DegronMD - Q9UGU0(TCF20)

FUNCTION: Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator. {ECO:0000269|PubMed:10995766}.

GO - Biological processes (BP): positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]

GO - Molecular function (MF): DNA binding [GO:0003677]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]

GO - Cellular component (CC): nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T1831A	SIDM01076	B-Lymphoblastic Leukemia	GDSC	VPTTS	DEG_SPOP_SBC_1	1828:1832	Mutation altering degron motif	0.7139
p.T1831A	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	VPTTS	DEG_SPOP_SBC_1	1828:1832	Mutation altering degron motif	0.7139
p.T1831A	697	haematopoietic and lymphoid tissue	COSMIC	VPTTS	DEG_SPOP_SBC_1	1828:1832	Mutation altering degron motif	0.7139
p.T1677A	SIDM00534	Colorectal Carcinoma	GDSC	PPSST	DEG_SPOP_SBC_1	1673:1677	Mutation altering degron motif	0.7139
p.T1677A	ACH-000986	Colon/Colorectal Cancer	CCLE	PPSST	DEG_SPOP_SBC_1	1673:1677	Mutation altering degron motif	0.7139
p.T1677A	HT-115	large intestine	COSMIC	PPSST	DEG_SPOP_SBC_1	1673:1677	Mutation altering degron motif	0.7139
p.S1675N	SIDM00789	Colorectal Carcinoma	GDSC	PPSST	DEG_SPOP_SBC_1	1673:1677	Mutation altering degron motif	0.7069
p.S1675N	ACH-000997	Colon/Colorectal Cancer	CCLE	PPSST	DEG_SPOP_SBC_1	1673:1677	Mutation altering degron motif	0.7069
p.S1675N	HCT-15	large intestine	COSMIC	PPSST	DEG_SPOP_SBC_1	1673:1677	Mutation altering degron motif	0.7069
p.T1520M	TCGA-04-1346	OV	TCGA	EKEND	DEG_APCC_KENBOX_2	1513:1517	Mutation blocking phosphorylation signal	0.6944
p.T1520M	DO31340	OV	ICGC	EKEND	DEG_APCC_KENBOX_2	1513:1517	Mutation blocking phosphorylation signal	0.6944
p.T1520P	TCGA-AA-3815	COAD	TCGA	EKEND	DEG_APCC_KENBOX_2	1513:1517	Mutation blocking phosphorylation signal	0.6944
p.T1520P	DO9924	COAD	ICGC	EKEND	DEG_APCC_KENBOX_2	1513:1517	Mutation blocking phosphorylation signal	0.6944
p.S240F	DO220910	MELA	ICGC	ASSSS	DEG_SPOP_SBC_1	239:243	Mutation altering degron motif	0.6871
p.S1522L	TCGA-12-0818	GBM	TCGA	EKEND	DEG_APCC_KENBOX_2	1513:1517	Mutation blocking phosphorylation signal	0.6389
p.S1522L	DO12892	GBM	ICGC	EKEND	DEG_APCC_KENBOX_2	1513:1517	Mutation blocking phosphorylation signal	0.6389
p.S1522T	TCGA-BC-A10R	LIHC	TCGA	EKEND	DEG_APCC_KENBOX_2	1513:1517	Mutation blocking phosphorylation signal	0.6389
p.S1522T	DO22962	LIHC	ICGC	EKEND	DEG_APCC_KENBOX_2	1513:1517	Mutation blocking phosphorylation signal	0.6389
p.R249Q	DO42552	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	239:243	Mutation blocking phosphorylation signal	0.6111
p.T1831S	TCGA-13-0884	OV	TCGA	VPTTS	DEG_SPOP_SBC_1	1828:1832	Mutation altering degron motif	0.6005

Showing 1 to 20 of 84 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

TCF20

UniProt ID: Q9UGU0

Entrez ID: 6942

Protein name: Transcription factor 20 (TCF-20) (Nuclear factor SPBP) (Protein AR1) (Stromelysin-1 PDGF-responsive element-binding protein) (SPRE-binding protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TCF20 in