DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 3003:3007

E3 ligase: SPOP

DEGRON score: 0.95

ASA_SCORE: 87.52

COIL: 0.8286

CONS_SCORE: 0

DSS_SCORE: 0.4728

HELIX: 0.0286

FCONS_SCORE: 0

RIG_SCORE: 0.6712

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S3006L	TCGA-52-7812	LUSC	TCGA	AMTST	DEG_SPOP_SBC_1	0.7667
p.S3006L	DO27067	LUSC	ICGC	AMTST	DEG_SPOP_SBC_1	0.7667
p.S3006L	SIDM01011	B-Cell Non-Hodgkin's Lymphoma	GDSC	AMTST	DEG_SPOP_SBC_1	0.7667
p.T3015I	TCGA-BS-A0V7	UCEC	TCGA	AMTST	DEG_SPOP_SBC_1	0.1111
p.T3015I	DO42392	UCEC	ICGC	AMTST	DEG_SPOP_SBC_1	0.1111
p.S3002L	TCGA-DK-A3IS	BLCA	TCGA	AMTST	DEG_SPOP_SBC_1	0.3056
p.S3002L	DO566	BLCA	ICGC	AMTST	DEG_SPOP_SBC_1	0.3056
p.S3008F	TCGA-EE-A2GO	SKCM	TCGA	AMTST	DEG_SPOP_SBC_1	0.3056
p.S3008F	DO37823	SKCM	ICGC	AMTST	DEG_SPOP_SBC_1	0.3056
p.P2995S	TCGA-YD-A89C	SKCM	TCGA	AMTST	DEG_SPOP_SBC_1	0.1111
p.P2995S	DO219501	SKCM	ICGC	AMTST	DEG_SPOP_SBC_1	0.1111
p.P2995S	SIDM00007	Other Solid Cancers	GDSC	AMTST	DEG_SPOP_SBC_1	0.1111
p.P2995S	ACH-001550	Skin Cancer	CCLE	AMTST	DEG_SPOP_SBC_1	0.1111
p.P2995S	MCC13	skin	COSMIC	AMTST	DEG_SPOP_SBC_1	0.1111
p.P2995A	SIDM00511	Small Cell Lung Carcinoma	GDSC	AMTST	DEG_SPOP_SBC_1	0.1111
p.P2995A	ACH-000257	Lung Cancer	CCLE	AMTST	DEG_SPOP_SBC_1	0.1111
p.P2995A	COR-L279	lung	COSMIC	AMTST	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1380:1384	AMTST	SPOP	0.6573	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	3003:3007	AMTST	SPOP	0.95	More...
Q9H987	Synaptopodin 2-like protein	DEG_SPOP_SBC_1	575:579	AMTST	SPOP	0.9382	More...
Q9NP60	X-linked interleukin-1 receptor accessory protein-like 2	DEG_SPOP_SBC_1	588:592	AMTST	SPOP	0.5216	More...
Q9UGU0	Transcription factor 20	DEG_SPOP_SBC_1	1463:1467	AMTST	SPOP	0.5189	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons