DegronMD - Q9H799(CPLANE1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I1996F	SIDM01293	Colorectal Carcinoma	GDSC	VDTSS	DEG_SPOP_SBC_1	1985:1989	Mutation rewiring degron network	0.1389
p.V1448A	SIDM00373	Endometrial Carcinoma	GDSC	SRSTLTELG	DEG_APCC_DBOX_1	1458:1466	Mutation rewiring degron network	0.0556
p.V1448A	SNG-M	endometrium	COSMIC	SRSTLTELG	DEG_APCC_DBOX_1	1458:1466	Mutation rewiring degron network	0.0556
p.K1778N	SIDM01006	Plasma Cell Myeloma	GDSC	VKTST	DEG_SPOP_SBC_1	1777:1781	Mutation altering degron motif	0.5806
p.K1778N	KARPAS-620	haematopoietic and lymphoid tissue	COSMIC	VKTST	DEG_SPOP_SBC_1	1777:1781	Mutation altering degron motif	0.5806
p.V1777I	SIDM01021	Glioblastoma	GDSC	VKTST	DEG_SPOP_SBC_1	1777:1781	Mutation altering degron motif	0.7076
p.V1777I	SIDM00539	Esophageal Carcinoma	GDSC	VKTST	DEG_SPOP_SBC_1	1777:1781	Mutation altering degron motif	0.7076
p.V1777I	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	VKTST	DEG_SPOP_SBC_1	1777:1781	Mutation altering degron motif	0.7076
p.R1459T	SIDM01090	Colorectal Carcinoma	GDSC	SRSTLTELG	DEG_APCC_DBOX_1	1458:1466	Mutation altering degron motif	0.7876
p.N2015S	SIDM01005	Acute Myeloid Leukemia	GDSC	PAPTPQKT	DEG_SCF_FBW7_1	2021:2028	Mutation rewiring degron network	0.1667
p.N2015S	KASUMI-1	haematopoietic and lymphoid tissue	COSMIC	PAPTPQKT	DEG_SCF_FBW7_1	2021:2028	Mutation rewiring degron network	0.1667
p.S1452F	SIDM00790	Non-Cancerous	GDSC	SRSTLTELG	DEG_APCC_DBOX_1	1458:1466	Mutation rewiring degron network	0.1667
p.S1452F	SIDM00775	Non-Small Cell Lung Carcinoma	GDSC	SRSTLTELG	DEG_APCC_DBOX_1	1458:1466	Mutation rewiring degron network	0.1667
p.T1463I	SIDM00900	Non-Cancerous	GDSC	SRSTLTELG	DEG_APCC_DBOX_1	1458:1466	Mutation altering degron motif	0.5966
p.T1463I	ARH-77	haematopoietic and lymphoid tissue	COSMIC	SRSTLTELG	DEG_APCC_DBOX_1	1458:1466	Mutation altering degron motif	0.5966
p.A1994T	SIDM00534	Colorectal Carcinoma	GDSC	VDTSS	DEG_SPOP_SBC_1	1985:1989	Mutation rewiring degron network	0.1944
p.A1994T	HT-115	large intestine	COSMIC	VDTSS	DEG_SPOP_SBC_1	1985:1989	Mutation rewiring degron network	0.1944
p.Y1451F	SIDM01228	Melanoma	GDSC	SRSTLTELG	DEG_APCC_DBOX_1	1458:1466	Mutation blocking phosphorylation signal	0.5833
p.Y1451F	CHL-1	skin	COSMIC	SRSTLTELG	DEG_APCC_DBOX_1	1458:1466	Mutation blocking phosphorylation signal	0.5833
p.E1844D	SIDM01377	Ovarian Carcinoma	GDSC	VATPGGT	DEG_SCF_FBW7_1	1836:1842	Mutation rewiring degron network	0.2778
p.C1852G	SIDM01591	Breast Carcinoma	GDSC	VATPGGT	DEG_SCF_FBW7_1	1836:1842	Mutation rewiring degron network	0.0556

Kaplan plot for CPLANE1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CPLANE1

UniProt ID: Q9H799

Entrez ID: 65250

Protein name: Ciliogenesis and planar polarity effector 1 (Protein JBTS17)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CPLANE1 in