DegronMD - O60293(ZFC3H1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R765Q	TCGA-AA-3519	COAD	TCGA	EKEND	DEG_APCC_KENBOX_2	758:762	Mutation rewiring degron network	0.25
p.R765Q	DO7914	COAD	ICGC	EKEND	DEG_APCC_KENBOX_2	758:762	Mutation rewiring degron network	0.25
p.E768D	TCGA-AP-A051	UCEC	TCGA	EKEND	DEG_APCC_KENBOX_2	758:762	Mutation rewiring degron network	0.1667
p.E768D	DO42673	UCEC	ICGC	EKEND	DEG_APCC_KENBOX_2	758:762	Mutation rewiring degron network	0.1667
p.S419L	TCGA-AP-A056	UCEC	TCGA	VKTST	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.2222
p.S419L	DO43971	UCEC	ICGC	VKTST	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.2222
p.R667I	TCGA-AP-A1E0	UCEC	TCGA	PRSNLSIVS	DEG_APCC_DBOX_1	666:674	Mutation altering degron motif	0.8102
p.R667I	DO43154	UCEC	ICGC	PRSNLSIVS	DEG_APCC_DBOX_1	666:674	Mutation altering degron motif	0.8102
p.P771S	TCGA-EY-A215	UCEC	TCGA	EKEND	DEG_APCC_KENBOX_2	758:762	Mutation rewiring degron network	0.0833
p.P771S	DO42665	UCEC	ICGC	EKEND	DEG_APCC_KENBOX_2	758:762	Mutation rewiring degron network	0.0833
p.Q409H	TCGA-P3-A6T5	HNSC	TCGA	VKTST	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.2778
p.Q409H	DO49066	HNSC	ICGC	VKTST	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.2778
p.K752R	DO222772	BTCA	ICGC	EKEND	DEG_APCC_KENBOX_2	758:762	Mutation substituting flanking lysine	0.2778
p.S424N	DO230343	COCA	ICGC	VKTST	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.0833
p.Q409K	DO228976	LICA	ICGC	VKTST	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.2778
p.A748D	DO228971	LICA	ICGC	EKEND	DEG_APCC_KENBOX_2	758:762	Mutation rewiring degron network	0.0556
p.P751T	DO229034	LICA	ICGC	EKEND	DEG_APCC_KENBOX_2	758:762	Mutation rewiring degron network	0.1389
p.T404K	DO229036	LICA	ICGC	VKTST	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.1389
p.P664H	DO222743	MELA	ICGC	PRSNLSIVS	DEG_APCC_DBOX_1	666:674	Mutation rewiring degron network	0.2778
p.T677P	DO232224	PBCA	ICGC	PRSNLSIVS	DEG_APCC_DBOX_1	666:674	Mutation rewiring degron network	0.25
p.V423G	SIDM01290	Esophageal Carcinoma	GDSC	VKTST	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.1111
p.I672V	SIDM00194	Colorectal Carcinoma	GDSC	PRSNLSIVS	DEG_APCC_DBOX_1	666:674	Mutation altering degron motif	0.5965
p.I672V	SNU-61	large intestine	COSMIC	PRSNLSIVS	DEG_APCC_DBOX_1	666:674	Mutation altering degron motif	0.5965
p.Q408H	SIDM00238	Ovarian Carcinoma	GDSC	VKTST	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.25
p.Q408H	ACH-000947	Ovarian Cancer	CCLE	VKTST	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.25
p.Q408H	OVK-18	ovary	COSMIC	VKTST	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.25
p.T406I	SIDM00282	Colorectal Carcinoma	GDSC	VKTST	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.1944
p.T406I	ACH-000998	Colon/Colorectal Cancer	CCLE	VKTST	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.1944
p.T406I	CW-2	large intestine	COSMIC	VKTST	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.1944
p.E758Q	SIDM01257	Hepatocellular Carcinoma	GDSC	EKEND	DEG_APCC_KENBOX_2	758:762	Mutation altering degron motif	0.5633
p.E758Q	SIDM00062	Hepatocellular Carcinoma	GDSC	EKEND	DEG_APCC_KENBOX_2	758:762	Mutation altering degron motif	0.5633
p.E758Q	ACH-000671	Liver Cancer	CCLE	EKEND	DEG_APCC_KENBOX_2	758:762	Mutation altering degron motif	0.5633
p.K759N	SIDM00528	Breast Carcinoma	GDSC	EKEND	DEG_APCC_KENBOX_2	758:762	Mutation altering degron motif	0.6918
p.K759N	ACH-000934	Breast Cancer	CCLE	EKEND	DEG_APCC_KENBOX_2	758:762	Mutation altering degron motif	0.6918
p.K759N	MDA-MB-361	breast	COSMIC	EKEND	DEG_APCC_KENBOX_2	758:762	Mutation altering degron motif	0.6918
p.K422E	SIDM01612	Endometrial Carcinoma	GDSC	VKTST	DEG_SPOP_SBC_1	411:415	Mutation substituting flanking lysine	0.25
p.A769D	ACH-000755	Breast Cancer	CCLE	EKEND	DEG_APCC_KENBOX_2	758:762	Mutation rewiring degron network	0.1389
p.A769D	HCC2218	breast	COSMIC	EKEND	DEG_APCC_KENBOX_2	758:762	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZFC3H1

UniProt ID: O60293

Entrez ID: 196441

Protein name: Zinc finger C3H1 domain-containing protein (Coiled-coil domain-containing protein 131) (Proline/serine-rich coiled-coil protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZFC3H1 in