DegronMD

Uniprot ID: Q9H799

Source protein: Ciliogenesis and planar polarity effector 1

Source gene: CPLANE1

Class: DEG_SPOP_SBC_1

Location: 1777:1781

E3 ligase: SPOP

DEGRON score: 0.6764

ASA_SCORE: 76.02

COIL: 0.7914

CONS_SCORE: 0.3543

DSS_SCORE: 0.0689

HELIX: 0.0694

FCONS_SCORE: 0.7655

RIG_SCORE: 0.8466

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K1778N	SIDM01006	Plasma Cell Myeloma	GDSC	VKTST	DEG_SPOP_SBC_1	0.5806
p.K1778N	KARPAS-620	haematopoietic_and_lymphoid_tissue	COSMIC	VKTST	DEG_SPOP_SBC_1	0.5806
p.V1777I	SIDM01021	Glioblastoma	GDSC	VKTST	DEG_SPOP_SBC_1	0.7076
p.V1777I	SIDM00539	Esophageal Carcinoma	GDSC	VKTST	DEG_SPOP_SBC_1	0.7076
p.V1777I	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	VKTST	DEG_SPOP_SBC_1	0.7076

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A4UGR9	Xin actin-binding repeat-containing protein 2	DEG_SPOP_SBC_1	1274:1278	VKTST	SPOP	0.9434	More...
O60293	Zinc finger C3H1 domain-containing protein	DEG_SPOP_SBC_1	411:415	VKTST	SPOP	0.9877	More...
Q8WWI1	LIM domain only protein 7	DEG_SPOP_SBC_1	1574:1578	VKTST	SPOP	0.975	More...
Q9H799	Ciliogenesis and planar polarity effector 1	DEG_SPOP_SBC_1	1777:1781	VKTST	SPOP	0.6764	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons