DegronMD

Uniprot ID: Q8IUC4

Source protein: Rhophilin-2

Source gene: RHPN2

Class: DEG_APCC_KENBOX_2

Location: 14:18

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8735

ASA_SCORE: 111.96

COIL: 0.7548

CONS_SCORE: 0.422

DSS_SCORE: 0.5451

HELIX: 0.1514

FCONS_SCORE: 0.8691

RIG_SCORE: 0.7027

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N26T	TCGA-AJ-A3EK	UCEC	TCGA	EKEND	DEG_APCC_KENBOX_2	0.1111
p.N26T	DO41584	UCEC	ICGC	EKEND	DEG_APCC_KENBOX_2	0.1111
p.L5M	DO228978	LICA	ICGC	EKEND	DEG_APCC_KENBOX_2	0.1944
p.P12T	DO229037	LICA	ICGC	EKEND	DEG_APCC_KENBOX_2	0.2778
p.F21I	DO229199	THCA	ICGC	EKEND	DEG_APCC_KENBOX_2	0.25
p.C25F	SIDM00035	Thyroid Gland Carcinoma	GDSC	EKEND	DEG_APCC_KENBOX_2	0.1389
p.C25F	ACH-000037	Sarcoma	CCLE	EKEND	DEG_APCC_KENBOX_2	0.1389
p.C25F	S-117	soft_tissue	COSMIC	EKEND	DEG_APCC_KENBOX_2	0.1389
p.G19D	ACH-001518	Endometrial/Uterine Cancer	CCLE	EKEND	DEG_APCC_KENBOX_2	0.3056
p.A4V	ACH-001735	Leukemia	CCLE	EKEND	DEG_APCC_KENBOX_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00763	Acetyl-CoA carboxylase 2	DEG_APCC_KENBOX_2	889:893	EKEND	APC,CDC20,FZR1	0.9263	More...
O60293	Zinc finger C3H1 domain-containing protein	DEG_APCC_KENBOX_2	758:762	EKEND	APC,CDC20,FZR1	0.8227	More...
Q8IUC4	Rhophilin-2	DEG_APCC_KENBOX_2	14:18	EKEND	APC,CDC20,FZR1	0.8735	More...
Q9UGU0	Transcription factor 20	DEG_APCC_KENBOX_2	1513:1517	EKEND	APC,CDC20,FZR1	0.7113	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons