DegronMD

Uniprot ID: Q9UGU0

Source protein: Transcription factor 20

Source gene: TCF20

Class: DEG_APCC_KENBOX_2

Location: 1513:1517

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7113

ASA_SCORE: 112.48

COIL: 0.6756

CONS_SCORE: 0.3031

DSS_SCORE: 0.691

HELIX: 0.323

FCONS_SCORE: 0.8176

RIG_SCORE: 0.6868

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1520M	TCGA-04-1346	OV	TCGA	EKEND	DEG_APCC_KENBOX_2	0.6944
p.T1520M	DO31340	OV	ICGC	EKEND	DEG_APCC_KENBOX_2	0.6944
p.S1522L	TCGA-12-0818	GBM	TCGA	EKEND	DEG_APCC_KENBOX_2	0.6389
p.S1522L	DO12892	GBM	ICGC	EKEND	DEG_APCC_KENBOX_2	0.6389
p.T1520P	TCGA-AA-3815	COAD	TCGA	EKEND	DEG_APCC_KENBOX_2	0.6944
p.T1520P	DO9924	COAD	ICGC	EKEND	DEG_APCC_KENBOX_2	0.6944
p.S1522T	TCGA-BC-A10R	LIHC	TCGA	EKEND	DEG_APCC_KENBOX_2	0.6389
p.S1522T	DO22962	LIHC	ICGC	EKEND	DEG_APCC_KENBOX_2	0.6389
p.E1512K	TCGA-LP-A4AV	CESC	TCGA	EKEND	DEG_APCC_KENBOX_2	0.3056
p.E1512K	DO44275	CESC	ICGC	EKEND	DEG_APCC_KENBOX_2	0.3056
p.V1519M	DO50970	LICA	ICGC	EKEND	DEG_APCC_KENBOX_2	0.2778
p.P1505S	DO222527	MELA	ICGC	EKEND	DEG_APCC_KENBOX_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00763	Acetyl-CoA carboxylase 2	DEG_APCC_KENBOX_2	889:893	EKEND	APC,CDC20,FZR1	0.9263	More...
O60293	Zinc finger C3H1 domain-containing protein	DEG_APCC_KENBOX_2	758:762	EKEND	APC,CDC20,FZR1	0.8227	More...
Q8IUC4	Rhophilin-2	DEG_APCC_KENBOX_2	14:18	EKEND	APC,CDC20,FZR1	0.8735	More...
Q9UGU0	Transcription factor 20	DEG_APCC_KENBOX_2	1513:1517	EKEND	APC,CDC20,FZR1	0.7113	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons