DegronMD

Uniprot ID: Q8WWI1

Source protein: LIM domain only protein 7

Source gene: LMO7

Class: DEG_SPOP_SBC_1

Location: 1574:1578

E3 ligase: SPOP

DEGRON score: 0.975

ASA_SCORE: 98.62

COIL: 0.93

CONS_SCORE: 0.2557

DSS_SCORE: 0.6809

HELIX: 0.0216

FCONS_SCORE: 0.8944

RIG_SCORE: 0.5993

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H1587R	SIDM00183	Small Cell Lung Carcinoma	GDSC	VKTST	DEG_SPOP_SBC_1	0.0833
p.H1587R	SIDM01648	Non-Cancerous	GDSC	VKTST	DEG_SPOP_SBC_1	0.0833
p.L1580P	SIDM01088	Endometrial Carcinoma	GDSC	VKTST	DEG_SPOP_SBC_1	0.2778
p.L1580P	RL95-2	endometrium	COSMIC	VKTST	DEG_SPOP_SBC_1	0.2778
p.A1574T	SIDM00214	Colorectal Carcinoma	GDSC	VKTST	DEG_SPOP_SBC_1	0.7139
p.A1574T	SNU-407	large_intestine	COSMIC	VKTST	DEG_SPOP_SBC_1	0.7139
p.H1587Y	SIDM00217	Colorectal Carcinoma	GDSC	VKTST	DEG_SPOP_SBC_1	0.0833
p.H1587Y	SNU-1040	large_intestine	COSMIC	VKTST	DEG_SPOP_SBC_1	0.0833
p.I1568F	NCI-H650	lung	COSMIC	VKTST	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A4UGR9	Xin actin-binding repeat-containing protein 2	DEG_SPOP_SBC_1	1274:1278	VKTST	SPOP	0.9434	More...
O60293	Zinc finger C3H1 domain-containing protein	DEG_SPOP_SBC_1	411:415	VKTST	SPOP	0.9877	More...
Q8WWI1	LIM domain only protein 7	DEG_SPOP_SBC_1	1574:1578	VKTST	SPOP	0.975	More...
Q9H799	Ciliogenesis and planar polarity effector 1	DEG_SPOP_SBC_1	1777:1781	VKTST	SPOP	0.6764	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons