DegronMD - Q9UGU0(TCF20)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T1520M	TCGA-04-1346	OV	TCGA	EKEND	DEG_APCC_KENBOX_2	1513:1517	Mutation blocking phosphorylation signal	0.6944
p.T1520M	DO31340	OV	ICGC	EKEND	DEG_APCC_KENBOX_2	1513:1517	Mutation blocking phosphorylation signal	0.6944
p.A1681V	TCGA-06-1801	GBM	TCGA	PPSST	DEG_SPOP_SBC_1	1673:1677	Mutation rewiring degron network	0.2222
p.A1681V	DO11986	GBM	ICGC	PPSST	DEG_SPOP_SBC_1	1673:1677	Mutation rewiring degron network	0.2222
p.A1681V	SIDM00273	Glioblastoma	GDSC	PPSST	DEG_SPOP_SBC_1	1673:1677	Mutation rewiring degron network	0.2222
p.A1681V	SIDM01588	Endometrial Carcinoma	GDSC	PPSST	DEG_SPOP_SBC_1	1673:1677	Mutation rewiring degron network	0.2222
p.A1681V	ACH-000756	Brain Cancer	CCLE	PPSST	DEG_SPOP_SBC_1	1673:1677	Mutation rewiring degron network	0.2222
p.A1681V	ACH-000993	Endometrial/Uterine Cancer	CCLE	PPSST	DEG_SPOP_SBC_1	1673:1677	Mutation rewiring degron network	0.2222
p.S1522L	TCGA-12-0818	GBM	TCGA	EKEND	DEG_APCC_KENBOX_2	1513:1517	Mutation blocking phosphorylation signal	0.6389
p.S1522L	DO12892	GBM	ICGC	EKEND	DEG_APCC_KENBOX_2	1513:1517	Mutation blocking phosphorylation signal	0.6389
p.T1831S	TCGA-13-0884	OV	TCGA	VPTTS	DEG_SPOP_SBC_1	1828:1832	Mutation altering degron motif	0.6005
p.Q1476L	TCGA-39-5011	LUSC	TCGA	AMTST	DEG_SPOP_SBC_1	1463:1467	Mutation rewiring degron network	0.0833
p.Q1476L	DO27532	LUSC	ICGC	AMTST	DEG_SPOP_SBC_1	1463:1467	Mutation rewiring degron network	0.0833
p.S238C	TCGA-44-3398	LUAD	TCGA	ASSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.3056
p.S238C	DO25030	LUAD	ICGC	ASSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.3056
p.G1835V	TCGA-69-7765	LUAD	TCGA	VPTTS	DEG_SPOP_SBC_1	1828:1832	Mutation rewiring degron network	0.25
p.V1821I	TCGA-85-6798	LUSC	TCGA	VPTTS	DEG_SPOP_SBC_1	1828:1832	Mutation rewiring degron network	0.1389
p.V1821I	DO27295	LUSC	ICGC	VPTTS	DEG_SPOP_SBC_1	1828:1832	Mutation rewiring degron network	0.1389
p.T1520P	TCGA-AA-3815	COAD	TCGA	EKEND	DEG_APCC_KENBOX_2	1513:1517	Mutation blocking phosphorylation signal	0.6944
p.T1520P	DO9924	COAD	ICGC	EKEND	DEG_APCC_KENBOX_2	1513:1517	Mutation blocking phosphorylation signal	0.6944
p.A202V	TCGA-AD-6895	COAD	TCGA	PASSS	DEG_SPOP_SBC_1	201:205	Mutation altering degron motif	0.5825
p.A202V	DO8938	COAD	ICGC	PASSS	DEG_SPOP_SBC_1	201:205	Mutation altering degron motif	0.5825
p.G1457R	TCGA-AP-A0LM	UCEC	TCGA	AMTST	DEG_SPOP_SBC_1	1463:1467	Mutation rewiring degron network	0.1667
p.G1457R	DO43306	UCEC	ICGC	AMTST	DEG_SPOP_SBC_1	1463:1467	Mutation rewiring degron network	0.1667
p.A1463V	TCGA-AX-A06F	UCEC	TCGA	AMTST	DEG_SPOP_SBC_1	1463:1467	Mutation altering degron motif	0.5825
p.A1463V	DO41752	UCEC	ICGC	AMTST	DEG_SPOP_SBC_1	1463:1467	Mutation altering degron motif	0.5825
p.G232D	TCGA-B5-A11E	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.1389
p.G232D	DO41644	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.1389
p.S1522T	TCGA-BC-A10R	LIHC	TCGA	EKEND	DEG_APCC_KENBOX_2	1513:1517	Mutation blocking phosphorylation signal	0.6389
p.S1522T	DO22962	LIHC	ICGC	EKEND	DEG_APCC_KENBOX_2	1513:1517	Mutation blocking phosphorylation signal	0.6389
p.S1827Y	TCGA-BP-5181	KIRC	TCGA	VPTTS	DEG_SPOP_SBC_1	1828:1832	Mutation rewiring degron network	0.3056
p.R213Q	TCGA-FI-A2D5	UCEC	TCGA	PASSS	DEG_SPOP_SBC_1	201:205	Mutation rewiring degron network	0.1111
p.R213Q	DO41331	UCEC	ICGC	PASSS	DEG_SPOP_SBC_1	201:205	Mutation rewiring degron network	0.1111
p.H207Y	TCGA-FR-A726	SKCM	TCGA	PASSS	DEG_SPOP_SBC_1	201:205	Mutation rewiring degron network	0.2778
p.H207Y	DO48665	SKCM	ICGC	PASSS	DEG_SPOP_SBC_1	201:205	Mutation rewiring degron network	0.2778
p.E1837K	TCGA-IR-A3LH	CESC	TCGA	VPTTS	DEG_SPOP_SBC_1	1828:1832	Mutation rewiring degron network	0.1944
p.S1685L	TCGA-KU-A66S	HNSC	TCGA	PPSST	DEG_SPOP_SBC_1	1673:1677	Mutation rewiring degron network	0.1111
p.S1685L	DO44456	HNSC	ICGC	PPSST	DEG_SPOP_SBC_1	1673:1677	Mutation rewiring degron network	0.1111
p.S1685L	SIDM00537	Colorectal Carcinoma	GDSC	PPSST	DEG_SPOP_SBC_1	1673:1677	Mutation rewiring degron network	0.1111
p.S1685L	ACH-000982	Colon/Colorectal Cancer	CCLE	PPSST	DEG_SPOP_SBC_1	1673:1677	Mutation rewiring degron network	0.1111
p.S1685L	ACH-001345	Colon/Colorectal Cancer	CCLE	PPSST	DEG_SPOP_SBC_1	1673:1677	Mutation rewiring degron network	0.1111
p.S1685L	GP5d	large intestine	COSMIC	PPSST	DEG_SPOP_SBC_1	1673:1677	Mutation rewiring degron network	0.1111
p.E1512K	TCGA-LP-A4AV	CESC	TCGA	EKEND	DEG_APCC_KENBOX_2	1513:1517	Mutation rewiring degron network	0.3056
p.E1512K	DO44275	CESC	ICGC	EKEND	DEG_APCC_KENBOX_2	1513:1517	Mutation rewiring degron network	0.3056
p.P1826S	TCGA-UF-A7JO	HNSC	TCGA	VPTTS	DEG_SPOP_SBC_1	1828:1832	Mutation rewiring degron network	0.2778
p.P1826S	DO219088	HNSC	ICGC	VPTTS	DEG_SPOP_SBC_1	1828:1832	Mutation rewiring degron network	0.2778
p.S245F	TCGA-W3-AA1R	SKCM	TCGA	ASSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.2778
p.S245F	DO51275	SKCM	ICGC	ASSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.2778
p.Q246K	DO1380	BRCA	ICGC	ASSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.25
p.A196T	DO10172	COAD	ICGC	PASSS	DEG_SPOP_SBC_1	201:205	Mutation rewiring degron network	0.1944
p.A196T	DO42977	UCEC	ICGC	PASSS	DEG_SPOP_SBC_1	201:205	Mutation rewiring degron network	0.1944
p.R252C	DO233935	GACA	ICGC	ASSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.0833
p.A238V	DO22237	LGG	ICGC	ASSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.3056
p.V1519M	DO50970	LICA	ICGC	EKEND	DEG_APCC_KENBOX_2	1513:1517	Mutation rewiring degron network	0.2778
p.R229T	DO26719	LUSC	ICGC	ASSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.0556
p.S240F	DO220910	MELA	ICGC	ASSSS	DEG_SPOP_SBC_1	239:243	Mutation altering degron motif	0.6871
p.P1505S	DO222527	MELA	ICGC	EKEND	DEG_APCC_KENBOX_2	1513:1517	Mutation rewiring degron network	0.1111
p.P212Q	DO42033	UCEC	ICGC	PASSS	DEG_SPOP_SBC_1	201:205	Mutation rewiring degron network	0.1389
p.A238T	DO43947	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.3056
p.R249Q	DO42552	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	239:243	Mutation blocking phosphorylation signal	0.6111
p.S1675N	SIDM00789	Colorectal Carcinoma	GDSC	PPSST	DEG_SPOP_SBC_1	1673:1677	Mutation altering degron motif	0.7069
p.S1675N	ACH-000997	Colon/Colorectal Cancer	CCLE	PPSST	DEG_SPOP_SBC_1	1673:1677	Mutation altering degron motif	0.7069
p.S1675N	HCT-15	large intestine	COSMIC	PPSST	DEG_SPOP_SBC_1	1673:1677	Mutation altering degron motif	0.7069
p.S215P	SIDM01154	T-Lymphoblastic Leukemia	GDSC	PASSS	DEG_SPOP_SBC_1	201:205	Mutation rewiring degron network	0.0556
p.S215P	ACH-000953	Leukemia	CCLE	PASSS	DEG_SPOP_SBC_1	201:205	Mutation rewiring degron network	0.0556
p.S215P	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	PASSS	DEG_SPOP_SBC_1	201:205	Mutation rewiring degron network	0.0556
p.T1831A	SIDM01076	B-Lymphoblastic Leukemia	GDSC	VPTTS	DEG_SPOP_SBC_1	1828:1832	Mutation altering degron motif	0.7139
p.T1831A	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	VPTTS	DEG_SPOP_SBC_1	1828:1832	Mutation altering degron motif	0.7139
p.T1831A	697	haematopoietic and lymphoid tissue	COSMIC	VPTTS	DEG_SPOP_SBC_1	1828:1832	Mutation altering degron motif	0.7139
p.M211V	SIDM00699	Small Cell Lung Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	201:205	Mutation rewiring degron network	0.1667
p.M211V	ACH-001138	Lung Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	201:205	Mutation rewiring degron network	0.1667
p.M211V	NCI-H2141	lung	COSMIC	PASSS	DEG_SPOP_SBC_1	201:205	Mutation rewiring degron network	0.1667
p.T1677A	SIDM00534	Colorectal Carcinoma	GDSC	PPSST	DEG_SPOP_SBC_1	1673:1677	Mutation altering degron motif	0.7139
p.T1677A	ACH-000986	Colon/Colorectal Cancer	CCLE	PPSST	DEG_SPOP_SBC_1	1673:1677	Mutation altering degron motif	0.7139
p.T1677A	HT-115	large intestine	COSMIC	PPSST	DEG_SPOP_SBC_1	1673:1677	Mutation altering degron motif	0.7139
p.S246C	SIDM00603	Head and Neck Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.25
p.G232R	SIDM01018	Hodgkin's Lymphoma	GDSC	ASSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.1389
p.G232R	ACH-000815	Lymphoma	CCLE	ASSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.1389
p.G232R	KM-H2	haematopoietic and lymphoid tissue	COSMIC	ASSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.1389
p.A1456T	ACH-001518	Endometrial/Uterine Cancer	CCLE	AMTST	DEG_SPOP_SBC_1	1463:1467	Mutation rewiring degron network	0.1389
p.E1818G	ACH-001573	Leukemia	CCLE	VPTTS	DEG_SPOP_SBC_1	1828:1832	Mutation rewiring degron network	0.0556
p.G199C	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PASSS	DEG_SPOP_SBC_1	201:205	Mutation rewiring degron network	0.2778
p.P212L	SW48	large intestine	COSMIC	PASSS	DEG_SPOP_SBC_1	201:205	Mutation rewiring degron network	0.1389
p.P212L	SNU-175	large intestine	COSMIC	PASSS	DEG_SPOP_SBC_1	201:205	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TCF20

UniProt ID: Q9UGU0

Entrez ID: 6942

Protein name: Transcription factor 20 (TCF-20) (Nuclear factor SPBP) (Protein AR1) (Stromelysin-1 PDGF-responsive element-binding protein) (SPRE-binding protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TCF20 in