DegronMD

Uniprot ID: Q9H799

Source protein: Ciliogenesis and planar polarity effector 1

Source gene: CPLANE1

Class: DEG_SPOP_SBC_1

Location: 1985:1989

E3 ligase: SPOP

DEGRON score: 0.9585

ASA_SCORE: 84.82

COIL: 0.8736

CONS_SCORE: 0.2954

DSS_SCORE: 0.5976

HELIX: 0.1112

FCONS_SCORE: 0.8513

RIG_SCORE: 0.7043

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I1996F	SIDM01293	Colorectal Carcinoma	GDSC	VDTSS	DEG_SPOP_SBC_1	0.1389
p.A1994T	SIDM00534	Colorectal Carcinoma	GDSC	VDTSS	DEG_SPOP_SBC_1	0.1944
p.A1994T	HT-115	large_intestine	COSMIC	VDTSS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95359	Transforming acidic coiled-coil-containing protein 2	DEG_SPOP_SBC_1	1392:1396	VDTSS	SPOP	0.9909	More...
P06454	Prothymosin alpha [Cleaved into: Prothymosin alpha, N-terminally processed; Thymosin alpha-1]	DEG_SPOP_SBC_1	6:10	VDTSS	SPOP	0.9544	More...
P12270	Nucleoprotein TPR	DEG_SPOP_SBC_1	2313:2317	VDTSS	SPOP	0.5257	More...
P16435	NADPH--cytochrome P450 reductase	DEG_SPOP_SBC_1	6:10	VDTSS	SPOP	0.7465	More...
Q96T58	Msx2-interacting protein	DEG_SPOP_SBC_1	2527:2531	VDTSS	SPOP	0.9726	More...
Q9C0D2	Centrosomal protein of 295 kDa	DEG_SPOP_SBC_1	1392:1396	VDTSS	SPOP	0.9888	More...
Q9H799	Ciliogenesis and planar polarity effector 1	DEG_SPOP_SBC_1	1985:1989	VDTSS	SPOP	0.9585	More...
Q9ULD8	Potassium voltage-gated channel subfamily H member 3	DEG_SPOP_SBC_1	713:717	VDTSS	SPOP	0.8379	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons