DegronMD

Uniprot ID: O60293

Source protein: Zinc finger C3H1 domain-containing protein

Source gene: ZFC3H1

Class: DEG_SPOP_SBC_1

Location: 411:415

E3 ligase: SPOP

DEGRON score: 0.9877

ASA_SCORE: 107

COIL: 0.9268

CONS_SCORE: 0.4687

DSS_SCORE: 0.5551

HELIX: 0.0486

FCONS_SCORE: 1.0173

RIG_SCORE: 0.6852

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S419L	TCGA-AP-A056	UCEC	TCGA	VKTST	DEG_SPOP_SBC_1	0.2222
p.S419L	DO43971	UCEC	ICGC	VKTST	DEG_SPOP_SBC_1	0.2222
p.Q409H	TCGA-P3-A6T5	HNSC	TCGA	VKTST	DEG_SPOP_SBC_1	0.2778
p.Q409H	DO49066	HNSC	ICGC	VKTST	DEG_SPOP_SBC_1	0.2778
p.S424N	DO230343	COCA	ICGC	VKTST	DEG_SPOP_SBC_1	0.0833
p.Q409K	DO228976	LICA	ICGC	VKTST	DEG_SPOP_SBC_1	0.2778
p.T404K	DO229036	LICA	ICGC	VKTST	DEG_SPOP_SBC_1	0.1389
p.V423G	SIDM01290	Esophageal Carcinoma	GDSC	VKTST	DEG_SPOP_SBC_1	0.1111
p.Q408H	SIDM00238	Ovarian Carcinoma	GDSC	VKTST	DEG_SPOP_SBC_1	0.25
p.Q408H	ACH-000947	Ovarian Cancer	CCLE	VKTST	DEG_SPOP_SBC_1	0.25
p.Q408H	OVK-18	ovary	COSMIC	VKTST	DEG_SPOP_SBC_1	0.25
p.T406I	SIDM00282	Colorectal Carcinoma	GDSC	VKTST	DEG_SPOP_SBC_1	0.1944
p.T406I	ACH-000998	Colon/Colorectal Cancer	CCLE	VKTST	DEG_SPOP_SBC_1	0.1944
p.T406I	CW-2	large_intestine	COSMIC	VKTST	DEG_SPOP_SBC_1	0.1944
p.K422E	SIDM01612	Endometrial Carcinoma	GDSC	VKTST	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A4UGR9	Xin actin-binding repeat-containing protein 2	DEG_SPOP_SBC_1	1274:1278	VKTST	SPOP	0.9434	More...
O60293	Zinc finger C3H1 domain-containing protein	DEG_SPOP_SBC_1	411:415	VKTST	SPOP	0.9877	More...
Q8WWI1	LIM domain only protein 7	DEG_SPOP_SBC_1	1574:1578	VKTST	SPOP	0.975	More...
Q9H799	Ciliogenesis and planar polarity effector 1	DEG_SPOP_SBC_1	1777:1781	VKTST	SPOP	0.6764	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons