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NP60	X-linked interleukin-1 receptor accessory protein-like 2	DEG_COP1_1	628:635	TTLPVPSL	COP1	0.8354	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons