DegronMD

Uniprot ID: O60293

Source protein: Zinc finger C3H1 domain-containing protein

Source gene: ZFC3H1

Class: DEG_APCC_KENBOX_2

Location: 758:762

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8227

ASA_SCORE: 131.44

COIL: 0.9424

CONS_SCORE: 0.4274

DSS_SCORE: 0.7119

HELIX: 0.0406

FCONS_SCORE: 0.9298

RIG_SCORE: 0.5925

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R765Q	TCGA-AA-3519	COAD	TCGA	EKEND	DEG_APCC_KENBOX_2	0.25
p.R765Q	DO7914	COAD	ICGC	EKEND	DEG_APCC_KENBOX_2	0.25
p.E768D	TCGA-AP-A051	UCEC	TCGA	EKEND	DEG_APCC_KENBOX_2	0.1667
p.E768D	DO42673	UCEC	ICGC	EKEND	DEG_APCC_KENBOX_2	0.1667
p.P771S	TCGA-EY-A215	UCEC	TCGA	EKEND	DEG_APCC_KENBOX_2	0.0833
p.P771S	DO42665	UCEC	ICGC	EKEND	DEG_APCC_KENBOX_2	0.0833
p.K752R	DO222772	BTCA	ICGC	EKEND	DEG_APCC_KENBOX_2	0.2778
p.A748D	DO228971	LICA	ICGC	EKEND	DEG_APCC_KENBOX_2	0.0556
p.P751T	DO229034	LICA	ICGC	EKEND	DEG_APCC_KENBOX_2	0.1389
p.E758Q	SIDM01257	Hepatocellular Carcinoma	GDSC	EKEND	DEG_APCC_KENBOX_2	0.5633
p.E758Q	SIDM00062	Hepatocellular Carcinoma	GDSC	EKEND	DEG_APCC_KENBOX_2	0.5633
p.E758Q	ACH-000671	Liver Cancer	CCLE	EKEND	DEG_APCC_KENBOX_2	0.5633
p.K759N	SIDM00528	Breast Carcinoma	GDSC	EKEND	DEG_APCC_KENBOX_2	0.6918
p.K759N	ACH-000934	Breast Cancer	CCLE	EKEND	DEG_APCC_KENBOX_2	0.6918
p.K759N	MDA-MB-361	breast	COSMIC	EKEND	DEG_APCC_KENBOX_2	0.6918
p.A769D	ACH-000755	Breast Cancer	CCLE	EKEND	DEG_APCC_KENBOX_2	0.1389
p.A769D	HCC2218	breast	COSMIC	EKEND	DEG_APCC_KENBOX_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00763	Acetyl-CoA carboxylase 2	DEG_APCC_KENBOX_2	889:893	EKEND	APC,CDC20,FZR1	0.9263	More...
O60293	Zinc finger C3H1 domain-containing protein	DEG_APCC_KENBOX_2	758:762	EKEND	APC,CDC20,FZR1	0.8227	More...
Q8IUC4	Rhophilin-2	DEG_APCC_KENBOX_2	14:18	EKEND	APC,CDC20,FZR1	0.8735	More...
Q9UGU0	Transcription factor 20	DEG_APCC_KENBOX_2	1513:1517	EKEND	APC,CDC20,FZR1	0.7113	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons