DegronMD

Uniprot ID: P06454

Source protein: Prothymosin alpha [Cleaved into: Prothymosin alpha, N-terminally processed; Thymosin alpha-1]

Source gene: PTMA

Class: DEG_SPOP_SBC_1

Location: 6:10

E3 ligase: SPOP

DEGRON score: 0.9544

ASA_SCORE: 65.56

COIL: 0.7784

CONS_SCORE: 0.8835

DSS_SCORE: 0.7033

HELIX: 0.0952

FCONS_SCORE: 0.9695

RIG_SCORE: 0.7083

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S9G	TCGA-D1-A1NZ	UCEC	TCGA	VDTSS	DEG_SPOP_SBC_1	0.8104
p.V16I	DO8938	COAD	ICGC	VDTSS	DEG_SPOP_SBC_1	0.1667
p.W16L	DO228974	LICA	ICGC	VDTSS	DEG_SPOP_SBC_1	0.1667
p.V12L	DO229015	LICA	ICGC	VDTSS	DEG_SPOP_SBC_1	0.2778
p.R14L	DO229045	LICA	ICGC	VDTSS	DEG_SPOP_SBC_1	0.2222
p.G5W	DO229009	LICA	ICGC	VDTSS	DEG_SPOP_SBC_1	0.75
p.A11T	DO42608	UCEC	ICGC	VDTSS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95359	Transforming acidic coiled-coil-containing protein 2	DEG_SPOP_SBC_1	1392:1396	VDTSS	SPOP	0.9909	More...
P06454	Prothymosin alpha [Cleaved into: Prothymosin alpha, N-terminally processed; Thymosin alpha-1]	DEG_SPOP_SBC_1	6:10	VDTSS	SPOP	0.9544	More...
P12270	Nucleoprotein TPR	DEG_SPOP_SBC_1	2313:2317	VDTSS	SPOP	0.5257	More...
P16435	NADPH--cytochrome P450 reductase	DEG_SPOP_SBC_1	6:10	VDTSS	SPOP	0.7465	More...
Q96T58	Msx2-interacting protein	DEG_SPOP_SBC_1	2527:2531	VDTSS	SPOP	0.9726	More...
Q9C0D2	Centrosomal protein of 295 kDa	DEG_SPOP_SBC_1	1392:1396	VDTSS	SPOP	0.9888	More...
Q9H799	Ciliogenesis and planar polarity effector 1	DEG_SPOP_SBC_1	1985:1989	VDTSS	SPOP	0.9585	More...
Q9ULD8	Potassium voltage-gated channel subfamily H member 3	DEG_SPOP_SBC_1	713:717	VDTSS	SPOP	0.8379	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons